Drug-Induced Changes in the Liver Endoplasmic Reticulum: Association with Drug-Metabolizing Enzymes

American Association for the Advancement of Science (AAAS) - Tập 142 Số 3600 - Trang 1657-1658 - 1963
H. Remmer1, H. J. Merker1
1Department of Pharmacology and Institute for Electronmicroscopy, Freien Universiät, Berlin-Dahlem, Germany

Tóm tắt

The cellular changes which lead to the increase of drug-metabolizing enzymes following drug administration are explained by correlating new biochemical data with previously reported electron microscopic and pharmacologic observations. Repeated administration of phenobarbital and several other drugs results in a quantitative increase of the smooth endoplasmic reticulum of the liver cell. The marked increase in drug-metabolizing enzymes is found to occur in this enlarged smooth membrane fraction of the endoplasmic reticulum.

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Tài liệu tham khảo

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Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 142 Số 3600

1657-1658

Thông tin tác giả