The dynorphin/kappa opioid system as a modulator of stress-induced and pro-addictive behaviors
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Aston-Jones, 2009, Role of lateral hypothalamic orexin neurons in reward processing and addiction, Neuropharmacology, 56, 112, 10.1016/j.neuropharm.2008.06.060
Bale, 2005, Sensitivity to stress: dysregulation of CRF pathways and disease development, Horm. Behav., 48, 1, 10.1016/j.yhbeh.2005.01.009
Bale, 2004, CRF and CRF receptors: role in stress responsivity and other behaviors, Annu. Rev. Pharmacol. Toxicol., 44, 525, 10.1146/annurev.pharmtox.44.101802.121410
Bals-Kubik, 1993, Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats, J. Pharmacol. Exp. Ther., 264, 489
Bausch, 1997, Changes in hippocampal circuitry after pilocarpine-induced seizures as revealed by opioid receptor distribution and activation, J. Neurosci., 17, 477, 10.1523/JNEUROSCI.17-01-00477.1997
Beardsley, 2005, Differential effects of the novel kappa opioid receptor antagonist, JDTic, on reinstatement of cocaine-seeking induced by footshock stressors vs cocaine primes and its antidepressant-like effects in rats, Psychopharmacology (Berl)., 183, 118, 10.1007/s00213-005-0167-4
Belcheva, 1998, Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits, J. Neurochem., 70, 635, 10.1046/j.1471-4159.1998.70020635.x
Belcheva, 2005, Mu and kappa opioid receptors activate ERK/MAPK via different protein kinase C isoforms and secondary messengers in astrocytes, J. Biol. Chem., 280, 27662, 10.1074/jbc.M502593200
Bilkei-Gorzo, 2008, Control of hormonal stress reactivity by the endogenous opioid system, Psychoneuroendocrinology, 33, 425, 10.1016/j.psyneuen.2007.12.010
Blendy, 2006, The role of CREB in depression and antidepressant treatment, Biol. Psychiatry, 59, 1144, 10.1016/j.biopsych.2005.11.003
Brar, 2004, Specificity and regulation of extracellularly regulated kinase1/2 phosphorylation through corticotropin-releasing factor (CRF) receptors 1 and 2beta by the CRF/urocortin family of peptides, Endocrinology, 145, 1718, 10.1210/en.2003-1023
Broom, 2002, Nonpeptidic delta-opioid receptor agonists reduce immobility in the forced swim assay in rats, Neuropsychopharmacology, 26, 744, 10.1016/S0893-133X(01)00413-4
Bruchas, 2006, Kappa opioid receptor activation of p38 MAPK is GRK3- and arrestin-dependent in neurons and astrocytes, J. Biol. Chem., 281, 18081, 10.1074/jbc.M513640200
Bruchas, 2007, Stress-induced p38 mitogen-activated protein kinase activation mediates kappa-opioid-dependent dysphoria, J. Neurosci., 27, 11614, 10.1523/JNEUROSCI.3769-07.2007
Bruchas, 2007, Long-acting kappa opioid antagonists disrupt receptor signaling and produce noncompetitive effects by activating c-Jun N-terminal kinase, J. Biol. Chem., 282, 29803, 10.1074/jbc.M705540200
Bruchas, 2008, Repeated swim stress induces kappa opioid-mediated activation of extracellular signal-regulated kinase 1/2, Neuroreport, 19, 1417, 10.1097/WNR.0b013e32830dd655
Cador, 1992, Corticotropin-releasing factor induces a place aversion independent of its neuroendocrine role, Brain Res., 597, 304, 10.1016/0006-8993(92)91487-Y
Carey, 2007, Reinstatement of cocaine place-conditioning prevented by the peptide kappa-opioid receptor antagonist arodyn, Eur. J. Pharmacol., 569, 84, 10.1016/j.ejphar.2007.05.007
