Proteomics analysis revealed the presence of inflammatory and oxidative stress markers in the plasma of migraine patients during the pain period

Aleshire, 1983, Localization of human prealbumin in choroid plexus epithelium, J. Histochem. Cytochem., 31, 608, 10.1177/31.5.6341455 Andreou, 2019, Mechanisms of migraine as a chronic evolutive condition, J. Headache Pain, 20, 1, 10.1186/s10194-019-1066-0 Bellei, 2015, Validation of potential candidate biomarkers of drug-induced nephrotoxicity and allodynia in medication-overuse headache, J. Headache Pain, 16, 1, 10.1186/s10194-015-0559-8 Bellei, 2017, Serum protein changes in a rat model of chronic pain show a correlation between animal and humans, Sci. Rep., 7, 1, 10.1038/srep41723 Bellei, 2020, Proteomic serum profile in menstrual-related and post menopause migraine, J. Pharmaceutical Biomed. Anal., 184, 10.1016/j.jpba.2020.113165 Bellei, 2021, Urinary Proteomics Reveals Promising Biomarkers in Menstrually Related and Post-Menopause Migraine, J. Clinical Med., 10, 1854, 10.3390/jcm10091854 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal. Biochem., 72, 248, 10.1016/0003-2697(76)90527-3 Chen, 2005, A modified protein precipitation procedure for efficient removal of albumin from serum, Electrophoresis, 26, 2117, 10.1002/elps.200410381 Cowan, 2021, Evidence that blood–CSF barrier transport, but not inflammatory biomarkers, change in migraine, while CSF sVCAM1 associates with migraine frequency and CSF fibrinogen. Headache: The Journal of Head and Face, Pain, 61, 536 Davalos, 2012, Fibrinogen as a key regulator of inflammation in disease, Semin. Immunopathol., 34, 43, 10.1007/s00281-011-0290-8 Davalos, 2012, Fibrinogen-induced perivascular microglial clustering is required for the development of axonal damage in neuroinflammation, Nat. Commun., 3, 1227, 10.1038/ncomms2230 Dobryszycka, 1997, Biological functions of haptoglobin-new pieces to an old puzzle, Eur. J. Clin. Chem. Clin. Biochem., 35, 647 Durham, 2013, Biomarkers associated with migraine and their potential role in migraine management. Headache: The Journal of Head and Face, Pain, 53, 1262 Dyballa, 2009, Fast and sensitive colloidal coomassie G-250 staining for proteins in polyacrylamide gels, JoVE (Journal of Visualized Experiments), e1431 Farajzadeh, 2018, Different pain states of trigeminal neuralgia make significant changes in the plasma proteome and some biochemical parameters: a preliminary cohort study, J. Mol. Neurosci., 66, 524, 10.1007/s12031-018-1183-2 Fex, 1980, Subunit exchange between human and dog prealbumins, Scand. J. Clin. Lab. Invest., 40, 71, 10.3109/00365518009091529 Fleming, 2009, Transthyretin: an enhancer of nerve regeneration, Int. Rev. Neurobiol., 87, 337, 10.1016/S0074-7742(09)87017-7 Frederiksen, 2020, Serotonin and Neuropeptides in Blood From Episodic and Chronic Migraine and Cluster Headache Patients in Case-Control and Case-Crossover Settings: A Systematic Review and Meta-Analysis. Headache: The Journal of Head and Face, Pain, 60, 1132 Ghoreishy, 2022, Associations between potential inflammatory properties of the diet and frequency, duration, and severity of migraine headaches: a cross-sectional study, Sci. Rep., 12, 2878, 10.1038/s41598-022-06819-y Gião, 2020, Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer’s Disease, Int. J. Mol. Sci., 21, 2075, 10.3390/ijms21062075 Gül, 2021, New Indicator of Inflammation in Migraine: Red Blood Cell Distribution, Haydarpaşa Numune Med. J., 61, 166 Herbert, 1986, Transthyretin: A choroid plexus-specific transport protein in human brain: The 1986 S. Weir Mitchell Award, Neurology, 36, 900, 10.1212/WNL.36.7.900 Ihs, 2018, Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, Cephalalgia, 38, 1, 10.1177/0333102417738202 Imamura, 2008, Increased plasma matrix metalloproteinase-9 levels in migraineurs. Headache: The Journal of Head and Face, Pain, 48, 135 Karami, 2013, Crocin improved locomotor function and mechanical behavior in the rat model of contused spinal cord injury through decreasing calcitonin gene related peptide (CGRP), Phytomedicine, 21, 62, 10.1016/j.phymed.2013.07.013 Kim, 2015, Transthyretin as a new transporter of nanoparticles for receptor-mediated transcytosis in rat brain microvessels, Colloids Surf., B, 136, 989, 10.1016/j.colsurfb.2015.10.050 Krymchantowski, 2020, Medication overuse headache: an overview of clinical aspects, mechanisms, and treatments, Expert Rev. Neurother., 20, 591, 10.1080/14737175.2020.1770084 Kursun, 2021, Migraine and neuroinflammation: the inflammasome perspective, J. Headache Pain, 22, 55, 10.1186/s10194-021-01271-1 Liz, 2020, A narrative review of the role of