SARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivo

American Association for the Advancement of Science (AAAS) - Tập 370 Số 6523 - Trang 1464-1468 - 2020
Yixuan J. Hou1, S Chiba2, Peter Halfmann2, Camille Ehré3, Makoto Kuroda2, Kenneth H. Dinnon4, Sarah R. Leist1, Alexandra Schäfer1, Noriko Nakajima5, Kenta Takahashi5, Rhianna E. Lee3, Teresa Mascenik3, Rachel L. Graham1, Caitlin E. Edwards1, Longping V. Tse1, Kenichi Okuda3, Alena J. Markmann6, Luther A. Bartelt6, Aravinda M. de Silva4, David M. Margolis1,6,4, Richard C. Boucher3, Scott H. Randell3, Tadaki Suzuki5, Lisa E. Gralinski1, Yoshihiro Kawaoka7,2, Ralph S. Baric1,4
1Department of Epidemiology; University of North Carolina at Chapel Hill; Chapel Hill; NC; USA
2Influenza Research Institute, Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI, USA.
3Marsico Lung Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
4Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
5Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
6Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
7Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

Tóm tắt

Changing with the times Pandemic spread of a virus in naïe populations can select for mutations that alter pathogenesis, virulence, and/or transmissibility. The ancestral form of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that emerged from China has now been largely replaced by strains containing the mutation D614G (Asp 614 -to-Gly) in the viral spike protein. Hou et al. compared the characteristics of the new variant against the ancestral form in a series of experiments in human cells and animal models. The variant is better at infecting upper-airway epithelial cells and replicates in greater numbers than the ancestral virus. Evidence indicates modest, if any, significant changes to virulence in animal models. Therefore, the virus appears to have evolved for greater transmissibility in humans rather than for greater pathogenicity. The mutation renders the new virus variant more susceptible to neutralizing antisera without altering the efficacy of vaccine candidates currently under development. Science , this issue p. 1464

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American Association for the Advancement of Science (AAAS)

Tập 370 Số 6523

1464-1468

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