Long-term trajectories of cognitive deficits in schizophrenia: A critical overview

European Psychiatry - Tập 30 - Trang 1002-1010 - 2015
A.B. Shmukler1, I.Y. Gurovich1, M. Agius2,3,4, Y. Zaytseva1,5,6,7
1Moscow Research Institute of Psychiatry, Moscow, Russian Federation
2Clare College Cambridge, Cambridge, UK
3Department of Psychiatry, University of Cambridge, Cambridge, UK
4East London NHS Foundation Trust, London, UK
5National Institute of Mental Health, Klecany, Charles University in Prague, Prague, Czech Republic
6Department of Psychiatry and Medical Psychology, 3rd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
7Human Science Centre and Institute of Medical Psychology, Ludwig-Maximilians Universität, Munich, Germany

Tóm tắt

AbstractBackgroundCognitive disturbances are widely pronounced in schizophrenia and schizophrenia spectrum disorders. Whilst cognitive deficits are well established in the prodromal phase and are known to deteriorate at the onset of schizophrenia, there is a certain discrepancy of findings regarding the cognitive alterations over the course of the illness.MethodsWe bring together the results of the longitudinal studies identified through PubMed which have covered more than 3 years follow-up and to reflect on the potential factors, such as sample characteristics and stage of the illness which may contribute to the various trajectories of cognitive changes.ResultsA summary of recent findings comprising the changes of the cognitive functioning in schizophrenia patients along the longitudinal course of the illness is provided. The potential approaches for addressing cognition in the course of schizophrenia are discussed.ConclusionsGiven the existing controversies on the course of cognitive changes in schizophrenia, differentiated approaches specifically focusing on the peculiarities of the clinical features and changes in specific cognitive domains could shed light on the trajectories of cognitive deficits in schizophrenia and spectrum disorders.

