Renal Clearance Studies on the Horse
Tóm tắt
In 45 observations on 5 mares, penicillin clearance was found to be 829 ± 187 ml/min. per 100 kgm of body weight and 314 ± 103 per 100 gm of kidney weight. The ratio of penicillin clearance/inulin clea-rance was 4.79 ± 1.04. Corresponding values for diodrast clearance in one mare (7 obs.) was 691 ± 81 and 302 ± 36. The ratio of diodrast clearance/inulin clearance was 4.15 ± 0.30. Sulfathiazole clearance was studied in 39 observations on 4 mares. At sulfathiazole plasma concentrations below 50, ug/ml, plasma clearance was found to be 184 ± 48 ml/min. per 100 kgm of body weight and 67 ± 15 per 100 gm of kidney weight, while ultrafiltrate clearance was 537 ± 242 ml/min. per 100 kgm of body weight and 192 ± 72 per 100 gm of kidney weight (17 obs.) , The ratio of plasma clearance/ creatinine clearance was 1.25 ± 0.22 and the ratio of ultrafiltrate clearance/creatinine clearance 3.57 ± 1.28. Self-depression was manifest at higher plasma concentrations. Blocking of the tubular secretion of sulfathiazole by diodrast resulted in plasma clearance identical with creatinine clearance, whereas ultrafiltrate clearance dropped to values essentially lower than inulin clearance. In 35 observations on 3 mares sulfadimidine plasma clearance was found to be 35 ± 16 ml/min. per 100 kgm of body weight and 14 ± 7 per 100 gm of kidney weight. Ultrafiltrate clearance was 66 ± 23 ml/min. per 100 kgm of body weight and 27 ± 12 per 100 gm of kidney weight. The ratio of plasma clearance/creatinine clearance was 0.25 ± 0.10 and the ratio of ultrafiltrate clearance/creatinine clearance was 0.49 ± 0.14. Selfdepression was not demonstrated. It is concluded that the tubular secretion of penicillin and sulfathiazole as well as the tubular back-diffusion of sulfadimidine offer an adequate explanation of the slope of the blood concentration/time cur ves of these compounds.
Tài liệu tham khảo
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