Clinical and molecular response to interferon-α therapy in essential thrombocythemia patients with CALR mutations

Blood - Tập 126 - Trang 2585-2591 - 2015
Emmanuelle Verger1, Bruno Cassinat1, Aurélie Chauveau2,3, Christine Dosquet1, Stephane Giraudier4,5, Marie-Hélène Schlageter1, Jean-Christophe Ianotto6, Mohammed A. Yassin7, Nader Al-Dewik8, Serge Carillo9, Eric Legouffe10, Valerie Ugo11,12, Christine Chomienne1,13, Jean-Jacques Kiladjian13,14
1Service de Biologie Cellulaire, Hopital Saint-Louis, Assistance Publique–Hôpitaux de Paris, Paris, France;
2Laboratoire d'Hematologie, Centre Hospitalier Régional Universitaire de Brest, Brest, France;
3Université de Brest, Unité de Formation et de Recherche de medecine, Brest, France;
4Laboratoire d'Hematologie, Hopital Henri Mondor, Assistance Publique–Hôpitaux de Paris, Creteil, France;
5Université Paris 12, Creteil, France;
6Service d'Hematologie Clinique, Institut de Cancérologie, Centre Hospitalier Régional Universitaire de Brest, Brest, France;
7Department of Hematology and Bone Marrow Transplant, National Center for Cancer Care and Research, and
8Qatar Medical Genetic Center, Hamad Medical Corporation, Doha, Qatar;
9Département de Cytologie Clinique, Centre Hospitalier Universitaire de Nimes, Nimes, France;
10Oncogard, Institut de Cancerologie du Gard, Nimes, France;
11Hematologie Biologique, Centre Hospitalier Universitaire Angers, Angers, France;
12Université d'Angers, Unité de Formation et de Recherche de Medecine, Angers, France;
13Université Paris Diderot, Paris, France; and
14Centre d'Investigations Cliniques, Hopital Saint-Louis, Assistance Publique–Hôpitaux de Paris, Paris, France

Tóm tắt

Key Points Pegylated IFNα induces hematologic and molecular remission in CALR-mutated ET patients. The analysis of additional mutations highlights the presence of subclones with variable evolutions during IFNα therapy.

Tài liệu tham khảo

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