Maintenance of Genome Stability in Saccharomyces cerevisiae

American Association for the Advancement of Science (AAAS) - Tập 297 Số 5581 - Trang 552-557 - 2002
Richard D. Kolodner1, Christopher D. Putnam1, Kyungjae Myung1
1Ludwig Institute for Cancer Research, Cancer Center and Department of Medicine, CMME3058, 9500 Gilman Drive, University of California–San Diego School of Medicine, La Jolla, CA 92093, USA.

Tóm tắt

Most human cancer cells show signs of genome instability, ranging from elevated mutation rates to gross chromosomal rearrangements and alterations in chromosome number. Little is known about the molecular mechanisms that generate this instability or how it is suppressed in normal cells. Recent studies of the yeast Saccharomyces cerevisiae have begun to uncover the extensive and redundant pathways that keep the rate of genome rearrangements at very low levels. These studies, which we review here, have implicated more than 50 genes in the suppression of genome instability, including genes that function in S-phase checkpoints, recombination pathways, and telomere maintenance. Human homologs of several of these genes have well-established roles as tumor suppressors, consistent with the hypothesis that the mechanisms preserving genome stability in yeast are the same mechanisms that go awry in cancer.

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Tài liệu tham khảo

Reviewed in

Kolodner R., Genes Dev. 10, 1433 (1996).

Reviewed in

10.1038/25292

Reviewed in

Vessey C. J., Norbury C. J., Hickson I. D., Prog. Nucleic Acid Res. Mol. Biol. 63, 189 (1999).

Reviewed in

Kolodner R. D., Marsischky G. T., Curr. Opin. Genet. Dev. 9, 89 (1999).

W. M. Abdel-Rahman et al. Proc. Natl. Acad. Sci. U.S.A. 98 2538 (2001).

Sattler M., Griffin J. D., Int. J. Hematol. 73, 278 (2001).

Bayani J., Squire J. A., Clin. Genet. 59, 65 (2001).

Deininger P. L., Batzer M. A., Mol. Genet. Metab. 67, 183 (1999).

Sugawara N., Szostak J. W., Proc. Natl. Acad. Sci. U.S.A. 80, 5675 (1983).

Mikus M. D., Petes T. D., Genetics 101, 369 (1982).

Jinks-Robertson S., Petes T. D., Genetics 114, 731 (1986).

Chen C., Kolodner R. D., Nature Genet. 23, 81 (1999).

Chen C., Umezu K., Kolodner R. D., Mol. Cell 2, 9 (1998).

Myung K., Datta A., Kolodner R. D., Cell 104, 397 (2001).

Myung K., Chen C., Kolodner R. D., Nature 411, 1073 (2001).

Hackett J. A., Feldser D. M., Greider C. W., Cell 106, 275 (2001).

10.1016/0092-8674(94)90179-1

Bosco G., Haber J. E., Genetics 150, 1037 (1998).

Diede S. J., Gottschling D. E., Cell 99, 723 (1999).

10.1093/genetics/156.4.1531

Umezu K., Hiraoka M., Mori M., Maki H., Genetics 160, 97 (2002).

Klein H. L., Genetics 159, 1501 (2001).

Datta A., Adjiri A., New L., Crouse G. F., Jinks-Robertson S., Mol. Cell. Biol. 16, 1085 (1996).

Merker R. J., Klein H. L., Mol. Cell. Biol. 22, 421 (2002).

Keil R. L., McWilliams A. D., Genetics 135, 711 (1993).

Lobachev K. S., Gordenin D. A., Resnick M. A., Cell 108, 183 (2002).

K. S. Lobachev et al. EMBO J. 19 3822 (2000).

Reviewed in M. Foiani et al. Mutat. Res. 451 187 (2000).

Reviewed in

Gardner R. D., Burke D. J., Trends Cell Biol. 10, 154 (2000).

10.1038/27001

K. Shirahige et al. Nature 395 618 (1998).

Marcand S., Brevet V., Mann C., Gilson E., Curr. Biol. 10, 487 (2000).

Paulovich A. G., Toczyski D. P., Hartwell L. H., Cell 88, 315 (1997).

10.1016/S0959-437X(99)00050-7

Paulovich A. G., Margulies R. U., Garvik B. M., Hartwell L. H., Genetics 145, 45 (1997).

Frei C., Gasser S. M., Genes Dev. 14, 81 (2000).

10.1038/35044005

Myung K., Kolodner R. D., Proc. Natl. Acad. Sci. U.S.A. 99, 4500 (2002).

Sidorova J. M., Breeden L. L., Genes Dev. 11, 3032 (1997).

Reviewed in

Cromie G. A., Connelly J. C., Leach D. R., Mol. Cell 8, 1163 (2001).

Reviewed in

Kraus E., Leung W. Y., Haber J. E., Proc. Natl. Acad. Sci. U.S.A. 98, 8255 (2001).

