Omega-3 Fatty Acids EPA and DHA: Health Benefits Throughout Life

Su, 2008, Omega-3 fatty acids for major depressive disorder during pregnancy: results from a randomized, double-blind, placebo-controlled trial, J Clin Psychiatry, 69, 644, 10.4088/JCP.v69n0418 Lazzarin, 2009, Low-dose aspirin and omega-3 fatty acids improve uterine artery blood flow velocity in women with recurrent miscarriage due to impaired uterine perfusion, Fertil Steril, 92, 296, 10.1016/j.fertnstert.2008.05.045 Smith, 2011, Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial, Am J Clin Nutr, 93, 402, 10.3945/ajcn.110.005611 Conquer, 2000, Fatty acid analysis of blood plasma of patients with Alzheimer's disease, other types of dementia, and cognitive impairment, Lipids, 35, 1305, 10.1007/s11745-000-0646-3 Dunstan, 2007, The effects of fish oil supplementation in pregnancy on breast milk fatty acid composition over the course of lactation: a randomized controlled trial, Pediatr Res, 62, 689, 10.1203/PDR.0b013e318159a93a Krauss-Etschmann, 2007, Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: a European randomized multicenter trial, Am J Clin Nutr, 85, 1392, 10.1093/ajcn/85.5.1392 Serhan, 2008, Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators, Nat Rev Immunol, 8, 349, 10.1038/nri2294 Neff, 2011, Algal docosahexaenoic acid affects plasma lipoprotein particle size distribution in overweight and obese adults, J Nutr, 141, 207, 10.3945/jn.110.130021 Chiu, 2008, The effects of omega-3 fatty acids monotherapy in Alzheimer's disease and mild cognitive impairment: a preliminary randomized double-blind placebo-controlled study, Prog Neuropsychopharmacol Biol Psychiatry, 32, 1538, 10.1016/j.pnpbp.2008.05.015 Goyens, 2005, Compartmental modeling to quantify alpha-linolenic acid conversion after longer term intake of multiple tracer boluses, J Lipid Res, 46, 1474, 10.1194/jlr.M400514-JLR200 Hussein, 2005, Long-chain conversion of [13C]linoleic acid and alpha-linolenic acid in response to marked changes in their dietary intake in men, J Lipid Res, 46, 269, 10.1194/jlr.M400225-JLR200 2010 Dangardt, 2010, Omega-3 fatty acid supplementation improves vascular function and reduces inflammation in obese adolescents, Atherosclerosis, 212, 580, 10.1016/j.atherosclerosis.2010.06.046 Leaf, 2009, The effect of lean fish consumption on triglyceride levels, Phys Sportsmed, 37, 37, 10.3810/PSM.2009.04.1681 Mann, 2010, Effects of seal oil and tuna-fish oil on platelet parameters and plasma lipid levels in healthy subjects, Lipids, 45, 669, 10.1007/s11745-010-3450-z Saito, 2008, Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS), Atherosclerosis, 200, 135, 10.1016/j.atherosclerosis.2008.06.003 Ramakrishnan, 2010, Effects of docosahexaenoic acid supplementation during pregnancy on gestational age and size at birth: randomized, double-blind, placebo-controlled trial in Mexico, Food Nutr Bull, 31, S108, 10.1177/15648265100312S203 Helland, 2008, Effect of supplementing pregnant and lactating mothers with n-3 very-long-chain fatty acids on children's IQ and body mass index at 7 years of age, Pediatrics, 122, e472, 10.1542/peds.2007-2762 Dunstan, 2008, Cognitive assessment of children at age 2(1/2) years after maternal fish oil supplementation in pregnancy: a randomised controlled trial, Arch Dis Child Fetal Neonatal Ed, 93, F45, 10.1136/adc.2006.099085 Judge, 2007, Maternal consumption of a docosahexaenoic acid-containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo, Am J Clin Nutr, 85, 1572, 10.1093/ajcn/85.6.1572 Olsen, 2008, Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial, Am J Clin Nutr, 88, 167, 10.1093/ajcn/88.1.167 Harper, 2010, Omega-3 fatty acid supplementation to prevent recurrent preterm birth: a randomized controlled trial, Obstet Gynecol, 115, 234, 10.1097/AOG.0b013e3181cbd60e Olsen, 2007, Duration of pregnancy in relation to fish oil supplementation and habitual fish intake: a randomised clinical trial with fish oil, Eur J Clin Nutr, 61, 976, 10.1038/sj.ejcn.1602609 Roman, 2006, Omega-3 fatty acids and decidual cell prostaglandin production in response to the inflammatory cytokine IL-1beta, Am J Obstet Gynecol, 195, 1693, 10.1016/j.ajog.2006.04.009 Makrides, 2010, Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial, JAMA, 304, 1675, 10.1001/jama.2010.1507 Krauss-Etschmann, 2008, Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women, J Allergy Clin Immunol, 121, 464, 10.1016/j.jaci.2007.09.018 Furuhjelm, 2009, Fish oil supplementation in pregnancy and lactation may decrease the risk of infant allergy, Acta Paediatr, 98, 1461, 10.1111/j.1651-2227.2009.01355.x Kelley, 2009, DHA supplementation decreases serum C-reactive protein and other markers of inflammation in hypertriglyceridemic men, J Nutr, 139, 495, 10.3945/jn.108.100354 Schubert, 