Production of omega-3 polyunsaturated fatty acid concentrates: A review

Nuria Rubio-Rodríguez1, Sagrario Beltrán1, Isabel Jaime1, Sara M. de Diego1, María Teresa Sanz1, Jordi Rovira Carballido1
1Department of Biotechnology and Food Science, University of Burgos, Plaza Misael Bañuelos, s/n. 09001 Burgos, Spain

Tài liệu tham khảo

Adeniyi, 2006, Mackerel (Scomber scrombrus) oil extraction and evaluation as raw materials for industrial utilization, Leonardo Journal of Sciences, 33 Aidos, 2003, Influence of production process parameters on fish oil quality in a pilot plant, Journal of food science, 68 Aidos, 2003, Quality of crude fish oil extracted from herring by-products of varying states of freshness, Journal of food science, 68, 458, 10.1111/j.1365-2621.2003.tb05694.x Aidos, 2001, Upgrading of maatjes herring byproducts: Production of crude fish oil, Journal of Agriculture and Food Chemistry, 49, 3697, 10.1021/jf001513s Alkio, 2000, Purification of polyunsaturated fatty acid esters from tuna oil with supercritical fluid chromatography, JAOCS, Journal of the American Oil Chemists' Society, 77, 315, 10.1007/s11746-000-0051-3 Al-Sayed-Mahmoud, 2008, Characterisation of the lipid fractions obtained by proteolitic and chemical extractions from rainbow trout (Oncorhynchus mykiss) roe, Process Biochemistry, 43, 376, 10.1016/j.procbio.2008.01.011 Ambring, 2006, Mediterranean-inspired diet lowers the ratio of serum phospholipids n−6 to n−3 fatty acids, the number of leukocytes and platelets and vascular endothelial growth factor in healthy subjects, American Journal of Clinical Nutrition, 83, 575, 10.1093/ajcn.83.3.575 Ando, 1992, Stereospecific analysis of fish oil triacyl-sn.glycerols, JAOCS, 69, 417, 10.1007/BF02540941 Andrich, 2005, Supercritical fluid extraction of bioactive lipids from the microalgae Nannochloropsis sp, European Journal of Lipid Science and Technology, 107, 381, 10.1002/ejlt.200501130 Antunes-Corrêa, 2008, Fractionation of fish oil with supercritical carbon dioxide, Journal of Food Engineering, 88, 381, 10.1016/j.jfoodeng.2008.02.025 Ariza-Ariza, 1998, Omega-3 fatty acids in rheumatoid arthritis: An overview, Seminars in Arthritis and Rheumatism, 27, 366, 10.1016/S0049-0172(98)80016-4 Behr, N., van-der-Mei, H., Sirtl, W., Schnegelberger, H. & von-Ettingshausen, O. (1984). Process for the preparation of spice extracts. Patent US 4.490.398. Belarbi, 2000, A process for high yield and scaleable recovery of high purity eicosapentaenoic acid esters from microalgae and fish oil, Process Biochemistry, 35, 951, 10.1016/S0032-9592(00)00126-6 Bergé, 2005, Fatty acids from lipids of marine organisms: Molecular biodiversity, roles as biomarkets, biologically active compounds, and economical aspects, Advances in Biochemical Engineering/Biotechnology, 96, 49, 10.1007/b135782 Bhale, 2007, Oregano and rosemary extracts inhibit oxidation of long-chain n−3 fatty acids in menhaden oil, Food Chemistry and Toxicology, 72, 504 Bhosle, 2005, New approaches in deacification of edible oils — A review, Journal of Food Engineering, 69, 481, 10.1016/j.jfoodeng.2004.09.003 Biscione, 2007, Cardiovascular effects of omega-3 free fatty acids, Current Vascular Pharmacology, 5, 163, 10.2174/157016107780368334 Bligh, 1959, A rapid method of total lipid extraction and purification, Candaian Journal of Biochemistry and Physiology, 37, 911, 10.1139/y59-099 Borch-Jensen, 1997, Phase equilibria of fish oil in sub- and supercritical carbon dioxide, Fluid Phase Equilibria, 138, 179, 10.1016/S0378-3812(97)00155-6 Borneo, 2007, Stability and consumer acceptance of long-chain omega-3 fatty acids (eicosapentaenoic acid, 20:5, n−3 and docosahexaenoic acid, 22:6, n−3) in cream-filled sandwich cookies, Journal of food science, 72, 49, 10.1111/j.1750-3841.2006.00240.x Boyd, 1992, A rapid method for determining