Extending Healthy Life Span—From Yeast to Humans

American Association for the Advancement of Science (AAAS) - Tập 328 Số 5976 - Trang 321-326 - 2010
Luigi Fontana1,2, Linda Partridge3, Valter D. Longo4
1Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St. Louis, MO 63110, USA
2Division of Nutrition and Aging, Istituto Superiore di Sanità, Rome, Italy
3Institute of Healthy Aging, and G.E.E., University College London, London WC1E 6BT, UK.
4Andrus Gerontology Center and Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA

Tóm tắt

Eat Less, Live Long Studies in several model organisms have shown that dietary restriction without malnutrition, or manipulation of nutrient-sensing pathways through mutations or drugs, can increase life span and reduce age-related disease. Fontana et al. (p. 321 ) review the ways in which nutrient-sensing pathways are central to aging. Studies of yeast, worms, rodents, and primates show that these pathways are conserved during evolution. Although data on the effects of dietary restriction in primates are very limited, in humans, the protective effects of dietary restriction against cancer, cardiovascular disease, and diabetes must be judged against potentially negative long-term effects. More work is needed to determine whether dietary restriction and the modulation of anti-aging pathways through drugs can extend life span and reduce pathologies in humans.

Từ khóa


Tài liệu tham khảo

10.1177/0192623308329476

10.1001/jama.297.9.986

10.1371/journal.pgen.0030057

10.1126/science.1115535

10.1101/gad.1381406

10.1371/journal.pgen.1000467

10.18632/aging.100016

10.1016/j.cell.2008.02.037

10.1126/science.1059497

10.1126/science.289.5487.2126

10.1371/journal.pbio.0050261

10.1371/journal.pgen.0040013

10.1016/j.cell.2005.08.042

10.4161/cc.8.8.8287

10.1083/jcb.137.7.1581

10.1111/j.1474-9726.2007.00326.x

10.1371/journal.pgen.0030084

10.1016/j.tem.2009.03.006

10.1101/gad.504808

10.1016/S0092-8674(03)00889-4

10.1371/journal.pgen.0040024

10.1111/j.1365-2796.2007.01906.x

10.1371/journal.pgen.1000486

10.1126/science.1173507

10.1146/annurev.biochem.77.061206.171059

10.1111/j.1474-9726.2009.00459.x

10.1186/1471-213X-8-49

10.1111/j.1474-9726.2008.00385.x

10.1016/j.cell.2008.01.030

10.1186/gb-2007-8-7-r132

10.1371/journal.pgen.1000857

10.1073/pnas.0405775102

10.1016/j.cub.2004.03.059

10.1016/j.cmet.2009.11.010

10.1098/rspb.1996.0113

10.1093/gerona/62.10.1071

10.1038/nmeth0308-214

10.1038/nature08619

10.1126/science.1136610

10.1111/j.1474-9726.2007.00362.x

10.1111/j.1474-9726.2008.00373.x

10.1210/en.2005-0411

10.1016/j.arr.2007.02.005

10.1016/j.cell.2007.05.038

10.1038/nature08221

10.1126/science.1177221

10.1111/j.1474-9726.2007.00300.x

10.1093/gerona/glp017

10.1016/j.mad.2008.04.013

10.1016/j.cmet.2008.06.011

10.1016/j.mad.2007.07.007

10.1371/journal.pone.0005963

10.1093/geronj/48.1.B27

10.1073/pnas.0712162105

10.1016/j.neurobiolaging.2004.09.014

10.1016/j.cell.2009.11.014

10.1073/pnas.0708100105

10.1016/0047-6374(96)01737-X

10.1007/s11357-008-9056-1

10.1016/j.ghir.2006.10.007

10.1111/apa.1991.80.s377.115

10.1210/jc.2007-1636

10.1073/pnas.0705467105

10.1210/jc.2002-021810

10.1038/sj.ejhg.5201766

10.1126/science.1173635

10.1073/pnas.0308291101

10.1111/j.1474-9726.2008.00417.x

10.1371/journal.pone.0004567

Thông tin
Thông tin xuất bản

American Association for the Advancement of Science (AAAS)

Tập 328 Số 5976

321-326

Thông tin tác giả