Blast2GO: a universal tool for annotation, visualization and analysis in functional genomics research

Bioinformatics (Oxford, England) - Tập 21 Số 18 - Trang 3674-3676 - 2005
Ana Conesa1, Stefan Götz2,3, Juan M. García–Gómez1, Javier Terol1
1Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung = Alfred Wegener Institute for Polar and Marine Research = Institut Alfred-Wegener pour la recherche polaire et marine
2Evolutionary Biology and Ecology of Algae
3Pontificia Universidad Católica de Chile

Tóm tắt

AbstractSummary: We present here Blast2GO (B2G), a research tool designed with the main purpose of enabling Gene Ontology (GO) based data mining on sequence data for which no GO annotation is yet available. B2G joints in one application GO annotation based on similarity searches with statistical analysis and highlighted visualization on directed acyclic graphs. This tool offers a suitable platform for functional genomics research in non-model species. B2G is an intuitive and interactive desktop application that allows monitoring and comprehension of the whole annotation and analysis process.Availability: Blast2GO is freely available via Java Web Start at http://www.blast2go.deSupplementary material:  http://www.blast2go.de -> EvaluationContact:  [email protected]; [email protected]

Từ khóa


Tài liệu tham khảo

Al-Shahrour, F., et al. 2004FatiGO: a web tool for finding significant associations of Gene Ontology terms with groups of genes. Bioinformatics20578–580

Altschul, S.F., et al. 1990Basic local alignment search tool. J. Mol. Biol.215403–410

Ashburner, M., et al. 2000Gene Ontology: tool for the unification of biology. Nat. Genet.2525–29

Blüthgen, N., Brand, K., Cajavec, B., Swat, M., Herzel, H., Beule, D. 2004Biological Profiling of Gene Groups utilizing Gene Ontology – A Statistical Framework. arXiv:q-bio.GN/040703411

Doniger, S., et al. 2003MAPPFinder: using Gene Ontology and GenMAPP to create a global gene-expression profile from microarray data. Genome Biol.4R7

Groth, D., et al. 2004GOblet: a platform for Gene Ontology annotation of anonymous sequence data. Nucleic Acids Res.32313–317

Khan, S., et al. 2003GoFigure: automated Gene OntologyTM annotation. Bioinformatics192484–2485

Martin, D., et al. 2004GOtcha: a new method for prediction of protein function assessed by the annotation of seven genomes. BMC Bioinformatics5178

Zehetner, G. 2003OntoBlast function: from sequence similarities directly to potential functional annotations by ontology terms. Nucleic Acids Res.313799–3803

Thông tin
Thông tin xuất bản

Bioinformatics (Oxford, England)

Tập 21 Số 18

3674-3676

Thông tin tác giả