Walter Haas1, K Schilke1, Jeannette Brand1, Beate Amthor1, Karin Weyer1, P. Bernard Fourie1, Gisela Bretzel1, V. Sticht-Groh1, H. J. Bremer1
1Department of General Pediatrics, Children's Hospital, Heidelberg University, Germany. [email protected] Tóm tắt
A sample of 124 isoniazid (INH)-resistant and 88 susceptible strains of Mycobacterium tuberculosis complex from south, central, and west Africa was analyzed by direct sequence analysis and PCR-restriction fragment length polymorphism analysis of their catalase-peroxidase (katG) genes. Point mutations at codon 315 were found in the genomes of 64% of INH-resistant strains, but no complete deletions were identified. Mutations at codon 463 were independent of INH resistance and were linked to the geographic origins of the strains.
