Descending facilitatory modulation of a behavioral nociceptive response by stimulation in the adult rat anterior cingulate cortex

European Journal of Pain - Tập 4 - Trang 83-96 - 2000
Amelita A. Calejesan1, Susan J. Kim1, Min Zhuo2
1Department of Anesthesiology, Washington University Medical Center, Washington University in St. Louis, St. Louis, MO, 63110, USA
2Department of Anatomy and Neurobiology, Washington University Medical Center, Washington University in St. Louis, St. Louis, MO, 63110, USA

Tóm tắt

It is well documented that the descending endogenous analgesia system, including the periaqueductal gray (PAG) and the rostral ventral medulla (RVM), play an important role in modulation of nociceptive transmission and morphine‐ and cannabinoid‐produced analgesia. Neurons in the PAG receive inputs from different nuclei of higher structures, including the anterior cingulate cortex (ACC). However, it is unclear if stimulation of neurons in the ACC modulates spinal nociceptive transmission. The present study has examined the effects of electrical stimulation and chemical activation of metabotropic glutamate receptors (mGluRs) in the ACC on a spinal nociceptive tail‐flick (TF) reflex induced by noxious heating. Activation of the ACC at high intensities (up to 500 μA) of electrical stimulation did not produce any antinociceptive effect. Instead, at most sites within the ACC (n = 36 of 41 sites), electrical stimulation produced significant facilitation of the TF reflex (i.e. decreases in TF latency). Chemical activation of mGluRs within the ACC also produced a facilitatory effect. Descending facilitation from the ACC apparently relays at the RVM. Electrical stimulation in the RVM produces a biphasic modulatory effect, showing facilitation at low intensities and inhibition at higher intensities. The present study provides evidence that activation of mGluRs within the ACC can facilitate spinal nociception. Copyright 2000 European Federation of Chapters of the International Association for the Study of Pain

Tài liệu tham khảo

Aimone D.L., 1986, Stimulation‐produced spinal inhibition from the midbrain in the rat is mediated by an excitatory amino acid transmitter in the medial medulla, J Neurosci, 6, 803, 10.1523/JNEUROSCI.06-06-01803.1986 10.1002/ana.410040511 10.1146/annurev.ne.07.030184.001521 10.1038/385074a0 10.1016/0006-8993(79)90942-9 10.1016/0006-8993(83)90108-7 10.1016/S0006-8993(98)00394-1 10.1016/0304-3959(84)90094-0 10.1093/brain/118.1.279 10.1152/jn.1987.57.1.289 10.1016/S0079-6123(08)62792-2 10.1523/JNEUROSCI.03-12-02545.1983 10.1146/annurev.ne.14.030191.001251 10.1038/306684a0 10.1016/0006-8993(91)90452-2 10.1007/978-1-4899-6704-6_18 10.1007/BF00230532 10.1007/BF00247901 Gebhart G.F., 1983, Inhibition of spinal nociceptive information by stimulation in the midbrain of the cat is blocked by lidocaine microinjected in nucleus raphe magnus and the medullary reticular formation, J Neurophysiol, 50, 1446, 10.1152/jn.1983.50.6.1446 Gebhart G.F., 1990, Brainstem Mechanisms of Behavior, 315 10.1002/cne.902060103 Haber L.H., 1980, Inhibition and excitation of primate spinothalamic tract neurons by stimulation in region of nucleus reticularis gigantocellularis, J Neurophysiol, 43, 1578, 10.1152/jn.1980.43.6.1578 10.1007/978-1-4684-4994-5_15 10.1523/JNEUROSCI.07-01-00271.1987 10.1113/jphysiol.1996.sp021352 Kaplan H., 1991, Hyperalgesia during acute opioid abstinence: evidence for a nociceptive facilitating function of the rostral ventromedial medulla, J Neuroscience, 11, 1433, 10.1523/JNEUROSCI.11-05-01433.1991 10.1038/31496 10.1016/0304-3959(93)90003-8 10.1152/jn.1986.56.3.555 10.1523/JNEUROSCI.13-06-02689.1993 McCreery D.B., 1979, Effects of stimulating in raphe nuclei and in reticular formation on response of spinothalamic neurons to mechanical stimuli, J Neurophysiol, 42, 166, 10.1152/jn.1979.42.1.166 McMahon S.B., 1988, Descending excitation and inhibition of spinal cord laminae I projection neurons, J Neurophysiol, 59, 1204, 10.1152/jn.1988.59.4.1204 10.1038/26481 10.1016/S0306-4522(98)00119-5 10.1016/0304-3959(95)00070-4 Paxinos G., 1986, The Rat Brain in Stereotaxic Coordinates, 2nd Edition. 10.1126/science.277.5328.968 10.1152/jn.1989.62.2.401 Ren K., 1990, Electrical stimulation of cervical vagal afferents. I. Central relays for modulation of spinal nociceptive transmission, J Neurophysiol, 64, 1098, 10.1152/jn.1990.64.4.1098 10.1016/0301-0082(96)00031-7 10.1016/0006-8993(84)91121-1 10.1038/385630a0 10.1152/jn.1992.68.5.1720 10.1126/science.2003220 Tanaka E., 1994, Opioid actions on rat anterior cingulate cortex neurons in vitro, J Neurosci, 14, 1106, 10.1523/JNEUROSCI.14-03-01106.1994 Thomas D.A., 1995, Microinjection of baclofen in the ventromedial medulla of rats: antinociception at low doses and hyperalgesia at high doses, J Pharmacol Exp Ther, 275, 274 10.1016/0304-3959(88)90094-2 10.1016/0304-3940(96)12978-5 10.1152/jn.1997.78.3.1550 10.1016/0006-8993(96)00631-2 10.1016/S0304-3959(98)00265-6 10.1111/j.1460-9568.1996.tb01608.x 10.1007/978-1-4899-6704-6_11 10.1016/S0304-3959(98)00212-7 10.1016/0006-8993(94)91044-8 10.1016/S0079-6123(08)62776-4 10.1097/00004691-199701000-00002 10.1016/0304-3959(90)91147-B 10.1016/0006-8993(91)90402-H 10.1152/jn.1992.67.6.1599 Zhuo M., 1993, Central pain modulation: descending facilitatory system, Prog Physiol Sci, 24, 252 10.1152/jn.1997.78.2.746 Zhuo M., 1998, The cingulate cortex biphasically regulates spinal nociception, Soc Neurosci Abst, 24, 1135
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European Journal of Pain

Tập 4

83-96

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