the oxidation of n−3 fatty acids, Journal of the American Oil Chemists' Society, 69, 325, 10.1007/BF02636060 Brunner, G. (1994). Gas extraction. An introduction to fundamentals of supercritical fluids and the application to separation processes New York, Ed. Steinkopff Darmstadt Springer. Brunner, 2000, Fractionation of fats with supercritical carbon dioxide, European Journal of Lipid Science and Technology, 1, 240, 10.1002/(SICI)1438-9312(200003)102:3<240::AID-EJLT240>3.0.CO;2-Z Brunner, 1998 Burton, 1985, A mild, rapid and efficient method of lipid extraction for use in determining vitamin E / lipid ratios, Lipids, 20, 29, 10.1007/BF02534359 Calviello, 2007, n−3 polyunsaturated fatty acids and the prevention of colorectal cancer: Molecular mechanisms involved, Current Medicinal Chemistry, 14, 3059, 10.2174/092986707782793934 Cardozo, 2007, Metabolites from algae with economical impact, Comparative Biochemistry and Physiology, Part C, 146, 60 Carvalho, 2006, Microalgal reactors: A review of enclosed system designs and performances, Biotechnology Progress, 22, 1490, 10.1002/bp060065r Catchpole, 1998, Solubility of fish oil components in supercritical CO2 and CO2+ethanol mixtures, Journal of Chemical Engineering Data, 43, 1091, 10.1021/je980184l Catchpole, 2000, Fractionation of fish oils using supercritical CO2 and CO2+ethanol mixtures, Journal of Supercritical Fluids, 19, 25, 10.1016/S0896-8446(00)00075-9 Chang, S.S., Bao, Y. & Pelura, T.J. (1989). Purification of fish oil. Patent U.S. 4.874.629. Chantachum, 2000, Separation and quality of fish oil from precooked and non-precooked tuna heads, Food Chemistry, 69, 289, 10.1016/S0308-8146(99)00266-6 Chen, 2002, Screening of red algae filaments as potential alternative source of eicosapentaenoic acid, Marine Biotechnology, 4, 189, 10.1007/s10126-002-0002-4 Chen, 2007, Dietary fat — Gene interaction in cancer, Cancer Metastasis Reviews, 26, 535, 10.1007/s10555-007-9075-x Cheryan, 1998 Cheung, 1999, Temperature and pressure effects on supercritical carbon dioxide extraction of n−3 fatty acids from red seaweed, Food Chemistry, 65, 399, 10.1016/S0308-8146(98)00210-6 2000 Clayton, 2007, Long chain omega-3 polyunsaturated fatty acids in the treatment of psychiatric illnesses in children and adolescents, Acta Neuropsychiatrica, 19, 92, 10.1111/j.1601-5215.2007.00189.x Čmolík, 2000, Physical refining of edible oils, European Journal of Lipid Science and Technology, 102, 472, 10.1002/1438-9312(200008)102:7<472::AID-EJLT472>3.0.CO;2-Z Cocero, 2009, Encapsulation and co-precipitation processes with supercritical fluids: Fundamentals and applications, Journal of Supercritical Fluids, 47, 546, 10.1016/j.supflu.2008.08.015 Conchillo, 2006, Componentes funcionales en aceite de pescado y alga, Nutrición Hospitalaria, 21, 369 Das, 2008, Beneficial actions of polyunsaturated fatty acids in cardiovascular diseases: But, how and why?, Current Nutrition & Food Science, 4, 2, 10.2174/157340108783497418 Daukšas, 2005, Composition of fatty acids and lipid classes in bulk products generated during enzymic hydrolysis of cod (Gadus morhua) by-products, Process Biochemistry, 40, 2659, 10.1016/j.procbio.2004.12.012 Davarnejad, 2008, Extraction of fish oil by fractionation through supercritical carbon dioxide, Journal of Chemical and Engineering Data, 53, 2128, 10.1021/je800273c Desai, 2005, Recent developments in microencapsulation of food ingredients, Drying Technology, 23, 1361, 10.1081/DRT-200063478 Diamond, 2008, The rationale for the use of parenteral omega-3 lipids in children with short bowel syndrome and liver disease, Pediatric Surgery International, 24, 773, 10.1007/s00383-008-2174-0 Domingo, 2007, Omega-3 fatty acids and the benefits of fish consumption: Is all that glitters gold?, Environment International, 33, 993, 10.1016/j.envint.2007.05.001 