Chaya (Jatropha tanjorensis) leafs protect against sodium benzoate mediated renal dysfunction and hepatic damage in rats

Springer Science and Business Media LLC - Tập 6 - Trang 1-8 - 2020
Johnson Olaleye Oladele1, Oluwaseun Titilope Oladele2, Adedayo Oluwaseun Ademiluyi3, Oyedotun Moses Oyeleke1,2, Olaide Oladimeji Awosanya1, Olu Israel Oyewole2
1Department of Chemical Sciences, Faculty of Science, Kings University, Ode-Omu, Nigeria
2Phytomedicine and Toxicology Laboratories, Department of Biochemistry, Faculty of Basic and Applied Sciences, Osun State University, Osogbo, Nigeria
3Department of Biochemistry, Functional Foods and Nutraceuticals Unit, Federal University of Technology, Akure, Nigeria

Tóm tắt

Jatropha tanjorensis is a commonly consumed green leafy plant that has found usage in folk medicine. Sodium benzoate (C6H5COONa) is a widely used preservative in food/drink industries with potential cytotoxicity. Protective effect of some leafy plants on xenobiotic-induced toxicity have been established. Hence, this study sought to investigate the protective effect of methanolic leaf extract of Jatropha tanjorensis on sodium benzoate mediated renal and hepatic dysfunction in rats. Sodium benzoate treatment caused significant (P < 0.05) alteration in kidney (serum urea, uric acid, and creatinine) and liver (aspartate and alanine transaminases, acid and alkaline phosphatases) damage markers, serum albumin, globulin and total protein levels as well as cellular architecture which were significantly reversed in groups treated with the leaf extracts. Phytochemical screening of the leaf extract revealed the presence of terpenoids, saponins, cardiac glycosides, flavonoids and tannins. Sodium benzoate-induced alterations in the renal and hepatic indices were mitigated following treatment with J. tanjorensis leaf extracts which suggests protective effect of the extract against sodium benzoate intoxication.

Tài liệu tham khảo

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