Cell of origin of transformed follicular lymphoma

Blood - Tập 126 - Trang 2118-2127 - 2015
Robert Kridel1,2, Anja Mottok1,2, Pedro Farinha1,2, Susana Ben-Neriah1, Daisuke Ennishi1, Yvonne Zheng1, Elizabeth A. Chavez1, Hennady P. Shulha1, King Tan1, Fong Chun Chan1, Merrill Boyle1, Barbara Meissner1, Adele Telenius1, Laurie H. Sehn1,3, Marco A. Marra4,5, Sohrab P. Shah2,6, Christian Steidl1,2, Joseph M. Connors1,3, David W. Scott1,3, Randy D. Gascoyne1,2
1Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, BC, Canada;
2Department of Pathology and Laboratory Medicine, and
3Department of Medicine, University of British Columbia, Vancouver, BC, Canada
4Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, BC, Canada
5Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada; and
6Molecular Oncology, BC Cancer Agency, Vancouver, BC, Canada

Tóm tắt

Key Points TFL is most commonly of the germinal center B-cell-like phenotype, but a significant minority of cases is of the ABC phenotype (16%). The absence of BCL2 translocation in FL at diagnosis is associated with transformation into ABC-like large cell lymphoma.

Tài liệu tham khảo

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