Domingo, 2007, Benefits and risks of fish consumption I. A quantitative analysis of the intake of omega-3 fatty acids and chemical contaminants, Toxicology, 230, 219, 10.1016/j.tox.2006.11.054 Dunford, 1997, Supercritical CO2 extraction of oil and residual proteins from Atlantic mackerel (Scomber scombrus) as affected by moisture content, Journal of Food Science, 62, 289, 10.1111/j.1365-2621.1997.tb03987.x Dunford, 1998, Modelling of oil extraction with supercritical CO2 from Atlantic mackerel (Scomber scombrus) at different moisture contents, Journal of Supercritical Fluids, 13, 303, 10.1016/S0896-8446(98)00064-3 Dyerberg, 1986, The Eskimo experience, n-3 News, 1, 1 Espinosa, 2002, Thermodynamic modeling and process optimization of supercritical fluid fractionation of fish oil fatty acid ethyl esters, Industrial & Engineering Chemistry Research, 41, 1516, 10.1021/ie010470h Esquível, 1997, Supercritical carbon dioxide extraction of sardine Sardina pilchardus oil, Food Science and Technology, 30, 715 FAO, 1986, The production of fish meal and oil, vol. 142 Fernández-SanJuan, 2000, Fatty acid composition of commercial Spanish fast food and snack food, Journal of Food Composition and Analysis, 13, 275, 10.1006/jfca.2000.0893 Fleck, 1998, Fractionation of fatty acid ethyl esters by supercritical CO2: High separation efficiency using an automated countercurrent column, Journal of Supercritical Fluids, 14, 67, 10.1016/S0896-8446(98)00100-4 Fournier, 2006, Thermal degradation of long-chain polyunsaturated fatty acids during deodorization of fish oil, European Journal of Lipid Science and Technology, 108, 33, 10.1002/ejlt.200500290 Frankel, 1996, Evaluation of antioxidant activity of rosemary extracts, carnosol and carnosic acid in bulk vegetable oils and fish oil and their emulsions, Journal of the science of food and agriculture, 72, 201, 10.1002/(SICI)1097-0010(199610)72:2<201::AID-JSFA632>3.0.CO;2-Q Gámez-Meza, 2003, Concentration of eicosapentaenoic acid and docosahexaenoic acid from fish oil by hydrolysis and urea complexation, Food Research International, 36, 721, 10.1016/S0963-9969(03)00052-8 Gbogouri, 2006, Analysis of lipids extracted from salmon (Salmo salar) heads by commercial proteolytic enzymes, European Journal of Lipid Science and Technology, 108, 766, 10.1002/ejlt.200600081 Gharsallaoui, 2007, Applications of spray-drying in microencapsulation of food ingredients: An overview, Food Research International, 40, 1107, 10.1016/j.foodres.2007.07.004 Gironi, 2006, Separation of fish oils ethyl esters by means of supercritical carbon dioxide: Thermodynamic analysis and process modelling, Chemical Engineering Science, 61, 5114, 10.1016/j.ces.2006.03.041 Gorreta, 2002, Wax esters of n−3 polyunsaturated fatty acids: A new stable formulation as a potential food supplement. 1 — Digestion and absorption in rats, LWT - Food Science and Technology, 35, 458, 10.1006/fstl.2001.0888 Güçlü-Üstündağ, 2000, Correlating the solubility behavior of fatty acids, mono-, di-, and triglycerides, and fatty acid esters in supercritical carbon dioxide, Industrial & Engineering Chemistry Research, 39, 4756, 10.1021/ie0001523 Güçlü-Üstündağ, 2004, Correlating the solubility behavior of minor lipid components in supercritical carbon dioxide, Journal of Supercritical Fluids, 31, 235, 10.1016/j.supflu.2003.12.007 Gunnlaugsdottir, 1995, Lipase-catalyzed alcoholysis of cod liver oil in supercritical carbon dioxide, JAOCS, 72, 399, 10.1007/BF02636078 Gunnlaugsdottir, 1997, Lipase-catalyzed alcoholysis with supercritical carbon dioxide extraction 1: Influence of flow rate, JAOCS, 74, 1483, 10.1007/s11746-997-0258-y Gunnlaugsdottir, 1997, Lipase-catalyzed alcoholysis with supercritical carbon dioxide extraction 2: Phase behavior, JAOCS, 74, 1491, 10.1007/s11746-997-0259-x Gunnlaugsdottir, 1998, Process