Tài liệu tham khảo

Zaytseva, 2010, Neurocognitive deficit changes in relation to the course of schizophrenia and schizophrenia spectrum disorders: 5-year follow-up study, Psychiatr Danub, 22, S149 10.1016/j.schres.2005.05.018 10.1016/j.psychres.2004.05.018 10.1016/j.schres.2008.02.022 10.1016/j.schres.2005.09.005 10.1192/bjp.bp.106.029009 10.1017/S0033291704003460 10.1016/S0920-9964(03)00014-8 10.1192/bjp.bp.107.035899 10.1093/schbul/sbi048 10.1016/j.schres.2004.03.007 10.1080/13803390500360471 10.1093/oxfordjournals.schbul.a033337 10.1176/appi.ajp.2009.09040574 10.1001/archpsyc.62.12.1297 10.1037/0033-2909.133.5.833 10.1016/j.biopsych.2008.04.011 10.1093/schbul/sbn014 10.1016/j.schres.2012.11.031 10.1037/0894-4105.11.3.437 10.1037/a0020855 10.1016/j.schres.2014.03.015 10.1037/a0014708 10.1176/appi.ajp.2013.12111438 10.1001/archpsyc.1993.01820170047006 10.1016/j.biopsych.2005.09.005 10.1093/schbul/sbp143 10.1037/0021-843X.114.4.599 10.1080/135468099396025 10.1111/j.1600-0447.2008.01213.x 10.1016/j.jpsychires.2007.02.001 10.1016/j.schres.2011.06.017 10.1001/jamapsychiatry.2013.155 10.1016/j.schres.2008.07.020 10.1016/S0140-6736(94)90569-X 10.1093/schbul/sbq057 10.1093/schbul/sbm168 10.1111/j.1600-0447.2004.00392.x 10.1017/S0033291700037697 Hoff, 1999, Longitudinal neuropsychological follow-up study of patients with first-episode schizophrenia, Am J Psychiatry, 156, 1336, 10.1176/ajp.156.9.1336 10.1586/ern.09.143 10.1080/13546800344000309 10.1037/0894-4105.12.3.426 10.1016/S0006-3223(98)00273-X 10.1002/1099-1166(200112)16:1+<::AID-GPS565>3.0.CO;2-V 10.1080/10673220127879 10.1093/schbul/sbt034 10.1192/bjp.178.6.506 Harding, 1987, The Vermont longitudinal study of persons with severe mental illness. II. Long-term outcomes of subjects who retrospectively met DSM-III criteria for schizophrenia, Am J Psychiatry, 144, 727, 10.1176/ajp.144.6.727 Harding, 1987, The Vermont longitudinal study of persons with severe mental illness. I. Methodology, study sample, and overall status 32 years later, Am J Psychiatry, 144, 718, 10.1176/ajp.144.6.718 10.1093/schbul/sbq171 10.1093/schbul/19.4.797 Gold, 1999, Longitudinal study of cognitive function in first episode and recent-onset schizophrenia, Am J Psychiatry, 156, 1342, 10.1176/ajp.156.9.1342 10.1017/S0033291711001693 10.1016/j.biopsych.2008.04.005 10.1001/archpsyc.64.5.532 10.1017/S0033291712000220 10.1016/j.eurpsy.2007.10.013 10.1016/S0920-9964(98)00109-1 10.1176/appi.ajp.2008.08060806 10.1176/appi.ajp.159.7.1183 10.1001/archpsyc.1992.01820030053007 10.1016/j.schres.2011.12.022 10.1016/j.schres.2008.03.015 Gurovich, 2012, Dynamics of neurocognitive functioning in patients in early stages of schizophrenia and schizophrenia spectrum disorders, Zh Nevrol Psikhiatr Im S S Korsakova, 112, 7 10.1176/appi.ajp.160.11.2060 10.4088/JCP.08m04846yel 10.1016/S0920-9964(97)00113-8 10.1016/j.schres.2011.06.014 10.1007/s11065-005-6254-9 10.4088/JCP.13m08355 10.1016/j.schres.2003.12.002 10.1111/j.1600-0447.2007.01014.x 10.1093/schbul/sbs135 10.1016/j.comppsych.2010.02.005 10.1176/appi.ajp.2013.13091283 10.1176/ajp.2007.164.7.1061 10.1176/appi.ajp.159.8.1388 10.1176/appi.ajp.2008.07081242 10.1001/archpsyc.1987.01800190080012 10.1001/archpsyc.1966.01730090099015 10.1001/archpsyc.56.3.241 10.1001/archpsyc.64.12.1348 10.1017/S0033291700036527 10.1016/j.schres.2005.05.010 Russell, 1997, Schizophrenia and the myth of intellectual decline, Am J Psychiatry, 154, 635, 10.1176/ajp.154.5.635 10.1016/j.biopsych.2007.05.022 10.1002/ajmg.b.30120 10.1017/S0033291706007951 Elvevog, 2000, Cognitive impairment in schizophrenia is the core of the disorder, Crit Rev Neurobiol, 14, 1 10.1016/j.neubiorev.2006.11.006 10.1192/bjp.136.5.413 10.1016/j.psychres.2014.01.031 10.1001/archpsyc.60.6.565 10.1016/j.pnpbp.2007.10.011 10.1176/appi.ajp.162.3.441 10.1001/archpsyc.58.1.24 10.3109/00048674.2010.541418 10.1016/j.psychres.2006.01.022 10.1080/09540260701496869 10.1192/bjp.187.6.500 10.1007/s00406-006-0667-1 Anon, 2013, Diagnostic and statistical manual of mental disorders (DSM-5) 10.1016/j.biopsych.2008.03.003 Bedwell, 1999, Why does postpsychotic IQ decline in childhood-onset schizophrenia?, Am J Psychiatry, 156, 1996, 10.1176/ajp.156.12.1996 10.1016/j.schres.2008.09.018 10.1007/s40263-012-0003-4 10.1080/13803390500360554 10.1093/schbul/sbt085 10.1016/S0920-9964(03)00056-2 10.1192/bjp.186.5.364 10.1176/appi.ajp.2013.13101303
Thông tin
Thông tin xuất bản

European Psychiatry

Tập 30

1002-1010

Thông tin tác giả