Synthesis of 1,3- and 1,2,3-functionalized pyrroles via Ir(I)-catalyzed vinylation of allyl alcohols

Chemistry of Heterocyclic Compounds - Tập 53 - Trang 526-531 - 2017
David Alavez-Rosas1, Mauricio Maldonado-Domínguez1, Oscar González-Antonio1, Margarita Romero-Ávila1, José Méndez-Stivalet1, Blas Flores-Pérez1
1School of Chemistry, National Autonomous University of Mexico, México, México

Tóm tắt

An efficient method for the preparation of 1,3-disubstituted and 1,2,3-trisubstituted pyrroles was developed through a sequence involving O-vinylation of allyl alcohols followed by Claisen rearrangement and further ozonolysis, concurring in a Paal–Knorr reaction with primary amines. Hg(II) and Ir(I) catalysts and different vinylating reagents were tested. The best results were consistently obtained with the [Ir(cod)Cl]2–vinyl acetate system. The featured methodology gives access to functionalized pyrroles in overall good yields, whose chemical architecture may awake interest for assorted applications.

Tài liệu tham khảo

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