Carey, 2009, Endogenous kappa opioid activation mediates stress-induced deficits in learning and memory, J. Neurosci., 29, 4293, 10.1523/JNEUROSCI.6146-08.2009
Carlezon, 2005, The many faces of CREB, Trends Neurosci., 28, 436, 10.1016/j.tins.2005.06.005
Carlezon, 1998, Regulation of cocaine reward by CREB, Science, 282, 2272, 10.1126/science.282.5397.2272
Chavkin, 1981, Demonstration of a specific dynorphin receptor in guinea pig ileum myenteric plexus, Nature, 18, 2
Chavkin, 1982, Dynorphin is a specific endogenous ligand of the kappa opioid receptor, Science, 215, 413, 10.1126/science.6120570
Chou, 2001, Orexin (hypocretin) neurons contain dynorphin, J. Neurosci., 21, RC168, 10.1523/JNEUROSCI.21-19-j0003.2001
Cone, 1983, Regional distribution of dynorphin and neo-endorphin peptides in rat brain, spinal cord, and pituitary, J. Neurosci., 11, 2146, 10.1523/JNEUROSCI.03-11-02146.1983
Contarino, 2005, The corticotropin-releasing factor receptor-1 pathway mediates the negative affective states of opiate withdrawal, Proc. Natl. Acad. Sci. U. S. A., 102, 18649, 10.1073/pnas.0506999102
Cox, 1983, Comparison of dynorphin-selective Kappa receptors in mouse vas deferens and guinea pig ileum. Spare receptor fraction as a determinant of potency, Mol. Pharmacol., 23, 36
Dautzenberg, 2002, The CRF peptide family and their receptors: yet more partners discovered, Trends Pharmacol. Sci., 23, 71, 10.1016/S0165-6147(02)01946-6
Dautzenberg, 2000, Functional characterization of corticotropin-releasing factor type 1 receptor endogenously expressed in human embryonic kidney 293 cells, Eur. J. Pharmacol., 390, 51, 10.1016/S0014-2999(99)00915-2
Der-Avakian, 2007, The effects of a single session of inescapable tailshock on the subsequent locomotor response to brief footshock and cocaine administration in rats, Psychopharmacology (Berl), 191, 899, 10.1007/s00213-006-0677-8
Dhawan, 1996, International Union of Pharmacology. XII. Classification of opioid receptors, Pharmacol. Rev., 48, 567
Dietz, 2007, Corticosterone fails to produce conditioned place preference or conditioned place aversion in rats, Behav. Brain Res., 181, 287, 10.1016/j.bbr.2007.04.005
Dinieri, 2009, Altered sensitivity to rewarding and aversive drugs in mice with inducible disruption of cAMP response element-binding protein function within the nucleus accumbens, J. Neurosci., 29, 1855, 10.1523/JNEUROSCI.5104-08.2009
Drake, 2007, Opioid systems in the dentate gyrus, Prog. Brain Res., 163, 245, 10.1016/S0079-6123(07)63015-5
Erb, 1998, The role of corticotropin-releasing factor and corticosterone in stress- and cocaine-induced relapse to cocaine seeking in rats, J. Neurosci., 18, 5529, 10.1523/JNEUROSCI.18-14-05529.1998
Erb, 2001, A role for the CRF-containing pathway from central nucleus of the amygdala to bed nucleus of the stria terminalis in the stress-induced reinstatement of cocaine seeking in rats, Psychopharmacology (Berl), 158, 360, 10.1007/s002130000642
Erspamer, 1980, Sauvagine, a new polypeptide from Phyllomedusa sauvagei skin. Occurrence in various Phyllomedusa species and pharmacological actions on rat blood pressure and diuresis, Naunyn Schmiedebergs Arch Pharmacol., 312, 265, 10.1007/BF00499156
Funk, 2007, Corticotropin-releasing factor 1 antagonists selectively reduce ethanol self-administration in ethanol-dependent rats, Biol. Psychiatry, 61, 78, 10.1016/j.biopsych.2006.03.063
