Adipose tissues as an ancestral immune organ: Site‐specific change in obesity

FEBS Letters - Tập 579 - Trang 3487-3492 - 2005
S. Caspar-Bauguil1,2, B. Cousin1, A. Galinier1,2, C. Segafredo2, M. Nibbelink1, M. André1, L. Casteilla1, L. Pénicaud1
1UMR 5018 CNRS-UPS, IFR 31, CHU Rangueil, TSA 50032, 31059 Toulouse Cedex 9, France
2Groupe de Recherche et d’Etude en Nutrition (GREEN), Laboratoire de Biochimie Générale et Nutritionnelle, Place du Docteur Baylac, CHU Purpan, TSA 40031, 31059 Toulouse Cedex 9, France

Tóm tắt

Close relationships have been demonstrated between adipose tissue and the inflammatory/immune system. Furthermore, obesity is increasingly considered as a state of chronic inflammation. Cytofluorometric analysis reveals the presence of significant levels of lymphocytes in the stroma‐vascular fraction of white adipose tissues. In epididymal (EPI) fat, lymphocytes display an “ancestral” immune system phenotype (up to 70% of natural killer (NK), γδ+ T and NKT cells among all lymphocytes) whereas the inguinal (ING) immune system presents more adaptive characteristics (high levels of αβ+ T and B cells). The percentage of NK cells in EPI fat was decreased in obese mice fed with a high‐fat diet, whereas γδ positive cells were significantly increased in ING fat. These data support the notion that adipose tissue may elaborate immunological mechanisms to regulate its functions which might be altered in obesity.

Tài liệu tham khảo

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FEBS Letters

Tập 579

3487-3492

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