Bright Light Induction of Strong (Type 0) Resetting of the Human Circadian Pacemaker

American Association for the Advancement of Science (AAAS) - Tập 244 Số 4910 - Trang 1328-1333 - 1989
Charles A. Czeisler1, Richard E. Kronauer2, James S. Allan1, Jeanne F. Duffy1, Megan E. Jewett1, Emery N. Brown1, Joseph M. Ronda1
1Center for Circadian and Sleep Disorders Medicine, Division o fEndocrinology, Department of Medicine, Harvard Medical School, Brigham and Women's Hospital, Boston, MA 02115
2Division of Applied Sciences, Harvard University, Cambridge, MA 02138.

Tóm tắt

The response of the human circadian pacemaker to light was measured in 45 resetting trials. Each trial consisted of an initial endogenous circadian phase assessment, a three-cycle stimulus which included 5 hours of bright light per cycle, and a final phase assessment. The stimulus induced strong (type 0) resetting, with responses highly dependent on the initial circadian phase of light exposure. The magnitude and direction of the phase shifts were modulated by the timing of exposure to ordinary room light, previously thought to be undetectable by the human pacemaker. The data indicate that the sensitivity of the human circadian pacemaker to light is far greater than previously recognized and have important implications for the therapeutic use of light in the management of disorders of circadian regulation.

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American Association for the Advancement of Science (AAAS)

Tập 244 Số 4910

1328-1333

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