Rapidly Generated Multivirus-specific Cytotoxic T Lymphocytes for the Prophylaxis and Treatment of Viral Infections

Schönberger, 2010, Prospective, comprehensive, and effective viral monitoring in children undergoing allogeneic hematopoietic stem cell transplantation, Biol Blood Marrow Transplant, 16, 1428, 10.1016/j.bbmt.2010.04.008 Verdeguer, 2011, Observational prospective study of viral infections in children undergoing allogeneic hematopoietic cell transplantation: a 3-year GETMON experience, Bone Marrow Transplant, 46, 119, 10.1038/bmt.2010.52 Lang, 2008, Haploidentical SCT in children: an update and future perspectives, Bone Marrow Transplant, 42, S54, 10.1038/bmt.2008.285 Sauter, 2011, Serious infection risk and immune recovery after double-unit cord blood transplantation without antithymocyte globulin, Biol Blood Marrow Transplant, 17, 1460, 10.1016/j.bbmt.2011.02.001 Hantz, 2010, Drug-resistant cytomegalovirus in transplant recipients: a French cohort study, J Antimicrob Chemother, 65, 2628, 10.1093/jac/dkq368 Ljungman, 2003, Cidofovir for adenovirus infections after allogeneic hematopoietic stem cell transplantation: a survey by the Infectious Diseases Working Party of the European Group for Blood and Marrow Transplantation, Bone Marrow Transplant, 31, 481, 10.1038/sj.bmt.1703798 Heslop, 1994, Donor T cells to treat EBV-associated lymphoma, N Engl J Med, 331, 679, 10.1056/NEJM199409083311017 Leen, 2006, Monoculture-derived T lymphocytes specific for multiple viruses expand and produce clinically relevant effects in immunocompromised individuals, Nat Med, 12, 1160, 10.1038/nm1475 Leen, 2009, Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation, Blood, 114, 4283, 10.1182/blood-2009-07-232454 Haque, 2007, Allogeneic cytotoxic T-cell therapy for EBV-positive posttransplantation lymphoproliferative disease: results of a phase 2 multicenter clinical trial, Blood, 110, 1123, 10.1182/blood-2006-12-063008 Kedl, 2000, T cells compete for access to antigen-bearing antigen-presenting cells, J Exp Med, 192, 1105, 10.1084/jem.192.8.1105 Kedl, 2002, T cells down-modulate peptide-MHC complexes on APCs in vivo, Nat Immunol, 3, 27, 10.1038/ni742 Cobbold, 2005, Adoptive transfer of cytomegalovirus-specific CTL to stem cell transplant patients after selection by HLA-peptide tetramers, J Exp Med, 202, 379, 10.1084/jem.20040613 Feuchtinger, 2006, Safe adoptive transfer of virus-specific T-cell immunity for the treatment of systemic adenovirus infection after allogeneic stem cell transplantation, Br J Haematol, 134, 64, 10.1111/j.1365-2141.2006.06108.x Feuchtinger, 2010, Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation, Blood, 116, 4360, 10.1182/blood-2010-01-262089 Khanna, 2011, Generation of a multipathogen-specific T-cell product for adoptive immunotherapy based on activation-dependent expression of CD154, Blood, 118, 1121, 10.1182/blood-2010-12-322610 Leen, 2004, Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications, Blood, 103, 1011, 10.1182/blood-2003-07-2449 Leen, 2008, Identification of hexon-specific CD4 and CD8 T-cell epitopes for vaccine and immunotherapy, J Virol, 82, 546, 10.1128/JVI.01689-07 Hislop, 2007, Cellular responses to viral infection in humans: lessons from Epstein-Barr virus, Annu Rev Immunol, 25, 587, 10.1146/annurev.immunol.25.022106.141553 Badr, 2008, Early interferon therapy for hepatitis C virus infection rescues polyfunctional, long-lived CD8+ memory T cells, J Virol, 82, 10017, 10.1128/JVI.01083-08 Kannanganat, 2007, Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells, J Virol, 81, 8468, 10.1128/JVI.00228-07 Leen, 2001, Differential immunogenicity of Epstein-Barr virus latent-cycle proteins for human CD4(+) T-helper 1 responses, J Virol, 75, 8649, 10.1128/JVI.75.18.8649-8659.2001 Heslop, 1996, Long-term restoration of immunity against Epstein-Barr virus infection by adoptive transfer of gene-modified virus-specific T lymphocytes, Nat Med, 2, 551, 10.1038/nm0596-551 Gotch, 1987, Identification of viral molecules recognized by influenza-specific human cytotoxic T lymphocytes, J Exp Med, 165, 408, 10.1084/jem.165.2.408 McMichael, 1981, The human cytotoxic T cell response to influenza A vaccination, Clin Exp Immunol, 43, 276 Bunde, 2005, Protection from cytomegalovirus