Reviewed in

Kuzminov A., Microbiol. Mol. Biol. Rev. 63, 751 (1999).

Malkova A., Ivanov E. L., Haber J. E., Proc. Natl. Acad. Sci. U.S.A. 93, 7131 (1996).

Signon L., Malkova A., Naylor M. L., Klein H., Haber J. E., Mol. Cell. Biol. 21, 2048 (2001).

Bressan D. A., Baxter B. K., Petrini J. H., Mol. Cell. Biol. 19, 7681 (1999).

10.1093/emboj/17.6.1819

Le S., Moore J. K., Haber J. E., Greider C. W., Genetics 152, 143 (1999).

McClintock B., Proc. Natl. Acad. Sci. U.S.A. 25, 405 (1939).

de Lange T., Oncogene 21, 532 (2002).

Lundblad V., Szostak J. W., Cell 57, 633 (1989).

10.1126/science.7545955

10.1126/science.281.5384.1818

10.1016/0092-8674(93)90234-H

10.1128/MCB.19.12.8083

Chen Q., Ijpma A., Greider C. W., Mol. Cell. Biol. 21, 1819 (2001).

Weinert T. A., Kiser G. L., Hartwell L. H., Genes Dev. 8, 652 (1994).

10.1128/MCB.20.12.4393-4404.2000

J. Mallory K. Trujillo P. Sung T. D. Petes unpublished data.

Reviewed in

10.1016/S0959-437X(98)80145-7

10.1126/science.289.5480.771

Marsischky G. T., Filosi N., Kane M. F., Kolodner R., Genes Dev. 10, 407 (1996).

Sia E. A., Kokoska R. J., Dominska M., Greenwell P., Petes T. D., Mol. Cell. Biol. 17, 2851 (1997).

R. J. Kokoska et al. Mol. Cell. Biol. 18 2779 (1998).

Tishkoff D. X., Filosi N., Gaida G. M., Kolodner R. D., Cell 88, 253 (1997).

Huang M. E., Rio A. G., Galibert M. D., Galibert F., Genetics 160, 1409 (2002).

Lopes J., Debrauwere H., Buard J., Nicolas A., EMBO J. 21, 3201 (2002).

Leach D. R., Stahl F. W., Nature 305, 448 (1983).

J. E. Stenger et al. Genome Res. 11 12 (2001).

Tran H. T., Gordenin D. A., Resnick M. A., Genetics 143, 1579 (1996).

Watanabe K., Morishita J., Umezu K., Shirahige K., Maki H., Euk. Cell 1, 200 (2002).

Harfe B. D., Jinks-Robertson S., Annu. Rev. Genet. 34, 359 (2000).

Myung K., Datta A., Chen C., Kolodner R. D., Nature Genet. 27, 113 (2001).

Rizki A., Lundblad V., Nature 411, 713 (2001).

10.1016/S0092-8674(00)80683-2

Zou H., Rothstein R., Cell 90, 87 (1997).

A. Shoemaker C. D. Putnam R. D. Kolodner unpublished data.

M. Lopes et al. Nature 412 557 (2001).

Lengronne A., Schwob E., Mol. Cell 9, 1067 (2002).

Reviewed in

Michel B., Trends Biochem. Sci. 25, 173 (2000).

10.1016/S0092-8674(00)81772-9

Marians K. J., Curr. Opin. Genet. Dev. 10, 151 (2000).

10.1126/science.286.5448.2339

Gangloff S., Soustelle C., Fabre F., Nature Genet. 25, 192 (2000).

Kaliraman V., Mullen J. R., Fricke W. M., Baastin-Shanower S. A., Brill S. J., Genes Dev. 15, 2730 (2001).

M. N. Boddy et al. Cell 107 537 (2001).

H. M. Padilla-Nash et al. Genes Chromosomes Cancer 25 53 (1999).

K. Savitsky et al. Science 268 1749 (1995).

D. W. Bell et al. Science 286 2528 (1999).

N. A. Ellis et al. Cell 83 655 (1995).

J. P. Carney et al. Cell 93 477 (1998).

S. Kitao et al. Nature Genet. 22 82 (1999).

G. S. Stewart et al. Cell 99 577 (1999).

C.-E. Yu et al. Science 272 258 (1996).

R. Varon et al. Cell 93 467 (1998).

10.1038/85798

T. Taniguchi et al. Cell 109 459 (2002).

10.1126/science.1073834

; published online 13 June 2002 (10.1126/science. 1073834).

We thank K. Arden R. Fishel W.-D. Heyer and V. Lundblad for comments on the manuscript and members of our laboratory for numerous helpful discussions. Supported by grants from the National Institutes of Health and the Cancer Research Fund of the Damon Runyon–Walter Winchell Foundation. We apologize to researchers whose studies we could not discuss or cite because of space limitations.

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American Association for the Advancement of Science (AAAS)

Tập 297 Số 5581

552-557

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