Control Mechanism of the Circadian Clock for Timing of Cell Division in Vivo
Tóm tắt
Cell division in many mammalian tissues is associated with specific times of day, but just how the circadian clock controls this timing has not been clear. Here, we show in the regenerating liver (of mice) that the circadian clock controls the expression of cell cycle–related genes that in turn modulate the expression of active Cyclin B1-Cdc2 kinase, a key regulator of mitosis. Among these genes, expression of
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Tài liệu tham khảo
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Materials and methods are available as supporting material on Science Online.
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The authors wish to thank M. Iwai (Kyoto Prefectural University of Medicine) for advising the technique of hepatectomy G. T. J. van der Horst (Erasmus University) for providing access to Cry -deficient mice and A. Ishida and T. Okamoto (Kobe University) for technical assistance. Supported in part by grants from the Special Coordination Funds; the Grant-in-Aid for the Scientific Research on Priority Areas of the Ministry of Education Culture Sports Science and Technology of Japan; the Kanae Foundation for Life and Sociomedical Science; and the Inamori Foundation.