Memory--a Century of Consolidation

American Association for the Advancement of Science (AAAS) - Tập 287 Số 5451 - Trang 248-251 - 2000
James L. McGaugh1
1The author is at the Center for the Neurobiology of Learning and Memory and the Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA 92697, USA.

Tóm tắt

The memory consolidation hypothesis proposed 100 years ago by Müller and Pilzecker continues to guide memory research. The hypothesis that new memories consolidate slowly over time has stimulated studies revealing the hormonal and neural influences regulating memory consolidation, as well as molecular and cellular mechanisms. This review examines the progress made over the century in understanding the time-dependent processes that create our lasting memories.

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Tài liệu tham khảo

Müller G. E., Pilzecker A., Z. Psychol. 1, 1 (1900).

Glickman S. E., Psychol. Bull. 58, 218 (1961);

; J. L. McGaugh and M. J. Herz Memory Consolidation (Albion San Francisco 1972); H. Weingartner and E. S. Parker Eds. Memory Consolidation (Erlbaum Hillsdale NJ 1984);

Lechner H. A., Squire L. R., Byrne J. H., Learn. Mem. 6, 77 (1999);

Polster M. R., Nadel L., Schacter D. L., J. Cogn. Neurosci. 3, 95 (1991).

10.1126/science.153.3742.1351

Dudai Y., Neuron 17, 367 (1996).

T. Ribot Diseases of Memory (Appleton New York 1882);

McDougall W., Mind 10, 388 (1901);

Burnham W. H., Am. J. Psychol. 14, 382 (1903).

Duncan C. P., J. Comp. Physiol. Psychol. 42, 32 (1949).

Gerard R. W., Am. J. Psychiatry 106, 161 (1949).

D. O. Hebb The Organization of Behavior (Wiley New York 1949) and (7). It is of interest that Hebb did not refer to the perseveration-consolidation hypothesis in his seminal 1949 book.

Agranoff B. W., Davis R. E., Brink J. J., Brain Res. 1, 303 (1965).

J. L. McGaugh in Recent Advances in Learning and Retention D. Bovet F. Bovet-Nitti A. Oliverio Eds. (Accademia Nazionale dei Lincei Rome 1968) pp. 13–24.

McGaugh J. L., Annu. Rev. Pharmacol. 13, 229 (1973);

; Brain Res. Bull. 23 339 (1989).

Alloway T. M., Routtenberg A., Science 158, 1066 (1967);

Tully T., Preat T., Boynton S. C., Del Vecchio M., Cell 79, 35 (1994);

Menzel R., Müller U., Annu. Rev. Neurosci. 19, 379 (1966);

Müller U., Neuron 16, 1249 (1996).

Sandi C., Rose S. P. R., Brain Res. 647, 106 (1994).

P. E. Gold and J. L. McGaugh in Short - Term Memory D. Deutsch and J. A. Deutsch Eds. (Academic Press New York 1975) pp. 355–378.

S.-A. Christianson Ed. Handbook of Emotion and Memory : Current Research and Theory (Erlbaum Hillsdale NJ 1992).

Gold P. E., van Buskirk R., Behav. Biol. 13, 145 (1975).

J. L. McGaugh and P. E. Gold in Psychoendocrinology R. B. Brush and S. Levine Eds. (Academic Press New York 1989) pp. 305–339.

de Kloet E. R., Front. Neuroendocrinol. 12, 95 (1991);

___, Kock S., Schild V., Veldhuis H. D., Neuroendocrinology 47, 109 (1988);

; B. Roozendaal L. Cahill J. L. McGaugh in Brain Processes and Memory K. Ishikawa J. L. McGaugh H. Sakata Eds. (Elsevier Amsterdam 1996) pp. 39–54.

Lupien S. J., McEwen B. S., Brain Res. Rev. 24, 1 (1997).

