Effect of hypoxia on the binding and subcellular distribution of iron regulatory proteins

Molecular and Cellular Biochemistry - Tập 301 Số 1-2 - Trang 21-32 - 2007
Tania Christova1, Douglas M. Templeton1
1Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada

Tóm tắt

Từ khóa


Tài liệu tham khảo

Andrews N (2000) Iron homeostasis: insights from genetics and animal models. Nat Rev Genet 1:208–217

Lieu PT, Heiskala M, Peterson PA, Yang Y (2001) The role of iron in health and disease. Mol Aspects Med 22:1–87

Halliwell B, Gutteridge JMC (1990) Role of free radicals and catalytic metal ions in human disease: an overview. Methods Enzymol 186:1–88

Hentze MW, Kühn LC (1996) Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress. Proc Natl Acad Sci USA 93:8175–8182

Eisenstein RS (2000) Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annu Rev Nutr 20:627–662

Schneider BD, Leibold EA (2000) Regulation of mammalian iron homeostasis. Curr Opin Clin Nutr Metab Care 3:267–273

Klausner RD, Rouault TA, Harford JB (1993) Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 72:19–28

Kennedy MC, Mende-Mueller L, Blondin GA, Beinert H (1992) Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein. Proc Natl Acad Sci USA 89:11730–11734

Guo B, Yu Y, Leibold EA (1994) Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity. J Biol Chem 269:24252–24260

Guo B, Phillips JD, Yu Y, Leibold EA (1995) Iron regulates the intracellular degradation of iron regulatory protein 2 by the proteasome. J Biol Chem 270:21645–21651

Henderson BR, Kühn LC (1995) Differential modulation of the RNA-binding proteins IRP-1 and IRP-2 in response to iron – IRP-2 inactivation requires translation of another protein. J Biol Chem 270:20509–20515

Pantopoulos K, Mueller S, Atzberger A, Ansorge W, Stremmel W, Hentze MW (1997) Differences in the regulation of iron regulatory protein-1 (IRP-1) by extra- and intracellular oxidative stress. J Biol Chem 272:9802–9808

Pantopoulos K, Hentze MW (1998) Activation of iron regulatory protein-1 by oxidative stress in vitro. Proc Natl Acad Sci USA 95:10559–10563

Drapier J-C, Hirling H, Weitzerbin J, Kaldy P, Kühn LC (1993) Biosynthesis of nitric oxide activates iron regulatory factor in macrophages. EMBO J 12:3643–3649

Pantopoulos K, Hentze MW (1995) Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts. Proc Natl Acad Sci USA 92:1267–1271

Phillips JD, Kinikini DV, Yu Y, Guo B, Leibold EA (1996) Differential regulation of IRP1 and IRP2 by nitric oxide in rat hepatoma cells. Blood 87:2983–2992

Eisenstein RS, Tuazon PT, Schalinske KL, Anderson SA, Traugh JA (1993) Iron-responsive element-binding protein. Phosphorylation by protein kinase C. J Biol Chem 268:27363–27370

Schalinske KL, Eisenstein RS (1996) Phosphorylation and activation of both iron regulatory proteins 1 and 2 in HL-60 cells. J Biol Chem 271:7168–7176

Brown NM, Anderson SA, Steffen DW, Carpenter TB, Kennedy MC, Walden WE, Eisenstein RS (1998) Novel role of phosphorylation in Fe-S cluster stability revealed by phosphomimetic mutations at Ser-138 of iron regulatory protein 1. Proc Natl Acad Sci USA 95:15235–15240

Fillebeen C, Chahine D, Caltagirone A, Segal P, Pantopoulos K (2003) A phosphomimetic mutation at Ser-138 renders iron regulatory protein 1 sensitive to iron-dependent degradation. Mol Cell Biol 23:6973–6981

Hanson ES, Leibold EA (1998) Regulation of iron regulatory protein 1 during hypoxia and hypoxia/reoxygenation. J Biol Chem 273:7588–7593

Schneider BD, Leibold EA (2003) Effects of iron regulatory protein regulation on iron homeostasis during hypoxia. Blood 102:3404–3411

Meyron-Holtz EG, Ghosh MC, Rouault TA (2004) Mammalian tissue oxygen levels modulate iron-regulatory protein activities in vivo. Science 306:2087–2090

