Plasticity of NMDA receptor NR2B subunit in memory and chronic pain

Clayton DA, Mesches MH, Alvarez E, Bickford PC, Browning MD: A hippocampal NR2B deficit can mimic age-related changes in long-term potentiation and spatial learning in the Fischer 344 rat. J Neurosci. 2002, 22: 3628-3637. Le Roux N, Amar M, Moreau A, Fossier P: Involvement of NR2A- or NR2B-containing N-methyl-D-aspartate receptors in the potentiation of cortical layer 5 pyramidal neurone inputs depends on the developmental stage. Eur J Neurosci. 2007, 26: 289-301. 10.1111/j.1460-9568.2007.05671.x. Yoshimura Y, Ohmura T, Komatsu Y: Two forms of synaptic plasticity with distinct dependence on age, experience, and NMDA receptor subtype in rat visual cortex. J Neurosci. 2003, 23: 6557-6566. Hoffman DA, Sprengel R, Sakmann B: Molecular dissection of hippocampal theta-burst pairing potentiation. Proc Natl Acad Sci USA. 2002, 99: 7740-7745. 10.1073/pnas.092157999. Zhang XH, Liu F, Chen Q, Zhang CL, Zhuo M, Xiong ZQ, Li BM: Conditioning-strength dependent involvement of NMDA NR2B subtype receptor in the basolateral nucleus of amygdala in acquisition of auditory fear memory. Neuropharmacology. 2008, 55: 238-246. 10.1016/j.neuropharm.2008.05.030. Xu H, Wu LJ, Wang H, Zhang X, Vadakkan KI, Kim SS, Steenland HW, Zhuo M: Presynaptic and postsynaptic amplifications of neuropathic pain in the anterior cingulate cortex. J Neurosci. 2008, 28: 7445-7453. 10.1523/JNEUROSCI.1812-08.2008. Bliss TV, Collingridge GL: A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 1993, 361: 31-39. 10.1038/361031a0. Malenka RC, Nicoll RA: Long-term potentiation–a decade of progress?. Science. 1999, 285: 1870-1874. 10.1126/science.285.5435.1870. Kandel ER: The molecular biology of memory storage: a dialogue between genes and synapses. Science. 2001, 294: 1030-1038. 10.1126/science.1067020. Malinow R, Malenka RC: AMPA receptor trafficking and synaptic plasticity. Annu Rev Neurosci. 2002, 25: 103-126. 10.1146/annurev.neuro.25.112701.142758. Rodrigues SM, Schafe GE, LeDoux JE: Molecular mechanisms underlying emotional learning and memory in the lateral amygdala. Neuron. 2004, 44: 75-91. 10.1016/j.neuron.2004.09.014. Wei F, Vadakkan KI, Toyoda H, Wu LJ, Zhao MG, Xu H, Shum FW, Jia YH, Zhuo M: Calcium calmodulin-stimulated adenylyl cyclases contribute to activation of extracellular signal-regulated kinase in spinal dorsal horn neurons in adult rats and mice. J Neurosci. 2006, 26: 851-861. 10.1523/JNEUROSCI.3292-05.2006. Ikeda H, Heinke B, Ruscheweyh R, Sandkuhler J: Synaptic plasticity in spinal lamina I projection neurons that mediate hyperalgesia. Science. 2003, 299: 1237-1240. 10.1126/science.1080659. Ikeda H, Stark J, Fischer H, Wagner M, Drdla R, Jager T, Sandkuhler J: Synaptic amplifier of inflammatory pain in the spinal dorsal horn. Science. 2006, 312: 1659-1662. 10.1126/science.1127233. Tsvetkov E, Shin RM, Bolshakov VY: Glutamate uptake determines pathway specificity of long-term potentiation in the neural circuitry of fear conditioning. Neuron. 2004, 41: 139-151. 10.1016/S0896-6273(03)00800-6. Zhao MG, Toyoda H, Lee YS, Wu LJ, Ko SW, Zhang XH, Jia Y, Shum F, Xu H, Li BM, Kaang BK, Zhuo M: Roles of NMDA NR2B subtype receptor in prefrontal long-term potentiation and contextual fear memory. Neuron. 2005, 47: 859-872. 10.1016/j.neuron.2005.08.014. Wu LJ, Toyoda H, Zhao MG, Lee YS, Tang J, Ko SW, Jia YH, Shum FW, Zerbinatti CV, Bu G, Wei F, Xu TL, Muglia LJ, Chen ZF, Auberson YP, Kaang BK, Zhuo M: Upregulation of forebrain NMDA NR2B receptors contributes to behavioral sensitization after inflammation. J Neurosci. 