M. G. Packard C. L. Williams L. Cahill J. L. McGaugh in Neurobehavioral Plasticity : Learning Development and Response to Brain Insults N. E. Spear L. Spear M. Woodruff Eds. (Erlbaum Hillsdale NJ 1995) pp. 149–184;

McGaugh J. L., Cahill L., Roozendaal B., Proc. Natl. Acad. Sci. U.S.A. 93, 13508 (1996);

. There is also evidence that epinephrine influences memory through the release of glucose which then enters the brain; however the effects of glucose on memory differ from those mediated by the activation of vagal afferents. P. E. Gold in Cellular Mechanisms of Conditioning and Behavioral Plasticity C. D. Woody D. L. Alkon J. L. McGaugh Eds. (Plenum New York 1988) pp. 329–341.

Liang K. C., Juler R. G., McGaugh J. L., Brain Res. 368, 125 (1986).

Roozendaal B., McGaugh J. L., Neurobiol. Learn. Mem. 65, 1 (1996);

Hatfield T., McGaugh J. L., Neurobiol. Learn. Mem. 71, 232 (1999);

Ferry B., McGaugh J. L., Neurobiol. Learn. Mem. 72, 8 (1999).

Quirarte G. L., Roozendaal B., McGaugh J. L., Proc. Natl. Acad. Sci. U.S.A. 94, 14048 (1997).

Galvez R., Mesches M., McGaugh J. L., Neurobiol. Learn. Mem. 66, 253 (1996);

10.1016/S0006-8993(98)00795-1

Williams C. L., Men D., Clayton E. C., Gold P. E., Behav. Neurosci. 112, 1414 (1998);

Hatfield T., Spanis C., McGaugh J. L., Brain Res. 835, 340 (1999).

L. R. Squire and E. R. Kandel Memory from Mind to Molecules (Scientific American Library New York 1999).

For example

Packard M. G., White N. M., Behav. Neurosci. 105, 295 (1991);

Packard M. G., Hirsh R., White N. M., J. Neurosci. 9, 1465 (1989) .

Packard M. G., Cahill L., McGaugh J. L., Proc. Natl. Acad. Sci. U.S.A. 91, 8477 (1994);

Packard M. G., Teather L., Neurobiol. Learn. Mem. 69, 163 (1998).

Roozendaal B., McGaugh J. L., Euro. J. Neurosci. 9, 76 (1997);

Roozendaal B., Nguyen B.T., Power A., McGaugh J. L., Proc. Natl. Acad. Sci. U.S.A. 96, 11642 (1999).

Ikegaya Y., Saito H., Abe K., Brain Res. 671, 351 (1995);

; Neurosci. Res. 22 203 (1995);

___, Nakanishi K., NeuroReport 8, 3143 (1997);

. BLA stimulation also induces NMDA-dependent LTP in the insular cortex a brain region known to be important for several forms of learning [

Bermudez-Rattoni F., Introini-Collison I. B., McGaugh J. L., Proc. Natl. Acad. Sci. U.S.A. 88, 5379 (1991);

Escobar M. L., Chao V., Bermudez-Rattoni F., Brain Res. 779, 314 (1998);

; M. W. Jones P. J. French T. V. P. Bliss K. Rosenblum J. Neurosci 19 RC36 (1999)].

E. Soetens S. Casaer R. D'Hooge

Hueting J. E., Psychopharmacology 119, 155 (1995).

Cahill L., Prins B., Weber M., McGaugh J. L., Nature 371, 702 (1994);

van Stegeren A. H., Everaerd W., Cahill L., McGaugh J. L., Gooren L. J. G., Psychopharmacology 138, 305 (1998);

Nielson K., Jensen R., Behav. Neural Biol. 62, 190 (1994).

Cahill L., Babinsky R., Markowitsch H. J., McGaugh J. L., Nature 377, 295 (1995);

Adolphs R., Cahill L., Schul R., Babinsky R., Learn. Mem. 4, 291 (1997).