Galeote, 2009, Prodynorphin gene disruption increases the sensitivity to nicotine self-administration in mice, Int. J. Neuropsychopharmacol., 12, 615, 10.1017/S1461145708009450
Gold, 2002, Organization of the stress system and its dysregulation in melancholic and atypical depression: high vs low CRH/NE states, Mol. Psychiatry, 7, 254, 10.1038/sj.mp.4001032
Goldstein, 1979, Dynorphin-(1-13), an extraordinarily potent opioid peptide, Proc. Natl. Acad. Sci. U. S. A., 76, 6666, 10.1073/pnas.76.12.6666
Goldstein, 1981, Porcine pituitary dynorphin: complete amino acid sequence of the biologically active heptadecapeptide, Proc. Natl. Acad. Sci. U. S. A., 78, 10.1073/pnas.78.11.7219
Greenwell, 2009, Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats, Addict. Biol., 14, 130, 10.1111/j.1369-1600.2008.00142.x
Grossman, 1983, The neuroendocrinology of opioid peptides, Br. Med. Bull., 39, 83, 10.1093/oxfordjournals.bmb.a071796
Gunne, 1977, Naloxone-induced reversal of schizophrenic hallucinations, J. Neural. Transm., 40, 13, 10.1007/BF01250276
Heidbreder, 1993, The kappa-opioid receptor agonist U-69593 attenuates cocaine-induced behavioral sensitization in the rat, Brain Res., 616, 335, 10.1016/0006-8993(93)90228-F
Heikkilä, 1990, Dynorphin A and substance P in the cerebrospinal fluid of schizophrenic patients, Psychiatry Res., 34, 229, 10.1016/0165-1781(90)90001-L
Herman, 1985, Antinociception and paralysis induced by intrathecal dynorphin A, J. Pharmacol. Exp. Ther., 232, 27
Houser, 1992, Morphological changes in the dentate gyrus in human temporal lobe epilepsy, Epilepsy Res. Suppl., 7, 223
Howell, 2006, Effects of genetically altered brain glucocorticoid receptor action on behavior and adrenal axis regulation in mice, Front Neuroendocrinol., 27, 275, 10.1016/j.yfrne.2006.05.001
Iyengar, 1986, Kappa opiate agonists modulate the hypothalamic–pituitary–adrenocortical axis in the rat, J. Pharmacol. Exp. Ther., 238, 429
Jiang, 1989, Elevated dynorphin in the hippocampal formation of aged rats: relation to cognitive impairment on a spatial learning task, Proc. Natl. Acad. Sci. U. S. A., 86, 2948, 10.1073/pnas.86.8.2948
Kim, 2004, A single cocaine exposure enhances both opioid reward and aversion through a ventral tegmental area-dependent mechanism, Proc. Natl. Acad. Sci. U. S. A., 101, 5664, 10.1073/pnas.0401373101
Knoll, 2007, Anxiolytic-like effects of kappa-opioid receptor antagonists in models of unlearned and learned fear in rats, J. Pharmacol. Exp. Ther., 323, 838, 10.1124/jpet.107.127415
Koob, 2008, A role for brain stress systems in addiction, Neuron, 59, 11, 10.1016/j.neuron.2008.06.012
Koob, 2007, Stress, dysregulation of drug reward pathways, and the transition to drug dependence, Am. J. Psychiatry, 164, 10.1176/appi.ajp.2007.05030503
Koob, 2008, Addiction and the brain antireward system, Annu. Rev. Psychol., 59, 29, 10.1146/annurev.psych.59.103006.093548
Kreek, 1998, Drug dependence: stress and dysregulation of brain reward pathways, Drug. Alcohol. Depend., 51, 23, 10.1016/S0376-8716(98)00064-7
Kreek, 2009, Bidirectional translation research: progress in understanding addictive diseases, Neuropharmacolgy, 56, 32, 10.1016/j.neuropharm.2008.07.042
Kreibich, 2004, cAMP response element-binding protein is required for stress but not cocaine-induced reinstatement, J. Neurosci., 24, 6686, 10.1523/JNEUROSCI.1706-04.2004