after transplantation is correlated with immediate early 1-specific CD8 T cells, J Exp Med, 201, 1031, 10.1084/jem.20042384 Bickham, 2001, EBNA1-specific CD4+ T cells in healthy carriers of Epstein-Barr virus are primarily Th1 in function, J Clin Invest, 107, 121, 10.1172/JCI10209 Münz, 2000, Human CD4(+) T lymphocytes consistently respond to the latent Epstein-Barr virus nuclear antigen EBNA1, J Exp Med, 191, 1649, 10.1084/jem.191.10.1649 Balduzzi, 2011, Polyomavirus JC-targeted T-cell therapy for progressive multiple leukoencephalopathy in a hematopoietic cell transplantation recipient, Bone Marrow Transplant, 46, 987, 10.1038/bmt.2010.221 Rock, 2011, Identification of potential human respiratory syncytial virus and metapneumovirus T cell epitopes using computational prediction and MHC binding assays, J Immunol Methods, 374, 13, 10.1016/j.jim.2011.08.004 Shao, 2011, Immunoprotectivity of HLA-A2 CTL peptides derived from respiratory syncytial virus fusion protein in HLA-A2 transgenic mouse, PLoS ONE, 6, e25500, 10.1371/journal.pone.0025500 Feuchtinger, 2008, Clinical grade generation of hexon-specific T cells for adoptive T-cell transfer as a treatment of adenovirus infection after allogeneic stem cell transplantation, J Immunother, 31, 199, 10.1097/CJI.0b013e31815ef862 Gerdemann, 2009, Nucleofection of DCs to generate Multivirus-specific T cells for prevention or treatment of viral infections in the immunocompromised host, Mol Ther, 17, 1616, 10.1038/mt.2009.140 Heslop, 2010, Long-term outcome of EBV-specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients, Blood, 115, 925, 10.1182/blood-2009-08-239186 Kenter, 2009, Vaccination against HPV-16 oncoproteins for vulvar intraepithelial neoplasia, N Engl J Med, 361, 1838, 10.1056/NEJMoa0810097 Maecker, 2001, Use of overlapping peptide mixtures as antigens for cytokine flow cytometry, J Immunol Methods, 255, 27, 10.1016/S0022-1759(01)00416-1 Kozlowski, 1993, Multiple pathways are involved in the extracellular processing of MHC class I-restricted peptides, J Immunol, 151, 4033, 10.4049/jimmunol.151.8.4033 Toes, 1998, Enhancement of tumor outgrowth through CTL tolerization after peptide vaccination is avoided by peptide presentation on dendritic cells, J Immunol, 160, 4449, 10.4049/jimmunol.160.9.4449 Sherman, 1992, Extracellular processing of peptide antigens that bind class I major histocompatibility molecules, J Exp Med, 175, 1221, 10.1084/jem.175.5.1221 Larsen, 1996, T cell responses affected by aminopeptidase N (CD13)-mediated trimming of major histocompatibility complex class II-bound peptides, J Exp Med, 184, 183, 10.1084/jem.184.1.183 Rosenberg, 1994, Treatment of patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and interleukin 2, J Natl Cancer Inst, 86, 1159, 10.1093/jnci/86.15.1159 Becker, 2002, Interleukin 15 is required for proliferative renewal of virus-specific memory CD8 T cells, J Exp Med, 195, 1541, 10.1084/jem.20020369 Vella, 1998, Cytokine-induced survival of activated T cells in vitro and in vivo, Proc Natl Acad Sci USA, 95, 3810, 10.1073/pnas.95.7.3810 Tan, 2002, Interleukin (IL)-15 and IL-7 jointly regulate homeostatic proliferation of memory phenotype CD8+ cells but are not required for memory phenotype CD4+ cells, J Exp Med, 195, 1523, 10.1084/jem.20020066 Melchionda, 2005, Adjuvant IL-7 or IL-15 overcomes immunodominance and improves survival of the CD8+ memory cell pool, J Clin Invest, 115, 1177, 10.1172/JCI200523134 Chetoui, 2010, Interleukin-7 promotes the survival of human CD4+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway, Immunology, 130, 418, 10.1111/j.1365-2567.2009.03244.x Sportès, 2010, Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy, Clin Cancer Res, 16, 727, 10.1158/1078-0432.CCR-09-1303 Majhail, 2004, Phase I trial of continuous infusion recombinant human interleukin-4 in patients with cancer, Invest New Drugs, 22, 421, 10.1023/B:DRUG.0000036684.67675.fe von Rossum, 2011, Inflammatory cytokines determine the susceptibility of human CD8 T cells to Fas-mediated activation-induced cell death through modulation of FasL and c-FLIP(S) expression, J Biol Chem, 286, 21137, 10.1074/jbc.M110.197657 Maus, 2002, Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB, Nat Biotechnol, 20, 143, 10.1038/nbt0202-143