B Cell Immunosenescence

Annual Review of Cell and Developmental Biology - Tập 36 Số 1 - Trang 551-574 - 2020
Daniela Frasca1,2,3, Alain Diaz1, Maria Romero1, Denisse García1, Bonnie B. Blomberg1,3
1Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
2Miami Integrative Metabolomics Research Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
3Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, Florida 33136, USA

Tóm tắt

Innate and adaptive immune responses decline with age, leading to greater susceptibility to infectious diseases and reduced responses to vaccines. Diseases are more severe in old than in young individuals and have a greater impact on health outcomes such as morbidity, disability, and mortality. Aging is characterized by increased low-grade chronic inflammation, so-called inflammaging, that represents a link between changes in immune cells and a number of diseases and syndromes typical of old age. In this review we summarize current knowledge on age-associated changes in immune cells with special emphasis on B cells, which are more inflammatory and less responsive to infections and vaccines in the elderly. We highlight recent findings on factors and pathways contributing to inflammaging and how these lead to dysfunctional immune responses. We summarize recent published studies showing that adipose tissue, which increases in size with aging, contributes to inflammaging and dysregulated B cell function.

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Annual Review of Cell and Developmental Biology

Tập 36 Số 1

551-574

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