transthyretin in health and disease, Neurology and Therapy, 9, 395, 10.1007/s40120-020-00217-0 Martami, 2018, The serum level of inflammatory markers in chronic and episodic migraine: a case-control study, Neurological Sci., 39, 1741, 10.1007/s10072-018-3493-0 Martami, 2018, The serum level of inflammatory markers in chronic and episodic migraine: a case-control study, Neurological Sciences, 39, 1741, 10.1007/s10072-018-3493-0 Mirmiranpour, 2012, Investigation of the mechanism(s) involved in decreasing increased fibrinogen activity in hyperglycemic conditions using L-lysine supplementation, Thromb. Res., 130, e13, 10.1016/j.thromres.2012.04.010 Nuutinen, 2009, Clusterin: a forgotten player in Alzheimer's disease, Brain Res. Rev., 61, 89, 10.1016/j.brainresrev.2009.05.007 Olsson, 2008, The lipocalin α 1-microglobulin protects erythroid K562 cells against oxidative damage induced by heme and reactive oxygen species, Free Radical Res., 42, 725, 10.1080/10715760802337265 Pellesi, 2020, Identification of candidate proteomic markers in the serum of medication overuse headache patients: An exploratory study, Cephalalgia, 40, 1070, 10.1177/0333102420921847 Perini, 2005, Plasma cytokine levels in migraineurs and controls. Headache: The Journal of Head and Face, Pain, 45, 926 Posch, 2014, Sample preparation guidelines for two-dimensional electrophoresis, Arch. Physiol. Biochem., 120, 192, 10.3109/13813455.2014.955031 Raghu, 2004, Interactions amongst plasma retinol-binding protein, transthyretin and their ligands: implications in vitamin A homeostasis and transthyretin amyloidosis, Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1703, 1, 10.1016/j.bbapap.2004.09.023 Ramachandran, 2018, Neurogenic inflammation and its role in migraine, Seminars Immunopathology, 40, 301, 10.1007/s00281-018-0676-y Razeghi Jahromi, 2018, Bariatric Surgery Promising in Migraine Control: a Controlled Trial on Weight Loss and Its Effect on Migraine Headache, Obes. Surg., 28, 87, 10.1007/s11695-017-2793-4 Rios, 2019, Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD, Sci. Rep., 9, 1, 10.1038/s41598-019-50071-w Ritchie, 2000, Reference distributions for the positive acute phase serum proteins, α1-acid glycoprotein (orosomucoid), α1-antitrypsin, and haptoglobin: A practical, simple, and clinically relevant approach in a large cohort, J. Clin. Lab. Anal., 14, 284, 10.1002/1098-2825(20001212)14:6<284::AID-JCLA7>3.0.CO;2-U Rodriguez-Rivera, 2021, Clusterin: Always protecting. Synthesis, function and potential issues, Biomed. Pharmacother., 134, 10.1016/j.biopha.2020.111174 Santos, 2016, Resveratrol administration increases transthyretin protein levels, ameliorating AD features: The importance of transthyretin tetrameric stability, Mol. Med., 22, 597, 10.2119/molmed.2016.00124 Shnayder, 2021, Candidate Genes and Proteomic Biomarkers of Serum and Urine in Medication-Overuse Headache, Int J Mol Sci, 22, 10.3390/ijms22169024 Steiner, T.J., Stovner, L.J., Birbeck, G.L., 2013. Migraine: the seventh disabler. 53, 227-229. 10.1186/1129-2377-14-1. Steiner, 2018, Migraine is first cause of disability in under 50s: will health politicians now take notice?, J. Headache Pain, 19, 17, 10.1186/s10194-018-0846-2 Tanik, 2015, Retinol-binding protein-4 and hs-CRP levels in patients with migraine, Neurological Sciences, 36, 1823, 10.1007/s10072-015-2262-6 Tekeşin, 2019, Evaluation of inflammatory markers in patients with migraine, Arch. Clinical Experimental Med., 4, 37, 10.25000/acem.494415 Togha, M., Jahromi, S.R., Ghorbani, Z., Ghaemi, A., Rafiee, P., 2020. Evaluation of Inflammatory State in Migraineurs: A Case-control Study. Iranian Journal of Allergy, Asthma and Immunology, 83-90. 10.18502/ijaai.v19i(s1.r1).2864. Togha, 2019, An investigation of oxidant/antioxidant balance in patients with migraine: a case-control study, BMC neurology, 19, 1, 10.1186/s12883-019-1555-4 Vyunova, 2016, A possible role of transthyretin in the biological mechanism of regulatory peptide neuroprotection, Mol. Genetics, Microbiol. Virol., 31, 143, 10.3103/S0891416816030101 Wiggers, 2022, Brain barriers and their potential role in migraine pathophysiology, J. Headache Pain, 23, 1, 10.1186/s10194-021-01365-w Wolf, 1987, Changes in serum enzymes, lactate, and haptoglobin following acute physical stress in international-class athletes, Clin. Biochem., 20, 73, 10.1016/S0009-9120(87)80102-9 Yazar, 2020, Evaluation of simple inflammatory blood parameters in patients with migraine, Ir. J. Med. Sci., 189, 677, 10.1007/s11845-019-02136-y Yuasa, 2018, Serum apolipoprotein E may be a novel biomarker of migraine, PLoS ONE, 13, e0190620, 10.1371/journal.pone.0190620