The early spread and epidemic ignition of HIV-1 in human populations

American Association for the Advancement of Science (AAAS) - Tập 346 Số 6205 - Trang 56-61 - 2014
Nuno R. Faria1,2, Andrew Rambaut3,4,5, Marc A. Suchard6,7, Guy Baele2, Trevor Bedford8, Melissa J. Ward5, Andrew J. Tatem9,10, João Sousa11,2, Nimalan Arinaminpathy1, Jacques Pépin12, David Posada13, Martine Peeters14, Oliver G. Pybus1, Philippe Lemey2
1Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK
2KU Leuven - University of Leuven, Department of Microbiology and Immunology, Rega Institute for Medical Research, Clinical and Epidemiological Virology, Minderbroedersstraat 10, B-3000 Leuven, Belgium.
3Centre for Immunity, Infection and Evolution, University of Edinburgh, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK.
4Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA
5Institute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Kings Buildings, West Mains Road, Edinburgh EH9 3JT, UK.
6Department of Biostatistics, UCLA Fielding School of Public Health, University of California, Los Angeles, CA 90095-1766, USA.
7Departments of Biomathematics and Human Genetics, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA 90095-1766, USA.
8Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
9Department of Geography and Environment, University of Southampton, Highfield, Southampton, UK
10Fogarty International Center, National Institutes of Health, Bethesda, MD 20892, USA. Department of Geography and Environment, University of Southampton, Highfield, Southampton, UK.
11Centro de Malária e outras Doenças Tropicais and Unidade de Microbiologia, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 100, 1349-008 Lisbon, Portugal.
12Department of Microbiology and Infectious Diseases, Université de Sherbrooke, CHUS, 3001, 12ème Avenue Nord, Sherbrooke, QC J1H 5N4, Canada.
13Department of Biochemistry, Genetics and Immunology, University of Vigo, Vigo 36310, Spain.
14Laboratoire Retrovirus, UMI233, Institut de Recherche pour le Développement and University of Montpellier, 911 Avenue Agropolis, BP5045, 34032 Montpellier, France.

Tóm tắt

The hidden history of the HIV pandemic

Rail and river transport in 1960s Congo, combined with the sexual revolution and changes in health care practices, primed the HIV pandemic. Faria et al. unpick the circumstances surrounding the ascendancy of HIV from its origins before 1920 in chimpanzee hunters in the Cameroon to amplification in Kinshasa. Around 1960, rail links promoted the spread of the virus to mining areas in southeastern Congo and beyond. Ultimately, HIV crossed the Atlantic in Haitian teachers returning home. From those early events, a pandemic was born.

Science , this issue p. 56

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American Association for the Advancement of Science (AAAS)

Tập 346 Số 6205

56-61

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