Is Zn2+ transported by the mitochondrial calcium uniporter?

FEBS Letters - Tập 356 - Trang 195-198 - 1994
Nils-Erik L. Saris1, Kaija Niva1
1The Helsinki Bioenergetics Group, POB 8, Department of Medical Chemistry, University of Helsinki, FIN-00014 Helsinki, Finland

Tóm tắt

Zinc ions were found to inhibit Ca2+ uptake by rat liver mitochondria driven by succinate respiration but not that by a valinomycin‐induced membrane potential. Zn2+ at 1 μM or higher concentrations induced a lowering of the membrane potential under the former but not the latter conditions. It is concluded that it is the lowered membrane potential in the presence of Zn2+ that reduces the rate of respiration‐driven Ca2+. Ruthenium red was found to inhibit the uptake of Zn2+ but had no influence on its action upon the membrane potential. Zn2+ did not affect the Ruthenium red‐insensitive Ca2+ efflux. Ca2+ stimulated the uptake of Zn2+. It is concluded that Zn2+ may be transported by the mitochondrial calcium uniporter but that it may have access to sites required for inhibition of respiration by other routes.

Tài liệu tham khảo

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FEBS Letters

Tập 356

195-198

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