A Biosynthetic Alternative to Human Donor Tissue for Inducing Corneal Regeneration: 24-Month Follow-Up of a Phase 1 Clinical Study
Tóm tắt
A biosynthetic cornea is stably integrated with host tissues for 2 years after implantation and produces nerve regeneration and vision improvement.
Từ khóa
Tài liệu tham khảo
Whitcher J. P., Srinivasan M., Upadhyay M. P., Corneal blindness: A global perspective. Bull. World Health Organ. 79, 214–221 (2001).
M. A. Princz H. Sheardown M. Griffith Corneal tissue engineering versus synthetic artificial corneas in Biomaterials and Regenerative Medicine in Ophthalmology T. V. Chirila Ed. (CRC Press/Woodhead Publishing Cambridge UK 2009).
T. Nishida Cornea: Fundamentals of cornea and external disease in Cornea J. J. Krachmer M. J. Mannis E. J. Holland Eds. (Mosby-Year Book St. Louis MO 1997) pp. 3–26.
Lagali N., Griffith M., Fagerholm P., Merrett K., Huynh M., Munger R., Innervation of tissue-engineered recombinant human collagen-based corneal substitutes: A comparative in vivo confocal microscopy study. Invest. Ophthalmol. Vis. Sci. 49, 3895–3902 (2008). [PubMed]
I. V. Yannas Biologically active scaffolds based on collagen-GAG copolymers in Scaffolding in Tissue Engineering P. X. Ma J. Elisseeff Eds. (CRC Press Boca Raton FL 2006) pp. 3–12.
Richter A., Slowik C., Somodi S., Vick H. P., Guthoff R., Corneal reinnervation following penetrating keratoplasty—correlation of esthesiometry and confocal microscopy. Ger. J. Ophthalmol. 5, 513–517 (1996).