The organization of the human cerebellum estimated by intrinsic functional connectivity

Journal of Neurophysiology - Tập 106 Số 5 - Trang 2322-2345 - 2011
Randy L. Buckner1,2,3,4, Fenna M. Krienen1,2, Aurora Castellanos2,4, Julio C Diaz5,4, B.T. Thomas Yeo1,2
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, Massachusetts; and
2Center for Brain Science, Department of Psychology, Harvard University, Cambridge;
3Department of Psychiatry, Massachusetts General Hospital, Boston
4Howard Hughes Medical Institute, Cambridge;
5Department of Biology, University of Miami, Miami, Florida

Tóm tắt

The cerebral cortex communicates with the cerebellum via polysynaptic circuits. Separate regions of the cerebellum are connected to distinct cerebral areas, forming a complex topography. In this study we explored the organization of cerebrocerebellar circuits in the human using resting-state functional connectivity MRI (fcMRI). Data from 1,000 subjects were registered using nonlinear deformation of the cerebellum in combination with surface-based alignment of the cerebral cortex. The foot, hand, and tongue representations were localized in subjects performing movements. fcMRI maps derived from seed regions placed in different parts of the motor body representation yielded the expected inverted map of somatomotor topography in the anterior lobe and the upright map in the posterior lobe. Next, we mapped the complete topography of the cerebellum by estimating the principal cerebral target for each point in the cerebellum in a discovery sample of 500 subjects and replicated the topography in 500 independent subjects. The majority of the human cerebellum maps to association areas. Quantitative analysis of 17 distinct cerebral networks revealed that the extent of the cerebellum dedicated to each network is proportional to the network's extent in the cerebrum with a few exceptions, including primary visual cortex, which is not represented in the cerebellum. Like somatomotor representations, cerebellar regions linked to association cortex have separate anterior and posterior representations that are oriented as mirror images of one another. The orderly topography of the representations suggests that the cerebellum possesses at least two large, homotopic maps of the full cerebrum and possibly a smaller third map.

Từ khóa


Tài liệu tham khảo

10.1093/brain/66.4.289

10.1016/j.neuroimage.2005.06.013

10.1006/nimg.1999.0516

10.1016/j.neuron.2010.02.005

10.1016/j.neuroimage.2009.10.045

10.1080/14734220701286195

10.1016/j.neuroimage.2006.02.048

10.1002/mrm.1910340409

10.1073/pnas.0911855107

10.1093/brain/101.2.251

10.1073/pnas.1005987107

10.1196/annals.1440.011

Cole DM, 2010, Front Syst Neurosci, 4, 8

10.1152/jn.1964.27.3.366

10.1006/nimg.1998.0395

10.1016/S1364-6613(98)01211-X

10.1093/cercor/bhn041

10.1098/rstb.2001.0913

10.1016/j.neuroimage.2009.01.045

10.1073/pnas.0704320104

10.1016/j.cortex.2009.09.009

10.1523/JNEUROSCI.15-09-05999.1995

10.1109/NSSMIC.1993.373602

10.1146/annurev.ph.31.030169.002315

10.1109/42.906426

10.1093/cercor/bhm225

10.1016/S0896-6273(02)00569-X

10.1016/j.neuroimage.2004.07.016

10.1006/nimg.1998.0396

10.1002/(SICI)1097-0193(1999)8:4<272::AID-HBM10>3.0.CO;2-4

10.1016/j.neuroimage.2010.07.033

10.1038/nrn2201

10.1152/jn.90777.2008

10.1002/hbm.460030303

10.1038/382805a0

10.1002/cne.902350306

10.1016/j.cub.2007.08.009

10.1146/annurev.ne.11.030188.001033

10.1006/nimg.2001.0858

10.1016/j.neuroimage.2009.06.060

10.1002/hbm.1025

10.1523/JNEUROSCI.1868-09.2009

10.1073/pnas.1001229107

10.1093/brain/62.1.1

Ito M, 1984, The Cerebellum and Neural Control

10.1006/nimg.2002.1132

10.1152/jn.00077.2008

10.1523/JNEUROSCI.23-23-08432.2003

10.1098/rstb.1971.0106

10.1093/cercor/bhp135

10.1073/pnas.89.12.5675

10.1002/hbm.20136

Larsell O, 1970, The Comparative Anatomy and Histology of the Cerebellum From Monotremes Through Apes

10.1037/0735-7044.100.4.443

10.1007/s11065-010-9140-z

Lu J, J Neurosci

10.1093/cercor/bhj181

10.1038/nrn1347

10.1162/jocn.2009.21407

10.1162/jocn.2007.19.9.1498

10.1016/j.neuroimage.2007.05.019

10.1016/j.cortex.2009.08.017

10.1126/science.7939688

10.1523/JNEUROSCI.21-02-00700.2001

10.1523/JNEUROSCI.0220-09.2009

10.1016/j.neuroimage.2008.09.036

10.1073/pnas.89.13.5951

10.1093/cercor/bhp157

10.1523/JNEUROSCI.2742-07.2008

10.1016/S0006-8993(71)80001-X

10.1162/jocn.1989.1.2.153

Preuss TM, 2004, The Cognitive Neurosciences III, 5

10.1073/pnas.98.2.676

10.1089/brain.2011.0019

10.1016/j.neuroimage.2008.11.030

10.1152/jn.01117.2009

10.1006/nimg.1999.0459

Schmahmann JD, 2000, MRI Atlas of the Human Cerebellum

10.1016/S0074-7742(08)60346-3

10.1523/JNEUROSCI.17-01-00438.1997

10.1002/cne.20286

10.1002/ana.20060

10.1080/14734220701490995

10.1523/JNEUROSCI.5587-06.2007

10.1016/j.neuroimage.2004.03.032

10.1109/TMI.2006.887364

10.1523/JNEUROSCI.05-03-00776.1985

10.1159/000123774

10.1016/j.neuroimage.2004.07.051

10.1152/jn.1952.15.1.27

10.1152/jn.1944.7.6.331

10.1016/j.neuroimage.2007.03.009

10.1016/j.neuroimage.2008.08.039

10.1146/annurev.neuro.31.060407.125606

10.1016/0166-4328(85)90067-1

10.1080/14734220701496448

10.1016/j.neuroimage.2005.03.035

10.1016/j.neuroimage.2007.12.025

10.1152/jn.00783.2009

10.1016/j.neuroimage.2005.06.058

10.1111/j.1749-6632.2002.tb07588.x

10.1016/j.neuron.2007.10.015

10.1523/JNEUROSCI.02-03-00265.1982

10.1152/jn.00048.2006

10.1016/j.neuron.2007.10.012

10.1152/jn.00106.2011

10.1007/s00429-005-0064-y

10.1016/j.neuroimage.2003.11.025

10.1152/jn.00338.2011

10.1109/TMI.2010.2049497

10.1152/jn.90463.2008

Thông tin
Thông tin xuất bản

Journal of Neurophysiology

Tập 106 Số 5

2322-2345

Thông tin tác giả