Kreibich, 2008, Presynaptic inhibition of diverse afferents to the locus coeruleus by kappa-opiate receptors: a novel mechanism for regulating the central norepinephrine system, J. Neurosci., 28, 6516, 10.1523/JNEUROSCI.0390-08.2008
Land, 2008, The dysphoric component of stress is encoded by activation of the dynorphin kappa-opioid system, J. Neurosci., 28, 407, 10.1523/JNEUROSCI.4458-07.2008
Land, 2008, Distinct roles for CRF receptor subtypes 1 and 2 in producing dynorphin/kappa opioid receptor-dependent anxiety and conditioned place aversion, Abstr. Soc. Neurosci., 34, 187.1
Lê, 2000, The role of corticotrophin-releasing factor in stress-induced relapse to alcohol-seeking behavior in rats, Psychopharmacology (Berl), 150, 317, 10.1007/s002130000411
Leander, 1983, Further study of kappa opioids on increased urination, J. Pharmaol. Exp. Ther., 227, 35
Li, 2006, Differential target-dependent actions of coexpressed inhibitory dynorphin and excitatory hypocretin/orexin neuropeptides, J. Neurosci., 26, 13037, 10.1523/JNEUROSCI.3380-06.2006
Liu, 2005, Chronic cocaine administration switches corticotropin-releasing factor2 receptor-mediated depression to facilitation of glutamatergic transmission in the lateral septum, J. Neurosci., 25, 577, 10.1523/JNEUROSCI.4196-04.2005
Mague, 2003, Antidepressant-like effects of kappa-opioid receptor antagonists in the forced swim test in rats, J. Pharmacol. Exp. Ther., 305, 323, 10.1124/jpet.102.046433
Margolis, 2003, Kappa-opioid agonists directly inhibit midbrain dopaminergic neurons, J. Neurosci., 23, 9981, 10.1523/JNEUROSCI.23-31-09981.2003
McEwen, 1998, Stress, adaptation, and disease. Allostasis and allostatic load, Ann. N.Y. Acad. Sci., 840, 33, 10.1111/j.1749-6632.1998.tb09546.x
McLaughlin, 2003, Kappa opioid receptor antagonism and prodynorphin gene disruption block stress-induced behavioral responses, J. Neurosci., 23, 5674, 10.1523/JNEUROSCI.23-13-05674.2003
McLaughlin, 2003, Phosphorylation of a carboxyl-terminal serine within the kappa-opioid receptor produces desensitization and internalization, J. Biol. Chem., 278, 34631, 10.1074/jbc.M304022200
McLaughlin, 2004, Prolonged kappa opioid receptor phosphorylation mediated by G-protein receptor kinase underlies sustained analgesic tolerance, J. Biol. Chem., 279, 1810, 10.1074/jbc.M305796200
McLaughlin, 2006, Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning, Neuropsychopharmacology, 31, 787, 10.1038/sj.npp.1300860
McLaughlin, 2006, Social defeat stress-induced behavioral responses are mediated by the endogenous kappa opioid system, Neuropsychopharmacology, 31, 1241, 10.1038/sj.npp.1300872
McLaughlin, 2006, Prior activation of kappa opioid receptors by U50,488 mimics repeated forced swim stress to potentiate cocaine place preference conditioning, Neuropsychopharmacology, 31, 787, 10.1038/sj.npp.1300860
McLennan, 2008, Kappa opioids promote the proliferation of astrocytes via Gbetagamma and beta-arrestin 2-dependent MAPK-mediated pathways, J. Neurochem., 107, 1753, 10.1111/j.1471-4159.2008.05745.x
Miczek, 2008, Social stress, therapeutics and drug abuse: preclinical models of escalated and depressed intake, Pharmacol. Ther., 120, 102, 10.1016/j.pharmthera.2008.07.006
Nabeshima, 1992, Stress-induced changes in brain Met-enkephalin, Leu-enkephalin and dynorphin concentrations, Life. Sci., 51, 211, 10.1016/0024-3205(92)90077-3
