Transplacental transmission of SARS-CoV-2 infection

Nature Communications - Tập 11 Số 1
Alexandre Vivanti1, Christelle Vauloup‐Fellous2, Sophie Prévôt3, V Zupan4, Cécile Suffee5, Jérémy Do Cao6, Alexandra Benachi1, Danièle De Luca7
1Division of Obstetrics and Gynecology, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140, Clamart, France
2Division of Virology, Paul Brousse Hospital, Paris Saclay University Hospitals, APHP 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France
3Division of Pathology, Bicetre Hospital, Paris Saclay University Hospitals, APHP, Le Kremlin-Bicêtre, France
4Division of Pediatrics and Neonatal Critical Care, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140, Clamart, France
5Division of Radiology, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140, Clamart, France
6Division of General Pediatrics, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140, Clamart, France
7Physiopathology and Therapeutic Innovation Unit-INSERM U999, Paris Saclay University, 63 Rue Gabriel Péri, 94270, Le Kremlin-Bicêtre, France

Tóm tắt

AbstractSARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes: (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients.

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Tập 11 Số 1

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