parameters influencing ethanolysis of cod liver oil in supercritical carbon dioxide, Journal of Supercritical Fluids, 12, 85, 10.1016/S0896-8446(97)00043-0 Guschina, 2006, Lipids and lipids metabolism in eukaryotic algae, Progress in Lipid Research, 46, 160, 10.1016/j.plipres.2006.01.001 Heinzelmann, 2000, Microencapsulation of fish oil by freeze-drying techniques and influence of process parameters on oxidative stability during storage, European Food Research and Technology, 211, 234, 10.1007/s002170000167 Horrobin, 1991, Fatty acid levels in the brains of schizophrenics and normal controls, Biological Psychiatry, 30, 795, 10.1016/0006-3223(91)90235-E Iafelice, 2008, Development of functional spaghetti enriched with long chain omega-3 fatty acids, Cereal Chemistry, 85, 146, 10.1094/CCHEM-85-2-0146 Imanishi, 1989, Supercritical fluid extraction of fish oil with carbon dioxide, R & D Kobe Engineering Reports, 39, 29 Jacobsen, 2008, Antioxidant strategies for preventing oxidative flavour deterioration of foods enriched with n−3 polyunsaturated lipids: A comparative evaluation, Trends in Food Science & Technology, 19, 76, 10.1016/j.tifs.2007.08.001 Jakobsson, 1991, Extraction of dioxins from cod liver oil by supercritical carbon dioxide, Journal of Supercritical Fluids, 4, 118, 10.1016/0896-8446(91)90039-9 Jakobsson, 1994, Counter-current extraction of dioxins from cod liver oil by supercritical carbon dioxide, Journal of Supercritical Fluids, 7, 197, 10.1016/0896-8446(94)90026-4 Jiménez-Álvarez, 2008, Antioxidant activity of oregano, parsley, and olive mill wastewaters in bulk oils and oil-in-water emulsions enriched in fish oil, Journal of Agricultural and Food Chemistry, 56, 7151, 10.1021/jf801154r Jiménez-Colmenero, 2006, Healthier lipid formulation approaches in meat-based functional food. Technological options for replacement of meat fats by non-meat fats, Trends in Food Science & Technology, 18, 567, 10.1016/j.tifs.2007.05.006 Kamal-Eldin, 2002, N−3 fatty acids for human nutrition: Stability considerations, European Journal of Lipid Science and Technology, 104, 825, 10.1002/1438-9312(200212)104:12<825::AID-EJLT825>3.0.CO;2-N Kamei, 2002, Nutritional evaluation of Japanese take-out lunches compared with Western-style fast foods supplied in Japan, Journal of Food Composition and Analysis, 15, 35, 10.1006/jfca.2001.1021 Kawashima, 2006, Experimental study on the removal of dioxins and coplanar polychlorinated biphenyls (PCBs) from fish oil, Journal of Agriculture and Food Chemistry, 54, 10294, 10.1021/jf061962d Kiran, 2000, 31 Klaypradit, 2008, Fish oil encapsulation with chitosan using ultrasonic atomizer, Lebensmittel-Wissenschaft Technologie, 41, 1133, 10.1016/j.lwt.2007.06.014 Knez, 2009, Enzymatic reactions in dense gases, Journal of Supercritical Fluids, 47, 357, 10.1016/j.supflu.2008.11.012 Kojima, 2006, Different specificity of two types of Pseudomonas lipases to C20 fatty acids with Δ5 unsaturated double bond and their application for selective concentration of fatty acids, Journal of Bioscience and Bioengineering, 101, 496, 10.1263/jbb.101.496 Kolanowski, 2006, Enrichement of food products with polyunsaturated fatty acids by fish oil addition, European Food Research and Technology, 222, 472, 10.1007/s00217-005-0089-8 Kolanowski, 2007, Sensory quality of dairy products fortified with fish oil, International Dairy Journal, 17, 1248, 10.1016/j.idairyj.2007.04.005 Kolanowski, 2007, Evaluation of sensory quality of instant foods fortified with omega-3 PUFA by addition of fish oil powder, European Food Research and Technology, 225, 715, 10.1007/s00217-006-0474-y Kromann, 1980, Epidemiological studies in the Upemavik district, Greenland, Acta Medica Scandinavica, 208, 401, 10.1111/j.0954-6820.1980.tb01221.x Kulångs, E. & Breivik, H. (2001). Recovery of polyunsaturated