Nestler, 2006, The mesolimbic dopamine reward circuit in depression, Biol. Psychiatry, 59, 1151, 10.1016/j.biopsych.2005.09.018
Newton, 2002, Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect, J. Neurosci., 22, 10883, 10.1523/JNEUROSCI.22-24-10883.2002
Nikolarakis, 1986, Stimulation of hypothalamic beta-endorphin and dynorphin release by corticotropin-releasing factor (in vitro), Brain Res., 399, 152, 10.1016/0006-8993(86)90610-4
Papaleo, 2007, Disruption of the CRF/CRF1 receptor stress system exacerbates the somatic signs of opiate withdrawal, Neuron, 53, 577, 10.1016/j.neuron.2007.01.022
Perrin, 1998, The first extracellular domain of corticotropin releasing factor-R1 contains major binding determinants for urocortin and astressin, Endocrinology, 139, 566, 10.1210/endo.139.2.5757
Piazza, 1990, Individual reactivity to novelty predicts probability of amphetamine self-administration, Behav. Pharmacol., 1, 339, 10.1097/00008877-199000140-00007
Pfeiffer, 1986, Psychotomimesis mediated by kappa opiate receptors, Science, 233, 774, 10.1126/science.3016896
Pliakas, 2001, Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens, J. Neurosci., 21, 7397, 10.1523/JNEUROSCI.21-18-07397.2001
Redila, 2008, Stress-induced reinstatement of cocaine seeking is mediated by the kappa opioid system, Psychopharmacology (Berl), 200, 59, 10.1007/s00213-008-1122-y
Reyes, 2009, Subcellular targeting of kappa-opioid receptors in the rat nucleus locus coeruleus, J. Comp. Neurol., 512, 419, 10.1002/cne.21880
Rivier, 1983, In vitro and in vivo ACTH-releasing activity of ovine CRF, sauvagine and urotensin 1, Regul. Pept., 5, 139, 10.1016/0167-0115(83)90121-0
Rockman, 2005, Ancient and recent positive selection transformed opioid cis-regulation in humans, PLoS Biol., e387, 3
Roth, 2002, Salvinorin A: a potent naturally occurring nonnitrogenous kappa opioid selective agonist, Proc. Natl. Acad. Sci. U. S. A., 99, 11934, 10.1073/pnas.182234399
Rothman, 2000, An open-label study of a functional opioid kappa antagonist in the treatment of opioid dependence, J. Subst. Abuse. Treat., 18, 277, 10.1016/S0740-5472(99)00074-4
Rubinstein, 1996, Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis, Proc. Natl. Acad. Sci. U. S. A., 93, 3995, 10.1073/pnas.93.9.3995
Seizinger, 1981, Evidence for the occurrence of the opioid octapeptide dynorphin-(1-8) in the neurointermediate pituitary of rats, Biochem. Biophys. Res. Common., 102, 197, 10.1016/0006-291X(81)91507-2
Shaham, 1997, Corticotropin-releasing factor, but not corticosterone, is involved in stress-induced relapse to heroin-seeking in rats, J. Neurosci., 17, 2605, 10.1523/JNEUROSCI.17-07-02605.1997
Shaham, 1998, CP-154,526, a selective, non-peptide antagonist of the corticotropin-releasing factor1 receptor attenuates stress-induced relapse to drug seeking in cocaine- and heroin-trained rats, Psychopharmacology (Berl), 137, 184, 10.1007/s002130050608
Shaham, 2000, Stress-induced relapse to heroin and cocaine seeking in rats: a review, Brain Res. Brain Res. Rev., 33, 13, 10.1016/S0165-0173(00)00024-2
Shalev, 2003, The role of corticosterone in food deprivation-induced reinstatement of cocaine seeking in the rat, Psychopharmacology (Berl), 168, 170, 10.1007/s00213-002-1200-5
Shalev, U., Erb, S., Shaham, Y., 2009. Role of CRF and other neuropeptides in stress-induced reinstatement of drug seeking. Brain Res. (July 23, Electronic publication ahead of print).
