Differences in the expression of chromosome 1 genes between lung telocytes and other cells: mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells and lymphocytes

Journal of Cellular and Molecular Medicine - Tập 18 Số 5 - Trang 801-810 - 2014
Xiaoru Sun1,2, Minghuan Zheng3,4, Miaomiao Zhang3,4, Mengjia Qian3,4, Yonghua Zheng1, Meiyi Li5, Dragoș Crețoiu6,7, Chengshui Chen2, Luonan Chen5, Laurențiu M. Popescu8,7, Xiangdong Wang3,1,4
1Department of Pulmonary Medicine, Fudan University, Zhongshan Hospital, Shanghai Respiratory Research Institute, Shanghai, China
2Department of Pulmonary Medicine, The First affiliated Hospital, Wenzhou Medical University, Wenzhou, China
3Biomedical Research Center, Fudan University Zhongshan Hospital and Qinpu Hospital, Shanghai, China
4Fudan University Center for Clinical Bioinformatics, Shanghai, China
5State Key Laboratory of Systems Biology, Chinese Academy of Science, Shanghai, China
6Department of Molecular Medicine, Victor Babeş National Institute of Pathology, Bucharest, Romania
7Division of Cellular and Molecular Medicine, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania
8Division of Advanced Studies, Victor Babeş National Institute of Pathology, Bucharest, Romania

Tóm tắt

AbstractTelocytes (TCs) are a unique type of interstitial cells with specific, extremely long prolongations named telopodes (Tps). Our previous study showed that TCs are distinct from fibroblasts (Fbs) and mesenchymal stem cells (MSCs) as concerns gene expression and proteomics. The present study explores patterns of mouse TC‐specific gene profiles on chromosome 1. We investigated the network of main genes and the potential functional correlations. We compared gene expression profiles of mouse pulmonary TCs, MSCs, Fbs, alveolar type II cells (ATII), airway basal cells (ABCs), proximal airway cells (PACs), CD8+ T cells from bronchial lymph nodes (T‐BL) and CD8+ T cells from lungs (T‐LL). The functional and feature networks were identified and compared by bioinformatics tools. Our data showed that on TC chromosome 1, there are about 25% up‐regulated and 70% down‐regulated genes (more than onefold) as compared with the other cells respectively. Capn2, Fhl2 and Qsox1 were over‐expressed in TCs compared to the other cells, indicating that biological functions of TCs are mainly associated with morphogenesis and local tissue homoeostasis. TCs seem to have important roles in the prevention of tissue inflammation and fibrogenesis development in lung inflammatory diseases and as modulators of immune cell response. In conclusion, TCs are distinct from the other cell types.

Từ khóa


Tài liệu tham khảo

10.1111/j.1582-4934.2010.01059.x

10.1111/j.1582-4934.2012.01655.x

10.1111/j.1582-4934.2012.01523.x

10.1111/jcmm.12195

10.1111/j.1582-4934.2012.01582.x

10.1111/j.1582-4934.2011.01504.x

10.1111/j.1582-4934.2011.01506.x

10.1111/j.1582-4934.2012.01651.x

10.1111/j.1582-4934.2012.01583.x

10.1530/REP-12-0369

10.1111/j.1582-4934.2012.01580.x

10.1111/jcmm.12028

10.1042/CBI20120007

10.1111/jcmm.12134

10.1111/j.1582-4934.2011.01465.x

10.1111/jcmm.12015

10.1111/j.1582-4934.2011.01505.x

10.1111/jcmm.12111

10.1111/jcmm.12021

10.1111/jcmm.12057

10.1111/j.1582-4934.2011.01325.x

10.1111/j.1582-4934.2005.tb00502.x

10.1007/s00441-011-1229-z

10.1586/ers.11.91

10.1007/s00441-012-1333-8

10.1111/j.1582-4934.2011.01404.x

10.1111/jcmm.12295

10.1111/jcmm.12240

Zheng YH, 2012, [Location of telocytes in mouse bronchial and pulmonary tissues], Zhonghua Bing Li Xue Za Zhi, 41, 172

10.1111/jcmm.12052

10.1111/jcmm.12290

10.1111/j.1582-4934.2009.00758.x

Gene Expression Omnibus (GEO).http://www.ncbi.nlm.nih.gov/geo/

10.1038/nature04727

10.1186/gb-2007-8-6-218

10.1042/BJ20120921

10.1186/1471-213X-6-3

10.1097/MOH.0b013e3280ef68f8

10.1093/jb/mvr070

10.1152/ajplung.00349.2011

10.1074/jbc.M002519200

10.1093/emboj/21.4.736

10.1210/en.2012-1059

10.1073/pnas.1221637110

10.1182/blood-2012-08-446922

10.1128/MCB.00105-13

10.1371/journal.pone.0081356

10.1111/jcmm.12177

10.1111/jcmm.12228

10.1038/nature11267

10.1007/s10735-007-9156-8

10.1089/ars.2013.5572

10.1371/journal.pone.0086641

10.1089/jir.2009.0096

10.1002/ar.21540

10.1097/MPA.0b013e31823fbded

10.1016/j.cell.2006.01.055

10.1002/med.21293

10.1186/2001-1326-1-1

10.1186/2052-8426-1-1

10.1186/2052-8426-2-3

10.1186/2052-8426-1-3

Thông tin
Thông tin xuất bản

Journal of Cellular and Molecular Medicine

Tập 18 Số 5

801-810

Thông tin tác giả