fatty acids from urea adducts. Patent WO 01/10809. Lands, 2008, A critique of paradoxes in current advice on dietary lipids, Progress in Lipid Research, 47, 77, 10.1016/j.plipres.2007.12.001 Lawson, 1988, Human absorption of fish oil fatty acids as triacylglycerols free fatty acids or ethyl esters, Biochemical and Biophysical Research Communications, 152, 328, 10.1016/S0006-291X(88)80718-6 LeGoffic, 2000 Letisse, 2006, Enrichment of EPA and DHA from sardine by supercritical fluid extraction without organic modifier. I. Optimization of extraction conditions, Journal of Supercritical Fluids, 38, 27, 10.1016/j.supflu.2005.11.013 Liaset, 2003, Chemical composition and theoretical nutrition evaluation of the produced fractions from enzyme hydrolysis of salmon with Protamex™, Process Biochemistry, 38, 1747, 10.1016/S0032-9592(02)00251-0 Lin, 2006, Enrichment of n−3 PUFA contents on triglycerides of fish oil by lipase-catalyzed trans-esterification under supercritical conditions, Biochemical Engineering Journal, 29, 27, 10.1016/j.bej.2005.02.035 Linder, 2002, Enrichment of salmon oil with n−3 PUFA by lipolysis, filtration and enzymatic re-esterification, European Journal of Lipid Science Technology, 104, 455, 10.1002/1438-9312(200208)104:8<455::AID-EJLT455>3.0.CO;2-Q Linder, 2005, Proteolytic extraction of salmon oil and PUFA concentration by lipases, Marine Biotechnology, 7, 70, 10.1007/s10126-004-0149-2 Liu, 2006, Concentration of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) of tuna oil by urea complexation: Optimization of process parameters, Journal of Food Engineering, 73, 203, 10.1016/j.jfoodeng.2005.01.020 Lyberg, 2005, Monitoring the oxidation of docosahexaenoic acid in lipids, Lipids, 40, 969, 10.1007/s11745-005-1458-1 MacLean, 2006, Effects of omega-3 fatty acids on cancer risk. A systematic review, Journal of the American Medical Association, 295, 403, 10.1001/jama.295.4.403 Maes, 2005, Removal of dioxins and PCB from fish oil by activated carbon and its influence on the nutritional quality of the oil, JAOCS, Journal of the American Oil Chemists' Society, 82, 593, 10.1007/s11746-005-1114-1 Martín, 2007, Mathematical modeling of the fractionation of liquids with supercritical CO2 in a countercurrent packed column, Journal of Supercritical Fluids, 39, 304, 10.1016/j.supflu.2006.03.004 Massaro, 2007, Omega-3 fatty acids, inflammation and angiogenesis: Nutrigenomic effects as an explanation for anti-atherogenic and anti-inflammatory effects of fish and fish oils, Journal of Nutrigenetics and Nutrigenomics, 1, 4 Mataix, 2003 Matsuno, 1993, Lipid encapsulation technology — Techniques and applications to food, Trends in Food Science & Technology, 4, 256, 10.1016/0924-2244(93)90141-V Mazza, 2007, Omega-3 fatty acids and antioxidants in neurological and psychiatric diseases: An overview, Progress in Neuro-Psychopharmacology & Biological Psychiatry, 31, 12, 10.1016/j.pnpbp.2006.07.010 McNamara, 2006, The emerging role of omega-3 fatty acids in phychiatry, Prostaglandins, Leukotriens and Essential Fatty Acids, 75, 223, 10.1016/j.plefa.2006.07.003 Mendes, 2003, Supercritical carbon dioxide extraction of compounds with pharmaceutical importance from microalgae, Inorganica Chimica Acta, 356, 328, 10.1016/S0020-1693(03)00363-3 Mendes, 2005, Supercritical CO2 extraction of γ-linolenic acid (GLA) from the cyanobacterium Arthrospira (Spirulina) maxima: Experiments and modeling, Chemical Engineering Science, 105, 147, 10.1016/j.cej.2004.10.006 Mendes, 2006, Supercritical CO2 extraction of γ-linolenic acid (GLA) from the cyanobacterium Arthrospira (Spirulina) maxima: Comparison with organic solvent extraction, Food Chemistry, 99, 57, 10.1016/j.foodchem.2005.07.019 Mishra, 1993, Extraction and purification of w-3 fatty acids with an emphasis on supercritical fluid extraction — A