Precision extruding deposition and characterization of cellular poly‐ε‐caprolactone tissue scaffolds
Tóm tắt
Successes in scaffold guided tissue engineering require scaffolds to have specific macroscopic geometries and internal architectures to provide the needed biological and biophysical functions. Freeform fabrication provides an effective process tool to manufacture many advanced scaffolds with designed properties. This paper reports our recent study on using a novel precision extruding deposition (PED) process technique to directly fabricate cellular poly‐ε_rm;‐caprolactone (PCL) scaffolds. Scaffolds with a controlled pore size of 250
Tài liệu tham khảo
Bellini, A. (2002) “Fused deposition of ceramics: a comprehensive experimental, analytical and computational study of material behavior, fabrication process and equipment design”, PhD dissertation, Department of Mechanical Engineering and Mechanics, Drexel University.
Hollister, S.J., Maddox, R.D. and Taboas, J.M. (2002), “Optimal design and fabrication of scaffolds to mimic tissue properties and satisfy biological constraints”, Biomaterials, Vol. 23, pp. 4095‐103.
Hutmacher, D.W. (2000), “Scaffolds in tissue engineering bone and cartilage”, Biomaterials, Vol. 21, pp. 2529‐43.
Koch, K.U., Biesinger, B., Arnholz, C. and Jansson, V. (1998), “Creating of bio‐compatible, high stress resistant and resorbable implants using multiphase jet solidification technology”, Rapid News Publication, pp. 209‐14.
Lin, A.S.P., Barrows, T.H., Cartmell, S.H. and Guldberg, R.E. (2003), “Micro‐architectural and mechanical characterization of oriented porous polymer scaffolds”, Biomaterials, Vol. 24, pp. 481‐9.
Müller, R. and Rüegsegger, P. (1997), “Micro‐tomographic imaging for the nondestructive evaluation of trabecular bone architecture”, in Lowet, G. et al. (Eds), Bone Research in Biomechanics, IOS Press, Amsterdam, pp. 61‐80.
Müller, R., Matter, S., Neuenschwander, P., Suter, U.W. and Rüegsegger, P. (1996), “3D Micro tomographic imaging and quantitative morphometry for the nondestructive evaluation of porous biomaterials”, in Briber, R., Pfeiffer, D.G. and Han, C.C. (Eds), Morphological Control in Multiphase Polymer Mixtures, Mat. Res. Soc. Proc., 461, pp. 217‐22.
Sun, W. and Lal, P. (2002), “Recent development on computer aided tissue engineering – a review”, Computer Methods and Programs in Biomedicine, Vol. 67, pp. 85‐103.
Sun, W., Darling, A., Starly, B. and Nam, J. (2004a), “Computer aided tissue engineering: part I – overview, scope and challenges”, Journal of Biotechnology and Applied Chemistry, Vol. 34.
Sun, W., Starly, B., Darling, A. and Gomez, C. (2004b), “Computer aided tissue engineering: part II – application in biomimetic modeling and design of tissue scaffold”, Journal of Biotechnology and Applied Chemistry, Vol. 34, in preparation.
Taboas, J.M., Maddox, R.D., Krebsbach, P.H. and Hollister, S.J. (2003), “Indirect solid free form fabrication of local and global porous, biomimetic and composite 3D polymer‐ceramic scaffolds”, Biomaterials, Vol. 24, pp. 181‐94.
Van R., Müller, R., Ulrich, D., Rüegsegger, P. and Huiskes, R. (1999), “Tissue stresses and strain in trabeculae of canine proximal femur can be quantified from computer reconstructions”, J. Biomech., Vol. 32, pp. 165‐74.
Vozzi, G., Previti, A., Rossi, D. and Ahluwalia, A. (2002), “Microsyringe‐based deposition of two‐dimensional and three‐dimensional polymer scaffolds with a well‐defined geometry for application to tissue engineering”, Tissue Engineering, Vol. 8, pp. 1089‐98.
Wu, B.M., Borland, S.W., Giordano, R.A., Cima, L.G., Sachs, E.M. and Cima, M.J. (1996), “Solid free‐form fabrication of drug delivery devices”, Journal of Controlled Release, Vol. 40, pp. 77‐87.
Xiong, Z., Yan, Y., Zhang, R. and Sun, L. (2001), “Fabrication of porous poly(l‐lactic acid) scaffolds for bone tissue engineering via precise extrusion”, Scripta Materialia, Vol. 45, pp. 773‐9.
Yang, S., Leong, K., Du, Z. and Chua, C. (2002), “The design of scaffolds for use in tissue engineering. Part 2. Rapid prototyping techniques”, Tissue Engineering, Vol. 8 No. 1, pp. 1‐11.
Zein, I.W., Hutmacher, D.W., Tan, K.C. and Toch, S.H. (2002), “Fused deposition modeling of novel scaffold architecture for tissue engineering application”, Biomaterials, Vol. 23, pp. 1169‐85.