Shippenberg, 1986, Differential effects of mu and kappa opioid systems on motivational processes, NIDA Res. Monogr., 75, 563
Shippenberg, 1996, Kappa-opioid receptor agonists prevent sensitization to the conditioned rewarding effects of cocaine, J. Pharmacol. Exp. Ther., 276, 545
Shirayama, 2004, Stress increases dynorphin immunoreactivity in limbic brain regions and dynorphin antagonism produces antidepressant-like effects, J. Neurochem., 90, 1258, 10.1111/j.1471-4159.2004.02589.x
Shippenberg, 2007, Dynorphin and the pathophysiology of drug addiction, Pharmacol. Ther., 116, 306, 10.1016/j.pharmthera.2007.06.011
Song, 1992, Stimulation by corticotropin-releasing factor of the release of immunoreactive dynorphin A from mouse spinal cords in vitro, Eur. J. Pharmacol., 222, 27, 10.1016/0014-2999(92)90458-G
Spampinato, 1985, Characterization of dynorphin A-induced antinociception at spinal level, Eur. J. Pharmacol., 110, 21, 10.1016/0014-2999(85)90024-X
Takahashi, 1990, Ultrastructural demonstration of synaptic connections between calcitonin gene-related peptide immunoreactive axons and dynorphin A(1-8) immunoreactive dorsal horn neurons in a rat model of peripheral inflammation and hyperalgesia, Peptides, 11, 1233, 10.1016/0196-9781(90)90157-Z
Tao, 2002, Opioid receptor subtypes differentially modulate serotonin efflux in the rat central nervous system, J. Pharmacol. Exp. Ther., 303, 549, 10.1124/jpet.102.037861
Tao, 2005, mu-Opioids disinhibit and kappa-opioids inhibit serotonin efflux in the dorsal raphe nucleus, Brain Res., 1049, 70, 10.1016/j.brainres.2005.04.076
Tao, 2007, Nociceptin/orphanin FQ decreases serotonin efflux in the rat brain but in contrast to a kappa-opioid has no antagonistic effect on mu-opioid-induced increases in serotonin efflux, Neuroscience, 147, 106, 10.1016/j.neuroscience.2007.02.011
Tomasiewicz, 2008, The kappa-opioid agonist U69,593 blocks cocaine-induced enhancement of brain stimulation reward, Biol. Psychiatry, 64, 982, 10.1016/j.biopsych.2008.05.029
Valdez, 2007, Kappa agonist-induced reinstatement of cocaine seeking in squirrel monkeys: a role for opioid and stress-related mechanisms, J. Pharmacol. Exp. Ther., 323, 525, 10.1124/jpet.107.125484
Vale, 1981, Characterization of a 41-residue ovine hypothalamic peptide that stimulates secretion of corticotropin and beta-endorphin, Science, 213, 1394, 10.1126/science.6267699
Vaughan, 1995, Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor, Nature, 378, 287, 10.1038/378287a0
Veldhuis, 1984, Differential behavioral actions of corticotropin-releasing factor (CRF), Pharmacol. Biochem. Behav., 21, 707, 10.1016/S0091-3057(84)80007-6
Volkow, 2004, Drug addiction: the neurobiology of behaviour gone awry, Nat. Rev. Neurosci., 5, 963, 10.1038/nrn1539
Wagner, 1993, Endogenous dynorphins inhibit excitatory neurotransmission and block LTP induction in the hippocampus, Nature, 363, 451, 10.1038/363451a0
Walker, 2008, Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence, Neuropsychopharmacology, 33, 643, 10.1038/sj.npp.1301438
Wang, 2005, Cocaine experience establishes control of midbrain glutamate and dopamine by corticotropin-releasing factor: a role in stress-induced relapse to drug seeking, J. Neurosci., 25, 5389, 10.1523/JNEUROSCI.0955-05.2005
Wang, 2005, Comparison of pharmacological activities of three distinct kappa ligands (Salvinorin A, TRK-820 and 3FLB) on kappa opioid receptors in vitro and their antipruritic and antinociceptive activities in vivo, J. Pharmacol. Exp. Ther., 312, 220, 10.1124/jpet.104.073668
Watkins, 1992, Kappa opiate receptors mediate tail-shock induced antinociception at spinal levels, Brain. Res., 582, 1, 10.1016/0006-8993(92)90310-6
Weber, 1981, Colocalization of alpha-neo-dynorphin and dynorphin immunoreactivity in hypothalamic neurons, Biochem. Biophys. Res. Commun., 103, 951, 10.1016/0006-291X(81)90902-5
Werling, 1989, Selective opioid antagonist effects on opioid-induced inhibition of release of norepinephrine in guinea pig cortex, Neuropharmacology, 28, 103, 10.1016/0028-3908(89)90044-0
Werling, 1998, Kappa receptor regulation of dopamine release from striatum and cortex of rats and guinea pigs, J. Pharmacol. Exp. Ther., 246, 282
Wittmann, 2009, Prodynorphin-derived peptides are critical modulators of anxiety and regulate neurochemistry and corticosterone, Neuropsychopharmacology, 34, 775, 10.1038/npp.2008.142
Wise, 2002, Brain reward circuitry: insights from unsensed incentives, Neuron, 36, 229, 10.1016/S0896-6273(02)00965-0