γ/δ T cell subsets in human aging using the classical α/β T cell model

Journal of Leukocyte Biology - Tập 96 Số 4 - Trang 647-655 - 2014
Anusha Vasudev1, Chaoran Ying1, Shamini Ayyadhury1, Kia Joo Puan1, Anand Kumar Andiappan1, Ma Shwe Zin Nyunt2, Nurhidaya Binte Shadan1, Seri Mustafa1, Ivy Low1, Olaf Rötzschke1, Tamàs Fülöp3, Tze Pin Ng2, Anis Larbi1
1Singapore Immunology Network, Biopolis, Agency for Science Technology and Research, Singapore
2Gerontological Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
3Research Center on Aging, University of Sherbrooke, Faculty of Medicine , Québec, Canada

Tóm tắt

AbstractAging is associated with an increased susceptibility to infections and diseases. It has also been associated with reduced functionality and altered distribution of immune cells, especially T cells. Whereas classical α/β T cells, especially CD8+ T cells, were shown to be highly susceptible to aging, the effects of viral persistent stimulations on the fate of γ/δ T cells are much less documented. Healthy, elderly individuals of Chinese ethnical background were recruited under the aegis of SLAS-II. In this observational study, γ/δ T cell populations were characterized by flow cytometry and compared with the α/β CD4+ and CD8+ T cells in elderly and young controls. In our study, we identified a reduced frequency of γ/δ T cells but not α/β T cells with aging. The classical markers of α/β T cell aging, including CD28, CD27, and CD57, did not prove significant for γ/δ T cells. The extreme range of expression of these markers in γ/δ T cells was responsible for the lack of relationship between γ/δ T cell subsets, CD4/CD8 ratio, and anti-CMV titers that was significant for α/β T cells and, especially, CD8+ T cells. Although markers of aging for γ/δ T cells are not clearly identified, our data collectively suggest that the presence of CD27 γ/δ T cells is associated with markers of α/β T cell aging.

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Journal of Leukocyte Biology

Tập 96 Số 4

647-655

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