2007, Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults, Nutrition, 23, 724, 10.1016/j.nut.2007.06.012 Bloomer, 2009, Effect of eicosapentaenoic and docosahexaenoic acid on resting and exercise-induced inflammatory and oxidative stress biomarkers: a randomized, placebo controlled, cross-over study, Lipids Health Dis, 8, 36, 10.1186/1476-511X-8-36 Bouwens, 2009, Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells, Am J Clin Nutr, 90, 415, 10.3945/ajcn.2009.27680 Micallef, 2009, Anti-inflammatory and cardioprotective effects of n-3 polyunsaturated fatty acids and plant sterols in hyperlipidemic individuals, Atherosclerosis, 204, 476, 10.1016/j.atherosclerosis.2008.09.020 Ebrahimi, 2009, Omega-3 fatty acid supplements improve the cardiovascular risk profile of subjects with metabolic syndrome, including markers of inflammation and auto-immunity, Acta Cardiol, 64, 321, 10.2143/AC.64.3.2038016 Kris-Etherton, 2002, Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease, Circulation, 106, 2747, 10.1161/01.CIR.0000038493.65177.94 Tavazzi, 2008, Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): a randomised, double-blind, placebo-controlled trial, Lancet, 372, 1223, 10.1016/S0140-6736(08)61239-8 Marchioli, 2002, Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevenzione, Circulation, 105, 1897, 10.1161/01.CIR.0000014682.14181.F2 Yokoyama, 2007, Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis, Lancet, 369, 1090, 10.1016/S0140-6736(07)60527-3 Oikawa, 2009, Suppressive effect of EPA on the incidence of coronary events in hypercholesterolemia with impaired glucose metabolism: Sub-analysis of the Japan EPA Lipid Intervention Study (JELIS), Atherosclerosis, 206, 535, 10.1016/j.atherosclerosis.2009.03.029 Kromhout, 2010, n-3 fatty acids and cardiovascular events after myocardial infarction, N Engl J Med, 363, 2015, 10.1056/NEJMoa1003603 Rauch, 2010, OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction, Circulation, 122, 2152, 10.1161/CIRCULATIONAHA.110.948562 Dawczynski, 2010, n-3 LC-PUFA-enriched dairy products are able to reduce cardiovascular risk factors: a double-blind, cross-over study, Clin Nutr, 29, 592, 10.1016/j.clnu.2010.02.008 Cawood, 2010, Eicosapentaenoic acid (EPA) from highly concentrated n-3 fatty acid ethyl esters is incorporated into advanced atherosclerotic plaques and higher plaque EPA is associated with decreased plaque inflammation and increased stability, Atherosclerosis, 212, 252, 10.1016/j.atherosclerosis.2010.05.022 Schiano, 2008, Omega-3 polyunsaturated fatty acid in peripheral arterial disease: effect on lipid pattern, disease severity, inflammation profile, and endothelial function, Clin Nutr, 27, 241, 10.1016/j.clnu.2007.11.007 Ishikawa, 2010, Preventive effects of eicosapentaenoic acid on coronary artery disease in patients with peripheral artery disease, Circ J, 74, 1451, 10.1253/circj.CJ-09-0520 Lev, 2010, Treatment of aspirin-resistant patients with omega-3 fatty acids versus aspirin dose escalation, J Am Coll Cardiol, 55, 114, 10.1016/j.jacc.2009.08.039 Gajos, 2010, J Am Coll Cardiol, 55, 1671, 10.1016/j.jacc.2009.11.080 Freund-Levi, 2006, Omega-3 fatty acid treatment in 174 patients with mild to moderate Alzheimer disease: OmegAD study: a randomized double-blind trial, Arch Neurol, 63, 1402, 10.1001/archneur.63.10.1402 Gillette-Guyonnet, 2009, Commentary on “A roadmap for the prevention of dementia II. Leon Thal Symposium 2008.” The Multidomain Alzheimer Preventive Trial (MAPT): a new approach to the prevention of Alzheimer's disease, Alzheimers Dement, 5, 114, 10.1016/j.jalz.2009.01.008 Tully, 2003, Low serum cholesteryl ester-docosahexaenoic acid levels in Alzheimer's disease: a case-control study, Br J Nutr, 89, 483, 10.1079/BJN2002804 Gu, 2010, Food combination and Alzheimer disease risk: a protective diet, Arch Neurol, 67, 699, 10.1001/archneurol.2010.84 Lim, 2005, A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model, J Neurosci, 25, 3032, 10.1523/JNEUROSCI.4225-04.2005 Freund-Levi, 2009, Effects of omega-3 fatty acids on inflammatory markers in cerebrospinal fluid and plasma in Alzheimer's disease: the OmegAD study, Dement Geriatr Cogn Disord, 27, 481, 10.1159/000218081 Vedin, 2008, Effects of docosahexaenoic acid-rich n-3 fatty acid supplementation on cytokine release from blood mononuclear leukocytes: the OmegAD study, Am J Clin Nutr, 87, 1616, 10.1093/ajcn/87.6.1616 Irving, 2009, Omega-3 fatty acid supplementation effects on weight and appetite in patients with Alzheimer's disease: the omega-3 Alzheimer's disease study, J Am Geriatr Soc, 57, 11, 10.1111/j.1532-5415.2008.02055.x Freund-Levi, 2008, Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms, Int J Geriatr Psychiatry, 23, 161, 10.1002/gps.1857 Quinn, 2010, Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial, JAMA, 304, 1903, 10.1001/jama.2010.1510