Relation of Mammalian Sperm Chromatin Heterogeneity to Fertility

American Association for the Advancement of Science (AAAS) - Tập 210 Số 4474 - Trang 1131-1133 - 1980
Donald P. Evenson1, Zbigniew Darżynkiewicz1, Myron R. Melamed1
1Memorial Sloan-Kettering Cancer Center, New York, 10021

Tóm tắt

Flow cytometry of heated sperm nuclei revealed a significant decrease in resistance to in situ denaturation of spermatozoal DNA in samples from bulls, mice, and humans of low or questionable fertility when compared with others of high fertility. Since thermal denaturation of DNA in situ depends on chromatin structure, it is assumed that changes in sperm chromatin conformation may be related to the diminished fertility. Flow cytometry of heated sperm nuclei may provide a new and independent determinant of male fertility.

Từ khóa


Tài liệu tham khảo

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