Ferrous Iron Induces Nrf2 Expression in Mouse Brain Astrocytes to Prevent Neurotoxicity

Keep, 2012, Intracerebral haemorrhage: mechanisms of injury and therapeutic targets, Lancet Neurol, 11, 720, 10.1016/S1474-4422(12)70104-7

Xi, 2006, Mechanisms of brain injury after intracerebral haemorrhage, Lancet Neurol, 5, 53, 10.1016/S1474-4422(05)70283-0

Crichton, 2002, Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells, J Inorg Biochem, 91, 9, 10.1016/S0162-0134(02)00461-0

Navarrete, 2014, The Cajal school and the physiological role of astrocytes: a way of thinking, Front Neuroanat, 8, 33, 10.3389/fnana.2014.00033

Barreto, 2011, Astrocytic-neuronal crosstalk: implications for neuroprotection from brain injury, Neurosci Res, 71, 107, 10.1016/j.neures.2011.06.004

Shih, 2003, Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress, J Neurosci, 23, 3394, 10.1523/JNEUROSCI.23-08-03394.2003

Tanaka, 1999, Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species, Glia, 28, 85, 10.1002/(SICI)1098-1136(199911)28:2<85::AID-GLIA1>3.0.CO;2-Y

Kaspar, 2009, Nrf2:INrf2 (Keap1) signaling in oxidative stress, Free Radic Biol Med, 47, 1304, 10.1016/j.freeradbiomed.2009.07.035

Zhao, 2007, Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage, Stroke, 38, 3280, 10.1161/STROKEAHA.107.486506

Vargas, 2009, The Nrf2-ARE cytoprotective pathway in astrocytes, Expert Rev Mol Med, 11, e17, 10.1017/S1462399409001094

Bell, 2011, Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning, Proc Natl Acad Sci USA, 108, E1, 10.1073/pnas.1015229108

He, 2015, Interleukin-1beta protects astrocytes against oxidant-induced injury via an NF-kappaB-dependent upregulation of glutathione synthesis, Glia, 63, 1568, 10.1002/glia.22828

Zhao, 2012, Pseudolaric acid B induces apoptosis via proteasome-mediated Bcl-2 degradation in hormone-refractory prostate cancer DU145 cells, Toxicol In Vitro, 26, 595, 10.1016/j.tiv.2012.02.004

Huang, 2002, Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products, J Neurosurg, 96, 287, 10.3171/jns.2002.96.2.0287

Pelizzoni, 2011, Iron handling in hippocampal neurons: activity-dependent iron entry and mitochondria-mediated neurotoxicity, Aging Cell, 10, 172, 10.1111/j.1474-9726.2010.00652.x

Kress, 2002, The relationship between intracellular free iron and cell injury in cultured neurons, astrocytes, and oligodendrocytes, J Neurosci, 22, 5848, 10.1523/JNEUROSCI.22-14-05848.2002

Winyard, 2005, Oxidative activation of antioxidant defence, Trends Biochem Sci, 30, 453, 10.1016/j.tibs.2005.06.001

Calkins, 2009, The Nrf2/ARE pathway as a potential therapeutic target in neurodegenerative disease, Antioxid Redox Signal, 11, 497, 10.1089/ars.2008.2242

Ding, 2015, Posttreatment with 11-keto-beta-boswellic acid ameliorates cerebral ischemia-reperfusion injury: Nrf2/HO-1 pathway as a potential mechanism, Mol Neurobiol, 52, 1430, 10.1007/s12035-014-8929-9

Wang, 2007, Role of Nrf2 in protection against intracerebral hemorrhage injury in mice, Free Radic Biol Med, 43, 408, 10.1016/j.freeradbiomed.2007.04.020

Chen, 2005, Increasing expression of heme oxygenase-1 by proteasome inhibition protects astrocytes from heme-mediated oxidative injury, Curr Neurovasc Res, 2, 189, 10.2174/1567202054368344

Cheng, 2015, Ferritin heavy chain mediates the protective effect of heme oxygenase-1 against oxidative stress, Biochim Biophys Acta, 1850, 2506, 10.1016/j.bbagen.2015.09.018

Li, 2009, Increasing expression of H- or L-ferritin protects cortical astrocytes from hemin toxicity, Free Radic Res, 43, 613, 10.1080/10715760902942808