review, Food Research International, 26, 217, 10.1016/0963-9969(93)90056-O Napier, 2006, The production of n−3 long chain polyunsaturated fatty acids in transgenic plants, European Journal of Lipid Science and Technology, 108, 965, 10.1002/ejlt.200600180 Nishimoto, Y. & Nagagawa, M. (1996). Method for refining fish oil. Patent JP 08311481. Okada, 2007, Recovery and characterisation of sardine oil extracted by pH adjustment, Journal of Agriculture and Food Chemistry, 55, 1808, 10.1021/jf062942e Oliveira-Carvalho, 2003, Aplicação de lipases microbianas na obtenção de concentrados de ácidos graxos poliinsaturados, Quimica Nova, 26, 75, 10.1590/S0100-40422003000100014 Oterhals, 2007, Optimization of activated carbon-based decontamination of fish oil by response surface methodology, European Journal of Lipid Science and Technology, 109, 691, 10.1002/ejlt.200700083 Pérez-Mateos, 2006, Effects of rosemary and green tea extracts on frozen surimi gels fortified with omega-3 fatty acids, Journal of the science of food and agriculture, 86, 558, 10.1002/jsfa.2388 Perretti, 2007, Supercritical carbon dioxide fractionation of fish oil fatty acid ethyl esters, Journal of Supercritical Fluids, 40, 349, 10.1016/j.supflu.2006.07.020 Perrut, M., Nicoud, R.M. & Breivik, H. (1998). Processes for chromatographic fractionation of fatty acids and their derivatives. Patent US5719302. Pettinello, 2000, Production of EPA enriched mixtures by supercritical fluid chromatography: From the laboratory scale to the pilot plant, Journal of Supercritical Fluids, 19, 51, 10.1016/S0896-8446(00)00072-3 Ratledge, 2004, Fatty acid biosynthesis in microorganism being used for Single Cell Oil production, Biochimie, 86, 807, 10.1016/j.biochi.2004.09.017 Raventós, 2002, Application and possibilities of supercritical CO2 extraction in food processing industry: An overview, Food Science and Technology International, 8, 269, 10.1106/108201302029451 Razack, 2007, Nutrition in inflammatory bowel disease, Current Opinion in Gastroenterology, 23, 400, 10.1097/MOG.0b013e3281ddb2a3 Reisman, 2006, Treating asthma with omega-3 fatty acids: Where is the evidence? A systematic review, BMC Complementary and Alternative Medicine, 6, 26, 10.1186/1472-6882-6-26 Riha, 1999, Phase equilibrium of fish oil ethyl esters with supercritical carbon dioxide, Journal of Supercritical Fluids, 15, 33, 10.1016/S0896-8446(98)00130-2 Riha, 2000, Separation of fish oil ethyl esters with supercritical carbon dioxide, Journal of Supercritical Fluids, 17, 55, 10.1016/S0896-8446(99)00038-8 Robert, 2006, Production of eicosapentaenoic and docosahexaenoic acid-containing oils in transgenic land plants for human and aquaculture nutrition, Marine Biotechnology, 8, 103, 10.1007/s10126-005-5142-x Robles-Medina, 1998, Downstream processing of algal polyunsaturated fatty acids, Biotechnology Advances, 16, 517, 10.1016/S0734-9750(97)00083-9 Rolle, 1998, Review: Enzyme applications for agro-processing in developing countries: An inventory of current and potential applications, World Journal of Microbiology & Biotechnology, 14, 611, 10.1023/A:1008896500986 Ross, 2007, Omega-3 fatty acids as treatments for mental illness: Which disorder and which fatty acid?, Lipids in Health and Disease, 6, 1, 10.1186/1476-511X-6-21 Rubio-Rodríguez, 2008, Supercritical fluid extraction of the omega-3 rich oil contained in hake (Merluccius capensis–Merluccius paradoxus) byproducts: Study of the influence of process parameters on the extraction yield and oil quality, Journal of Supercritical Fluids, 47, 215, 10.1016/j.supflu.2008.07.007 Rubio-Rodríguez, 2009, SFE of fish oil from fish by-products: A comparison with other production processes Ruxton, 2005, The impact of long-chain n−3 polyunsaturated fatty acids on human health, Nutrition Research Reviews, 18, 113, 10.1079/NRR200497 