Impact of the Alzheimer's Disease Neuroimaging Initiative, 2004 to 2014

Alzheimer's & Dementia - Tập 11 - Trang 865-884 - 2015
Michael W. Weiner1,2,3,4,5, Dallas P. Veitch1, Paul S. Aisen6, Laurel A. Beckett7, Nigel J. Cairns8,9, Jesse Cedarbaum10, Michael C. Donohue11, Robert C. Green12, Danielle Harvey7, Clifford R. Jack13, William Jagust14, John C. Morris9, Ronald C. Petersen15, Andrew J. Saykin16, Leslie Shaw17, Paul M. Thompson18, Arthur W. Toga19, John Q. Trojanowski20,21,22,23
1Department of Veterans Affairs Medical Center, Center for Imaging of Neurodegenerative Diseases, San Francisco, CA, USA
2Department of Radiology University of California San Francisco, San Francisco, CA, USA
3Department of Medicine, University of California San Francisco, San Francisco, CA, USA
4Department of Psychiatry, University of California San Francisco, San Francisco, CA, USA
5Department of Neurology, University of California-San Francisco, San Francisco, CA, USA
6Department of Neurosciences, University of California–San Diego, La Jolla, CA, USA;
7Division of Biostatistics, Department of Public Health Sciences, University of California Davis, Davis, CA, USA
8Department of Neurology, Knight Alzheimer's Disease Research Center, Washington University School of Medicine, Saint Louis, MO, USA
9Department of Neurology, Washington University School of Medicine, Saint Louis, MO, USA
10Neurology Early Clinical Development, Biogen Idec, Cambridge, MA, USA
11Division of Biostatistics and Bioinformatics, Department of Family Medicine and Public Health, University of California San Diego, San Diego, CA, USA
12Division of Genetics, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA
13Department of Radiology, Mayo Clinic, Rochester, MN, USA
14Helen Wills Neuroscience Institute and the School of Public Health, University of California Berkeley, Berkeley, CA, USA
15Department of Neurology, Mayo Clinic, Rochester, MN, USA
16Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
17Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
18Imaging Genetics Center, Institute for Neuroimaging and Informatics, University of Southern California, Marina Del Rey, CA, USA
19Laboratory of Neuroimaging, Institute of Neuroimaging and Informatics, Keck School of Medicine of University of Southern California Los Angeles, CA, USA
20Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Research, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
21Institute on Aging, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
22Alzheimer's Disease Core Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA
23Udall Parkinson's Research Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

Tóm tắt

AbstractIntroductionThe Alzheimer's Disease Neuroimaging Initiative (ADNI) was established in 2004 to facilitate the development of effective treatments for Alzheimer's disease (AD) by validating biomarkers for AD clinical trials.MethodsWe searched for ADNI publications using established methods.ResultsADNI has (1) developed standardized biomarkers for use in clinical trial subject selection and as surrogate outcome measures; (2) standardized protocols for use across multiple centers; (3) initiated worldwide ADNI; (4) inspired initiatives investigating traumatic brain injury and post‐traumatic stress disorder in military populations, and depression, respectively, as an AD risk factor; (5) acted as a data‐sharing model; (6) generated data used in over 600 publications, leading to the identification of novel AD risk alleles, and an understanding of the relationship between biomarkers and AD progression; and (7) inspired other public‐private partnerships developing biomarkers for Parkinson's disease and multiple sclerosis.DiscussionADNI has made myriad impacts in its first decade. A competitive renewal of the project in 2015 would see the use of newly developed tau imaging ligands, and the continued development of recruitment strategies and outcome measures for clinical trials.

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Alzheimer's & Dementia

Tập 11

865-884

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