Mechanisms for Contractile Effect of Dai-kenchu-to in Isolated Guinea Pig Ileum

Digestive Diseases and Sciences - Tập 46 - Trang 250-256 - 2001
Kazuko Satoh1,2, Terumasa Hayakawa1,2, Yoshio Kase1,2, Atsushi Ishige1,2, Hiroshi Sasaki1,2, Shigeto Nishikawa1,2, Susumu Kurosawa1,2, Koji Yakabi1,2, Takashi Nakamura1,2
1Kampo & Pharmacognosy Laboratory, R & D Division, Tsumura & Co., Inashiki-gun, Ibaraki, Japan
2The Third Department of Internal Medicine, Teikyo University, School of Medicine (Ichihara Hospital), Ichihara-shi, Chiba, Japan

Tóm tắt

The mechanisms by which Dai-kenchu-to (TJ-100), a kampo medicine, enhances gastrointestinal motility was investigated using isolated guinea pig ileum. TJ-100 induced contractions accompanied by autonomous contraction at a concentration of more than 3 × 10−4 g/ml in a dose-related manner. The TJ-100-induced ileal contraction was suppressed by atropine and tetrodotoxin, but not by hexamethonium. This effect was partially suppressed in the presence of high concentrations of ICS 205-930, a serotonin 4 (5-HT4) receptor antagonist. In addition, TJ-100 showed an acetylcholine (ACh) -releasing action in the smooth muscle tissues of ileum. These results suggest that contractile response induced by TJ-100 is partially mediated by ACh released from the cholinergic nerve endings and that 5-HT4 receptors would be involved in the effect of TJ-100.

Tài liệu tham khảo

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