Motion‐compensated gradient waveforms for tensor‐valued diffusion encoding by constrained numerical optimization

Magnetic Resonance in Medicine - Tập 85 Số 4 - Trang 2117-2126 - 2021
Filip Szczepankiewicz1,2,3, Jens Sjölund4,5, Erica Dall’Armellina6, Sven Plein6, Jürgen E. Schneider6, Irvin Teh6, Carl‐Fredrik Westin2,3
1Diagnostic Radiology, Clinical Sciences Lund, Lund University, Lund, Sweden
2Harvard Medical School Boston Massachusetts USA
3Radiology, Brigham and Women's Hospital, Boston, Massachusetts, USA
4Department of Information Technology, Uppsala University, Uppsala, Sweden
5Elekta Instrument AB, Stockholm, Sweden
6Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom

Tóm tắt

PurposeDiffusion‐weighted MRI is sensitive to incoherent tissue motion, which may confound the measured signal and subsequent analysis. We propose a “motion‐compensated” gradient waveform design for tensor‐valued diffusion encoding that negates the effects bulk motion and incoherent motion in the ballistic regime.MethodsMotion compensation was achieved by constraining the magnitude of gradient waveform moment vectors. The constraint was incorporated into a numerical optimization framework, along with existing constraints that account for b‐tensor shape, hardware restrictions, and concomitant field gradients. We evaluated the efficacy of encoding and motion compensation in simulations, and we demonstrated the approach by linear and planar b‐tensor encoding in a healthy heart in vivo.ResultsThe optimization framework produced asymmetric motion‐compensated waveforms that yielded b‐tensors of arbitrary shape with improved efficiency compared with previous designs for tensor‐valued encoding, and equivalent efficiency to previous designs for linear (conventional) encoding. Technical feasibility was demonstrated in the heart in vivo, showing vastly improved data quality when using motion compensation. The optimization framework is available online in open source.ConclusionOur gradient waveform design is both more flexible and efficient than previous methods, facilitating tensor‐valued diffusion encoding in tissues in which motion would otherwise confound the signal. The proposed design exploits asymmetric encoding times, a single refocusing pulse or multiple refocusing pulses, and integrates compensation for concomitant gradient effects throughout the imaging volume.

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Magnetic Resonance in Medicine

Tập 85 Số 4

2117-2126

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