Malignant astrocytomas of the spinal cord

Journal of Neurosurgery - Tập 70 Số 1 - Trang 50-54 - 1989
Alan R. Cohen1, Jeffrey H. Wisoff, Jeffrey C. Allen, Fred J. Epstein
1Department of Neurosurgery, New York University Medical Center, New York

Tóm tắt

✓ The authors review their experience with the operative management of 19 consecutive cases of malignant astrocytoma of the spinal cord. There was a male to female ratio of 1.1:1, and the median age of the population was 14 years (range 1 to 32 years). The median duration of symptoms prior to definitive diagnosis was 7 weeks. Radical excision was carried out in all cases, with 18 patients (95%) receiving radiotherapy and 10 patients (53%) receiving chemotherapy as well. To date, 15 (79%) of the 19 patients in this series have died, with a median survival period of 6 months following surgery. No patient improved after operation. Hydrocephalus was present in 11 patients (58%), seven of whom underwent ventricular shunting procedures. Dissemination of disease was found in 11 patients (58%). Extraneural metastases did not occur in the absence of a ventricular shunt. The authors conclude that malignant astrocytomas of the spinal cord are heralded by a short history followed by rapid neurological deterioration and usually death. The rationale for operation is discussed, and an aggressive approach utilizing adjuvant therapy directed at the entire neuraxis is suggested.

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Tài liệu tham khảo

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Journal of Neurosurgery

Tập 70 Số 1

50-54

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