Effect of acetazolamide and subsequent ventriculo-peritoneal shunting on clinical signs and ventricular volumes in dogs with internal hydrocephalus
Tóm tắt
Acetazolamide is recommended for the reduction of cerebrospinal fluid production in canine internal hydrocephalus. The efficacy of the drug in terms of alleviation of the clinical symptoms and the restoration of normal ventricular volume has not been documented. We hypothesize that acetazolamide inadequately improve clinical signs and has no effect on the ventricular volume. Six dogs with internal hydrocephalus underwent neurological examination and were examined by magnetic resonance imaging, on the day of the diagnosis, after treatment with acetazolamide directly before surgery, and 6 weeks after implantation of a vetriculo-peritoneal shunt due to lack of improvement after medical therapy with 10 mg/kg acetazolamide three times daily (TID). The ventricular volume in relation to the total brain volume was determined on each occasion. The changes in relative ventricular volume and of the neurological status were assessed and compared. McNemar’s test revealed no significant differences in clinical symptoms before and after medical treatment (P > 0.05). However, clinical symptoms changed significantly after surgical treatment (P = 0.001). The ventricle-brain ratio was not significantly changed after therapy with acetazolamide (P > 0.05); however, after subsequent shunt implantation, it was significantly reduced (P = 0.001). Acetazolamide (10 mg/kg TID) showed no effects on clinical signs or ventricular volume in dogs with internal hydrocephalus. After subsequent ventriculo-peritoneal shunting, the dogs had a significantly reduced cerebral ventricular volume and five out of six dogs had no abnormal findings in neurological examination.
Tài liệu tham khảo
DeLahunta A, Glass E (2014) Malformations. In: Veterinary neuroanatomy and clinical neurology. Saunders Elsevier, Missouri, pp 37–53
Lorenz MD, Coates JR, Kent M (2011) Stupor and coma. In: Handbook of veterinary neurology. Elsevier Saunders, Missouri, pp 346–383
Platt S, Garosi L (2013) Hydrocephalus. In: Small animal neurological emergencies. Manson Publishing/The Veterinary Press, pp 147–150
Gandini G, Jaggy A, Challande-Kathmann I (2010) Diseases of the cerebrum. In: Jaggy A, Platt SR (eds) Small animal neurology. Schlütersche Verlagsgesellschaft GmbH & Co. KG, Hannover, pp 427–466
Biel M, Kramer M, Forterre F, Jurina K, Lautersack O, Failing K, Schmidt MJ (2013) Outcome of ventriculoperitoneal shunt implantation for treatment of congenital internal hydrocephalus in dogs and cats: 36 cases (2001–2009). J Am Vet Med Assoc 242:948–958
Laubner S, Ondreka N, Failing K, Kramer M, Schmidt M (2015) Magnetic resonance imaging signs of high intraventricular pressure—comparison of findings in dogs with clinically relevant internal hydrocephalus and asymptomatic dogs with ventriculomegaly. BMC Vet Res 11:181
Vullo T, Deo-Narine V, Stallmeyer MJ, Gomez DG, Cahill PT (1996) Quantitation of normal canine hippocampus formation volume: correlation of MRI with gross histology. Magn Reson Imaging 14:657–662
Montie EW, Pussini N, Schneider GE, Battey TW, Dennison S, Barakos J, Gulland F (2009) Neuroanatomy and volumes of brain structures of a live California sea lion (Zalophus californianus) from magnetic resonance images. Anat Rec 292:1523–1547
Kennedy CR, Ayers S, Campbell MJ, Elbourne D, Hope P, Johnson A (2001) Randomized controlled trial of acetazolamide and furosemide in posthemorrhagic ventricular dilation in infancy: follow-up at 1 year. Pediatrics 108:597–607
Itoh T, Nishimura R, Matsunaga S, Kadosawa T, Mochizuki M, Sasaki N (1996) Syringomyelia and hydrocephalus in a dog. J Am Vet Med Assoc 209:934–936
Schwartz TH, Yoon SS, Cutruzzola FW, Goodman RR (1996) Third ventriculostomy: post-operative ventricular size and outcome. Minim Invas Neurosurg 39:122–129
Yamada H, Yokota A, Furuta A, Horie A (1992) Reconstitution of shunted mantle in experimental hydrocephalus. J Neurosurg 76:856–862
Vogh BP (1980) The relation of choroid plexus carbonic anhydrase activity to cerebrospinal fluid formation: study of three inhibitors in cat with extrapolation to man. J Pharmacol Exp Ther 213:321–331
Friedland BR, Maren TH (1994) Pharmacology of the eye—carbonic anhydrase: pharmacology of inhibitors and treatment of glaucoma. Handb Exp Pharmacol 69:279–309
Oppelt WW, Patlak CS, Rall DP (1964) Effect of certain drugs on cerebrospinal fluid production in the dog. Am J Physiol 206:247–250
Holloway LS Jr, Cassin S (1972) Effects of acetazolamide and ouabain on CSF production rate in newborn dogs. Am J Physiol 223:503–506
Nógrádi A, Kelly C, Carter ND (1993) Localization of acetazolamide-resistant carbonic anhydrase III in human and rat choroid plexus by immunocytochemistry and in situ hybridisation. Neurosci Lett 151:162–165