Addiction and the Brain Antireward System

Annual Review of Psychology - Tập 59 Số 1 - Trang 29-53 - 2008
George F. Koob1, Michel Le Moal2
1Committee on the Neurobiology of Addictive Disorders, The Scripps Research Institute, La Jolla, California 92037, USA. [email protected]
2Institut François Magendie, Institut National de la Santé et de la Recherche Médicale, Unité 862, Université Victor Segalen Bordeaux 2, Bordeaux 33076, France;

Tóm tắt

A neurobiological model of the brain emotional systems has been proposed to explain the persistent changes in motivation that are associated with vulnerability to relapse in addiction, and this model may generalize to other psychopathology associated with dysregulated motivational systems. In this framework, addiction is conceptualized as a cycle of decreased function of brain reward systems and recruitment of antireward systems that progressively worsen, resulting in the compulsive use of drugs. Counteradaptive processes, such as opponent process, that are part of the normal homeostatic limitation of reward function fail to return within the normal homeostatic range and are hypothesized to repeatedly drive the allostatic state. Excessive drug taking thus results in not only the short-term amelioration of the reward deficit but also suppression of the antireward system. However, in the long term, there is worsening of the underlying neurochemical dysregulations that ultimately form an allostatic state (decreased dopamine and opioid peptide function, increased corticotropin-releasing factor activity). This allostatic state is hypothesized to be reflected in a chronic deviation of reward set point that is fueled not only by dysregulation of reward circuits per se but also by recruitment of brain and hormonal stress responses. Vulnerability to addiction may involve genetic comorbidity and developmental factors at the molecular, cellular, or neurocircuitry levels that sensitize the brain antireward systems.

Từ khóa


Tài liệu tham khảo

10.1038/nn872

10.1126/science.282.5387.298

10.1016/S0893-133X(99)00133-5

Alheid GF, 1995, The Rat Nervous System, 495

Am. Psychiatric Assoc. (APA), 1994, Diagnostic and Statistical Manual of Mental Disorders, 4

10.1037//1064-1297.2.3.244

10.1111/j.1749-6632.1999.tb09284.x

10.1007/BF02244208

Baumeister RF, 1994, Losing Control: How and Why People Fail at Self-Regulation

10.1016/0091-3057(92)90438-L

10.1152/jn.1995.73.2.568

10.1523/JNEUROSCI.22-07-02977.2002

Carboni E, 2003, Methods Mol. Med., 79, 481

10.1111/j.1530-0277.1998.tb03883.x

10.1037/0278-6133.9.6.701

10.1007/BF00426372

10.1523/JNEUROSCI.4119-05.2005

10.1097/00008571-199606000-00004

10.1146/annurev.psych.53.100901.135142

10.1111/j.1369-1600.2006.00038.x

10.1016/0006-8993(92)91383-P

10.1126/science.1099020

10.2165/00023210-200519060-00004

10.1016/S0166-4328(02)00286-3

10.1523/JNEUROSCI.22-09-03312.2002

10.1523/JNEUROSCI.3096-06.2006

10.1054/npep.2002.0900

George O, 2007, Proc. Natl. Acad. Sci. USA

10.1037/10341-000

10.1037/10107-000

10.1016/S0899-3289(99)80131-X

10.1001/archpsyc.61.11.1107

10.1001/archpsyc.61.8.807

10.1001/archpsyc.61.4.361

Greenwell TN, Funk CK, Cottone P, Richardson HN, Chen SA, et al. 2007. Corticotropin-releasing factor-1 receptor antagonists decrease heroin self-administration in long- but not short-access rats. Manuscr. submitted

10.1007/s002130050685

10.1146/annurev.psych.58.110405.085605

10.1007/978-1-4757-0145-6_1

10.1046/j.1360-0443.2001.967102312.x

10.15288/jsa.2003.64.23

10.1196/annals.1300.009

10.1523/JNEUROSCI.0740-06.2006

10.1176/ajp.142.11.1259

Khantzian EJ, 1990, Recent Dev. Alcohol, 8, 255

10.3109/10673229709030550

10.1007/s00213-006-0353-z

10.1016/0165-6147(92)90060-J

10.1016/S0006-3223(99)00164-X

Koob GF, 2000, Addiction, 95, s73–81

10.1097/01.ALC.0000057122.36127.C2

Koob GF, 2003, Neuro-Psychoanal., 5, 35

Koob GF, 2004, Nebr. Symp. Motiv., 50, 1

10.1126/science.2903550

10.1016/S0006-8993(99)01991-5

10.1126/science.278.5335.52

10.1016/S0893-133X(00)00195-0

10.1017/CBO9781316257081.008

10.1038/nn1105-1442

Koob GF, 2006, Neurobiology of Addiction.