L. Cahill et al. Proc. Natl. Acad. Sci. U.S.A. 93 8016 (1996);

Hamann S., Ely T., Grafton S., Kilts C., Nature Neurosci. 2, 289 (1999).

10.1126/science.277.5327.821

N. M. Weinberger in The Cognitive Neurosciences M. S. Gazzaniga Ed. (MIT Press Cambridge MA 1995) pp. 1071–1089;

Weinberger N. M., Trends Cogn. Sci. 2, 271 (1998);

Bjordahl T. S., Dimyan M. A., Weinberger N. M., Behav. Neurosci. 112, 467 (1998);

Galvan V. V., Chen J., Weinberger N. M., Soc. Neurosci. Abstr. 24, 1422 (1998).

Winocur G., Behav. Brain Res. 38, 145 (1990);

Zola-Morgan S., Squire L. R., Science 250, 288 (1990);

10.1126/science.1585183

Cho Y. H., Beracochea D., Jaffard R., J. Neurosci. 13, 1759 (1993);

Kim J. J., Clark R. E., Thompson R. F., Behav Neurosci. 109, 195 (1995);

Reidel G., et al., Nature Neurosci. 3, 898 (1999).

10.1136/jnnp.20.1.11

; B. Milner in Amnesia C. W. M. Whitty and O. L. Zangwill Eds. (Butterworths London 1966) pp. 109–133.

10.1016/0959-4388(95)80023-9

Tyler T. J., DiScenna P., Behav. Neurosci. 100, 147 (1986);

; J. L. McClelland B. L. McNaughton R. C. O'Reilly Psychol. Rev. 102 419 (1995).

Shors T. J., Matzel L. D., Behav. Brain Sci. 20, 597 (1997).

10.1126/science.285.5435.1870

Seidenbacher T., Reymann K. G., Balschun D., Proc. Natl. Acad. Sci U.S.A. 94, 1494 (1997).

10.1016/0006-8993(88)90008-X

Barros D. M., et al., Neurobiol. Learn. Mem. 71, 94 (1999).

P. A. Colley F. -

Sheu S., Routtenberg A., J. Neurosci. 10, 3353 (1990);

Huang Y.-Y., Colley P. A., Routtenberg A., Neuroscience 49, 819 (1992);

Jerusalinsky D., et al., Behav. Neural Biol. 61, 107 (1994).

10.1073/pnas.92.7.2446

; R. Bernabeu et al. Proc. Natl. Acad. Sci. U.S.A. 94 7041 (1997);

Schafe G. E., Nadel N. V., Sullivan G. M., Harris A., LeDoux J. E., Learn. Mem. 6, 97 (1999).

Guzowski J. F., McGaugh J. L., Proc. Natl. Acad. Sci. U.S.A. 94, 2693 (1997);

Tully T., Proc. Natl. Acad. Sci. U.S.A. 94, 4239 (1997).

A. Routtenberg in Four Decades of Memory P. E. Gold. and W. T. Greenough Eds. (American Psychological Association Washington DC in press);

10.1126/science.279.5349.338

K. J. Murphy and C. .

Regan M., Neurobiol. Learn. Mem. 70, 73 (1998);

; P. Roullet R. Mileusnic S. P. R. Rose S. J. Sara NeuroReport 8 1907 (1997).

10.1126/science.8211146

Mauelshagen J., Parker G. R., Carew T. J., J. Neurosci. 15, 7099 (1996);

Müller U., Carew T. J., Neuron 21, 1423 (1996) .

Izquierdo I., Barros D. M., Mello e Souza T., de Souza M. M., Izquierdo L. A., Nature 393, 635 (1998).

I thank L. Cahill I. Izquierdo A. Routtenberg G. Streidter and N. M. Weinberger for their helpful comments and N. Collett for assistance in preparation of the manuscript. Supported by National Institute of Mental Health grant MH12526.