Antidepressant-like activity of zinc: further behavioral and molecular evidence

Journal of Neural Transmission - Tập 115 - Trang 1621-1628 - 2008
Magdalena Sowa-Kućma1, Beata Legutko1,2, Bernadeta Szewczyk1, Kinga Novak1, Paweł Znojek1,3, Ewa Poleszak4, Mariusz Papp1, Andrzej Pilc1,5, Gabriel Nowak1,6
1Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland
2Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, USA
3Northern Institute for Cancer Research, Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, UK
4Department of Pharmacology and Pharmacodynamics, Skubiszewski Medical University of Lublin, Lublin, Poland
5Institute of Public Health, Collegium Medicum, Jagiellonian University, Kraków, Poland
6Department of Cytobiology and Histochemistry, Collegium Medicum, Jagiellonian University, Kraków, Poland

Tóm tắt

Zinc exhibits antidepressant-like activity in preclinical tests (the forced swim test and tail suspension test) and in olfactory bulbectomy and chronic unpredictable stress; two models of depression. Zinc also enhances the treatment of depression in humans. In the present study we evaluated the antidepressant activity of zinc in another model of depression—chronic mild stress (CMS) and the effect of zinc treatment on BDNF protein and the mRNA level. In CMS zinc hydroaspartate (10 mg/kg) exhibited a rapid (after 1 week of treatment) antidepressant-like effect. Chronic treatment with zinc induced a 17–39% increase in the BDNF mRNA and protein level in the hippocampus. These data indicate a rapidly acting antidepressant-like activity of zinc in CMS and the involvement of zinc in the regulation of BDNF.

Tài liệu tham khảo

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