Kornetsky C, 1990, Mod. Methods Pharmacol., 6, 211

10.1016/S0376-8716(98)00064-7

10.1038/sj.mp.4001197

10.1016/j.cpr.2005.11.008

10.1523/JNEUROSCI.08-07-02517.1988

10.1016/j.biopsych.2005.11.009

Le Moal M, 1995, Psychopharmacology: The Fourth Generation of Progress, 283

10.1038/nrn1604

10.1037/1064-1297.14.1.34

10.1016/S0893-133X(97)00113-9

10.1007/BF02244907

10.1111/j.1749-6632.1998.tb09546.x

10.1016/S0893-133X(99)00129-3

10.1523/JNEUROSCI.21-21-08655.2001

10.1146/annurev.neuro.24.1.1161

Meaney MJ, 2005, Dialogues Clin. Neurosci., 7, 103, 10.31887/DCNS.2005.7.2/mmeaney

10.1002/aja.1001650404

10.1016/S0306-4603(98)00076-8

10.1523/JNEUROSCI.15-08-05439.1995

Natl. Inst. Alcohol Abuse Alcohol. 2004. NIAAA council approves definition of binge drinking. NIAAA Newsl.No. 3

10.1038/35053570

10.1038/nn1578

10.1016/j.pbb.2007.01.004

10.1016/S0091-3057(01)00748-1

10.1007/BF00427441

10.1016/j.neuron.2005.09.025

10.1146/annurev.pa.36.040196.002043

10.1016/S0165-6147(97)01115-2

10.1037/0033-295X.98.3.390

10.1124/mi.2.6.392

10.1016/0006-8993(93)91352-S

10.1016/0006-8993(93)90004-7

10.1523/JNEUROSCI.3004-04.2004

10.1016/S0893-133X(99)00167-0

10.1111/j.1530-0277.2002.tb02607.x

10.1111/j.1469-7610.2005.01557.x

10.1111/j.1530-0277.1986.tb05120.x

10.1038/35016630

10.1111/j.1749-6632.2003.tb07089.x

10.1016/S0165-0173(00)00024-2

10.1007/s00213-002-1224-x

10.1124/pr.54.1.1

10.1523/JNEUROSCI.22-09-03663.2002

Shippenberg TS, 2002, Neuropsychopharmacology: The Fifth Generation of Progress, 1381

10.1037/h0077058

10.1146/annurev.psych.58.110405.085705

10.1037//0003-066X.35.8.691

10.1037/h0036128

Specio SE, Wee S, O’Dell LE, Boutrel B, Zorrilla EP, Koob GF. 2007. CRF1 receptor antagonists attenuate escalated cocaine self-administration in rats. Manuscr. submitted

Sterling P, 1988, Handbook of Life Stress, Cognition and Health, 629

Substance Abuse Ment. Health Serv. Adm. (SAMHSA). 2004. Overview of Findings from the 2003 National Survey on Drug Use and Health(Off. Appl. Stud., NHSDA Ser. H-21, DHHS Publ. No. SMA 03–3774). Rockville, MD: SAMHSA

10.1002/hbm.20344

Tiffany ST, 2000, Addiction, 95, S177–87

10.1001/archpsyc.61.3.223

10.1038/35079077

10.1016/j.pbb.2004.09.020

10.1111/j.1530-0277.2002.tb02448.x

10.1046/j.1460-9568.1999.00705.x

10.1126/science.1098975

10.1172/JCI200318533

10.1523/JNEUROSCI.22-21-09595.2002

10.1517/14728222.6.5.601

10.1038/nn1276

10.1111/j.1749-6632.2001.tb03556.x

10.1016/0006-8993(92)91327-B

10.1038/sj.npp.1301295

10.1517/13543784.13.7.799

Thông tin
Thông tin xuất bản

Annual Review of Psychology

Tập 59 Số 1

29-53

Thông tin tác giả