Toxic Potential of Materials at the Nanolevel

American Association for the Advancement of Science (AAAS) - Tập 311 Số 5761 - Trang 622-627 - 2006
André E. Nel1,2,3, Tian Xia1,2,3, Lutz Mädler1,2,3, Ning Li1,2,3
1California NANOSystems Institute, University of California, Los Angeles, CA 90095, USA.
2Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, CA 90095, USA
3Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA

Tóm tắt

Nanomaterials are engineered structures with at least one dimension of 100 nanometers or less. These materials are increasingly being used for commercial purposes such as fillers, opacifiers, catalysts, semiconductors, cosmetics, microelectronics, and drug carriers. Materials in this size range may approach the length scale at which some specific physical or chemical interactions with their environment can occur. As a result, their properties differ substantially from those bulk materials of the same composition, allowing them to perform exceptional feats of conductivity, reactivity, and optical sensitivity. Possible undesirable results of these capabilities are harmful interactions with biological systems and the environment, with the potential to generate toxicity. The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.

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We apologize for the many seminal contributions that have not been cited for lack of space. This work was supported by U.S. Public Health Service grants RO-1 ES10553 RO1 ES12053 RO1 ES013432 and PO1 AI50495 (UCLA Asthma and Immunology Disease Center) and by the U.S. EPA (STAR grant to the Southern California Particle Center and Supersite). This manuscript has not been subjected to the EPA's peer and policy review. L.M. was supported by the Parson's chair at UCLA.

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American Association for the Advancement of Science (AAAS)

Tập 311 Số 5761

622-627

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