Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

American Association for the Advancement of Science (AAAS) - Tập 220 Số 4599 - Trang 868-871 - 1983
Françoise Barré‐Sinoussi1, Jean‐Claude Chermann1, Rawlins Fa1, Elisabeth Menu1, S. Chamaret1, J Gruest1, C Dauguet1, C. Axler-Blin1, F. Vézinet-Brun2, C. Rouzioux2, W Rozenbaum3, L Montagnier1
1Institut Pasteur, Département de Virologie, 75724 Paris Cédex 15
2Hôpital Claude Bernard, Laboratoire Central-Virologie, 75019 Paris
3Hôpital La Pitié-Salpétrière, Département de Santé Publique et Médecine Tropicale, 75013 Paris

Tóm tắt

A retrovirus belonging to the family of recently discovered human T-cell leukemia viruses (HTLV), but clearly distinct from each previous isolate, has been isolated from a Caucasian patient with signs and symptoms that often precede the acquired immune deficiency syndrome (AIDS). This virus is a typical type-C RNA tumor virus, buds from the cell membrane, prefers magnesium for reverse transcriptase activity, and has an internal antigen (p25) similar to HTLV p24. Antibodies from serum of this patient react with proteins from viruses of the HTLV-I subgroup, but type-specific antisera to HTLV-I do not precipitate proteins of the new isolate. The virus from this patient has been transmitted into cord blood lymphocytes, and the virus produced by these cells is similar to the original isolate. From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.

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Tài liệu tham khảo

MORBIDITY AND MORTALITY WEEKLY REPORT 31: 507 (1982).

NEW ENGLAND JOURNAL OF MEDICINE 306: 248 (1982).

BARRESINOUSSI, F, ENHANCEMENT OF RETROVIRUS PRODUCTION BY ANTI-INTERFERON SERUM, ANNALES DE MICROBIOLOGIE 130: 349 (1979).

FANNIN, S, MMWR 31: 305 (1982).

GALLO, R.C., HUMAN RETROVIRUSES AND ADULT T-CELL LEUKEMIA LYMPHOMA, JOURNAL OF THE NATIONAL CANCER INSTITUTE 69: 1209 (1982).

GELMANN E COMMUNICATION.

10.1128/jvi.38.3.906-915.1981

10.1126/science.6981847

10.1073/pnas.76.7.3154

10.1038/227608a0

MARMOR, M, RISK-FACTORS FOR KAPOSIS SARCOMA IN HOMOSEXUAL MEN, LANCET 1: 1083 (1982).

MILDVAN, D, MORBIDITY AND MORTALITY WEEKLY REPORT 31: 249 (1982).

OREILLY, R, MORBIDITY AND MORTALITY WEEKLY REPORT 31: 665 (1982).

10.1073/pnas.77.12.7415

POON, M.C., MORBIDITY AND MORTALITY WEEKLY REPORT 31: 644 (1982).

10.1126/science.6600519

10.1084/jem.154.6.1957

ROZENBAUM, W, MULTIPLE OPPORTUNISTIC INFECTION IN A MALE-HOMOSEXUAL IN FRANCE, LANCET 1: 572 (1982).

10.1016/0002-9343(82)90174-7

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American Association for the Advancement of Science (AAAS)

Tập 220 Số 4599

868-871

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