Mutations in linker histone genes HIST1H1 B, C, D, and E; OCT2 (POU2F2); IRF8; and ARID1A underlying the pathogenesis of follicular lymphoma

Blood - Tập 123 Số 10 - Trang 1487-1498 - 2014
Hongxiu Li1, Mark Kaminski1, Yifeng Li1, Mehmet Ali Yıldız1, Peter Ouillette1, Siân Jones2, Heather Fox1, Kathryn Jacobi1, Kamlai Saiya-Cork1, Dale Bixby1, Daniel Lebovic1, Diane Roulston3, Kerby Shedden4, Michael Sabel5, Lawrence J. Marentette6, Vincent M. Cimmino5, Alfred E. Chang5, Sami N. Malek1
1Department of Internal Medicine, Division of Hematology and Oncology, University of Michigan, Ann Arbor, MI
2Personal Genome Diagnostics, Baltimore, MD;
3Department of Pathology
4Department of Statistics University of Michigan Ann Arbor MI United States
5Department of Surgery and
6Department of Ear, Nose and Throat, University of Michigan, Ann Arbor, MI

Tóm tắt

Key Points FL carries mutations in linker histone H1 B, C, D, and E genes in 27% of cases. FL carries recurrent mutations in OCT2 (POU2F2), IRF8, and ARID1A.

Từ khóa


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