Irace C, Scorziello A, Maffettone C, Pignataro G, Matrone C, Adornetto A., Santamaria R, Annunziato L, Colonna A (2005) Divergent modulation of iron regulatory proteins and ferritin biosynthesis by hypoxia/reoxygenation in neurons and glial cells. J Neurochem 95:1321–1331

Semenza GL (2000) Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. J Clin Invest 106:809–812

Hanson ES, Foot LM, Leibold EA (1999) Hypoxia post-translationally activates iron-regulatory protein 2. J Biol Chem 274:5047–5052

Tacchini L, Bianchi L, Bernelli-Zazzera A, Cairo G (1999) Transferrin receptor induction by hypoxia: HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation. J Biol Chem 274:24142–24146

Rouault TA (2002) Post-transcriptional regulation of human iron metabolism by iron regulatory proteins. Blood Cells Mol Dis 29:309–314

Toth I, Yuan LP, Rogers JT, Boyce H, Bridges KR (1999) Hypoxia alters iron-regulatory protein-1 binding capacity and modulates cellular iron homeostasis in human hepatoma and erythroleukemia cells. J Biol Chem 274:4467–4473

Seiser C, Posch M, Thompson N, Kühn LC (1995) Effect of transcription inhibitors on the iron-dependent degradation of transferrin receptor mRNA. J Biol Chem 270:29400–29406

Chen OS, Schalinske KL, Eisenstein RS (1997) Dietary iron intake modulates the activity of iron regulatory proteins and the abundance of ferritin and mitochondrial aconitase in rat liver. J Nutr 127:238–248

Piñero DJ, Li N, Hu J, Beard JL, Connor JR (2001) The intracellular location of iron regulatory proteins is altered as a function of iron status in cell cultures and rat brain. J Nutr 131:2831–2836

Campanella A, Levi S, Cairo G, Biasiotto G, Arosio P (2004) Blotting analysis of native IRP1: a novel approach to distinguish the different forms of IRP1 in cells and tissues. Biochemistry 43:195–204

Patton SM, Piñero DJ, Surguladze N, Beard J, Connor JR (2005) Subcellular localization of iron regulatory proteins to Golgi and ER membranes. J Cell Sci 118:4365–4373

Metzen E, Wolff M, Fandrey J, Jelkmann W (1995) Pericellular PO2 and O2 consumption in monolayer cell cultures. Respir Physiol 100:101–106

Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH (1998) Subcellular distribution and turnover of presenilins in transfected cells. J Biol Chem 273:12436–12442

Toescu EC (2004) Hypoxia sensing and pathways of cytosolic Ca2+ increases. Cell Calcium 36:187–199

Rolfs A, Kvietikova I, Gassmann M, Wenger RH (1997) Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. J Biol Chem 272:20055–20062

Lok CN, Ponka P (1999) Identification of a hypoxia response element in the transferrin receptor gene. J Biol Chem 274:24147–24152

Mikhopadhyay CK, Mazumder B, Fox PL (2000) Role of hypoxia inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J Biol Chem 275:31609–31615

Borgese N, Colombo S, Pedrazzini E (2003) The tale of tail-anchored proteins: coming from the cytosol and looking for a membrane. J Cell Biol 161:1013–1019

Hochachka PW, Buck LT, Doll CJ, Land SC (1996) Unifying theory of hypoxia tolerance: molecular metabolic defense and rescue mechanisms for surviving oxygen lack. Proc Natl Acad Sci USA 93:9493–9498

Thomson AM, Rogers JT, Leedman PJ (2000) Thyrotropin-releasing hormone and epidermal growth factor regulate iron-regulatory protein binding in pituitary cells via protein kinase C-dependent and -independent signaling pathways. J Biol Chem 275:31609–31615

Silver LA, Erecinska M (1990) Intracellular and extracellular changes of [Ca2+] in hypoxia and ischemia in rat brain in vivo. J Gen Physiol 95:837–866

Gasbarrini A, Borie AB, Farghali H, Bender C, Francavilla A, Van Thiel D (1992) Effect of anoxia on intracellular ATP, Na+ i, Ca2+ i, Mg2+ i and cytotoxicity in rat hepatocytes. J Biol Chem 267:6654–6663