Shahidi, 1998, Omega-3 fatty acid concentrates: Nutritional aspects and production technologies, Trends in Food Science & Technology, 9, 230, 10.1016/S0924-2244(98)00044-2 Shaikh, 2008, Polyunsaturated fatty acids and membrane organization: Elucidating mechanisms to balance immunotherapy and susceptibility to infection, Chemistry and Physics of Lipids, 153, 24, 10.1016/j.chemphyslip.2008.02.008 Sijtsma, 2004, Biotechnological production and applications of the ω-3 polyunsaturated fatty acid docosahexaenoic acid, Applied Microbiology and Biotechnology, 64, 146, 10.1007/s00253-003-1525-y Šližyte, 2005, Yield and composition of different fractions obtained after enzymatic hydrolysis of cod (Gadus morhua) by-products, Process Biochemistry, 40, 1415, 10.1016/j.procbio.2004.06.033 Šližyte, 2005, Enzymatic hydrolysis of cod (Gadus morhua) by-products. Optimization of yield and properties of lipid and protein fractions, Process Biochemistry, 40, 3680, 10.1016/j.procbio.2005.04.007 Snoey-Elich, H. (2001). Nuevo procedimiento de preparación del éster etílico del ácido eicosapentaenoico. Patent ES 2 159 257 A1. Spain. Song, 2007, Omega-3 fatty acid eicosapentaenoic acid. A new treatment for psychiatric and neurodegenerative diseases: A review of clinical investigations, Expert Opinion on Investigational Drugs, 16, 1627, 10.1517/13543784.16.10.1627 Spolaore, 2006, Commercial applications of microalgae, Journal of Bioscience and Bioengineering, 101, 87, 10.1263/jbb.101.87 Staby, 1993, Separation of constituents of fish oil using supercritical fluids: A review of experimental solubility, extraction, and chromatographic data, Fluid Phase Equilibria, 91, 349, 10.1016/0378-3812(93)85109-Y Stancík, 2006, Diet in the rheumatoid arthritis and the omega-3 fatty acids, Rheumatologia, 20, 159 Stillwell, 2003, Docosahexaenoic acid: Membrane properties of a unique fatty acid, Chemistry and Physics of Lipids, 126, 1, 10.1016/S0009-3084(03)00101-4 Turner, 2008, Omega 3 fatty acids (fish oil) for maintenance of remission in Crohn's disease, Cochrane database of systematic reviews (Online) Tziomalos, 2007, Fish oils and vascular disease prevention: An update, Current Medical Chemistry, 14, 2622, 10.2174/092986707782023307 Valencia, 2008, Enhancement of the nutritional status and quality of fresh pork sausages following the addition of linseed oil, fish oil and natural antioxidants, Meat Science, 80, 1046, 10.1016/j.meatsci.2008.04.024 vonSchacky, 2007, Cardiovascular benefits of omega-3 fatty acids, Cardiovascular Research, 73, 310, 10.1016/j.cardiores.2006.08.019 Wada, 1992, The synergistic antioxidant effect of rosemary extract and α-tocopherol in sardine oil model system and frozen-crushed fish meat, Journal of Food Processing and Preservatives, 195, 95 Ward, 2005, Omega-3/6 fatty acids: Alternative sources of production, Process Biochemistry, 40, 3627, 10.1016/j.procbio.2005.02.020 Wen, 2003, Heterotrophic production of eicosapentaenoic acid by microalgae, Biotechnology Advances, 21, 273, 10.1016/S0734-9750(03)00051-X WHO/FAO, 1994 Wijesundera, 2008, Docosahexaenoic acid is more stable to oxidation when located at the sn−2 position of triacylglycerol compared to sn−1(3), Journal of the American Oil Chemists' Society, 85, 543, 10.1007/s11746-008-1224-z Wong, 2003, Lipase Yang, 2004, Purification of EPA-EE and DHA-EE with supercritical fluid chromatography, Journal of Chemical Engineering of Chinese Universities, 18, 293 Yoshikazu, 1997 Yuqian, H. & Huashi, G. (2001). Preparation of high-grade fish smell-eliminating fish oil. Patent CN1318634. Zosel, K. (1982). Process for the direct decaffeination of aqueous coffe extract solutions Patent US 4.3483422. Zulfakar, 2007, Is there a role for topically delivered eicosapentaenoic acid in the treatment of psoriasis?, European Journal of Dermatology, 17, 284