The receptor-binding domain of the viral spike protein is an immunodominant and highly specific target of antibodies in SARS-CoV-2 patients

Science immunology - Tập 5 Số 48 - 2020
Lakshmanane Premkumar1, Bruno Segovia-Chumbez1, Ramesh Jadi1, David R. Martinez2, Rajendra Raut1, Alena J. Markmann3, Caleb Cornaby4, Luther A. Bartelt3, Susan R. Weiss3, Yara Park3, Caitlin E. Edwards2, Eric T. Weimer5, Erin M. Scherer6, Nadine Rouphael6, Srilatha Edupuganti6, Daniela Weiskopf7, Longping V. Tse2, Yixuan J. Hou2, David M. Margolis1, Alessandro Sette7,8, Matthew H. Collins6, John L. Schmitz5, Ralph S. Baric1, Aravinda M. de Silva1
1Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
2Department of Epidemiology, UNC Chapel Hill School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
3Department of Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
4Immunology/Histocompatibility and Immunogenetics Laboratories, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
5Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA
6Hope Clinic of the Emory Vaccine Center, Division of Infectious Diseases, Department of Medicine, School of Medicine, Emory University, Decatur, GA 30322, USA.
7Center for Infectious Disease and Vaccine Research, Institute for Immunology (LJI), La Jolla, La Jolla, CA 92037, USA.
8Division of Infectious Diseases and Global Public Health, Department of Medicine, University of California, San Diego (UCSD), La Jolla, CA 92037, USA

Tóm tắt

The serum level of RBD-binding antibodies correlates with SARS-CoV-2 neutralization and can be used for population-level surveillance.

Từ khóa


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Science immunology

Tập 5 Số 48

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