2005, 25: 11107-11116. 10.1523/JNEUROSCI.1678-05.2005. Zhuo M: Cortical excitation and chronic pain. Trends Neurosci. 2008, 31: 199-207. 10.1016/j.tins.2008.01.003. Sigurdsson T, Doyere V, Cain CK, LeDoux JE: Long-term potentiation in the amygdala: a cellular mechanism of fear learning and memory. Neuropharmacology. 2007, 52: 215-227. 10.1016/j.neuropharm.2006.06.022. Grover LM, Teyler TJ: Two components of long-term potentiation induced by different patterns of afferent activation. Nature. 1990, 347: 477-479. 10.1038/347477a0. Huang YY, Malenka RC: Examination of TEA-induced synaptic enhancement in area CA1 of the hippocampus: the role of voltage-dependent Ca2+ channels in the induction of LTP. J Neurosci. 1993, 13: 568-576. Zhuo M, Laitinen JT, Li XC, Hawkins RD: On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippocampus. Learn Mem. 1999, 6: 63-76. Ko S, Zhao MG, Toyoda H, Qiu CS, Zhuo M: Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 (GluR5)- or GluR6-deficient mice. J Neurosci. 2005, 25: 977-984. 10.1523/JNEUROSCI.4059-04.2005. Dingledine R, Borges K, Bowie D, Traynelis SF: The glutamate receptor ion channels. Pharmacol Rev. 1999, 51: 7-61. Cull-Candy S, Brickley S, Farrant M: NMDA receptor subunits: diversity, development and disease. Curr Opin Neurobiol. 2001, 11: 327-335. 10.1016/S0959-4388(00)00215-4. Vicini S, Wang JF, Li JH, Zhu WJ, Wang YH, Luo JH, Wolfe BB, Grayson DR: Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors. J Neurophysiol. 1998, 79: 555-566. Erreger K, Geballe MT, Dravid SM, Snyder JP, Wyllie DJ, Traynelis SF: Mechanism of partial agonism at NMDA receptors for a conformationally restricted glutamate analog. J Neurosci. 2005, 25: 7858-7866. 10.1523/JNEUROSCI.1613-05.2005. Miwa H, Fukaya M, Watabe AM, Watanabe M, Manabe T: Functional contributions of synaptically localized NR2B subunits of the NMDA receptor to synaptic transmission and long-term potentiation in the adult mouse CNS. J Physiol. 2008, 586: 2539-2550. 10.1113/jphysiol.2007.147652. Liu L, Wong TP, Pozza MF, Lingenhoehl K, Wang Y, Sheng M, Auberson YP, Wang YT: Role of NMDA receptor subtypes in governing the direction of hippocampal synaptic plasticity. Science. 2004, 304: 1021-1024. 10.1126/science.1096615. Tang YP, Shimizu E, Dube GR, Rampon C, Kerchner GA, Zhuo M, Liu G, Tsien JZ: Genetic enhancement of learning and memory in mice. Nature. 1999, 401: 63-69. 10.1038/43432. Bauer EP, Schafe GE, LeDoux JE: NMDA receptors and L-type voltage-gated calcium channels contribute to long-term potentiation and different components of fear memory formation in the lateral amygdala. J Neurosci. 2002, 22: 5239-5249. Massey PV, Johnson BE, Moult PR, Auberson YP, Brown MW, Molnar E, Collingridge GL, Bashir ZI: Differential roles of NR2A and NR2B-containing NMDA receptors in cortical long-term potentiation and long-term depression. J Neurosci. 2004, 24: 7821-7828. 10.1523/JNEUROSCI.1697-04.2004. Berberich S, Jensen V, Hvalby O, Seeburg PH, Kohr G: The role of NMDAR subtypes and charge transfer during hippocampal LTP induction. Neuropharmacology. 2007, 52: 77-86. 10.1016/j.neuropharm.2006.07.016. Guscott MR, Clarke HF, Murray F, Grimwood S, Bristow LJ, Hutson PH: The effect of (+/-)-CP-101,606, an NMDA receptor NR2B subunit selective antagonist, in the Morris watermaze. Eur J Pharmacol. 2003, 476: 193-199. 10.1016/S0014-2999(03)02182-4. Rodrigues SM, Schafe GE, LeDoux JE: Intra-amygdala blockade of the NR2B subunit of the NMDA receptor disrupts the acquisition but not the expression of fear conditioning. J Neurosci. 2001, 21: 6889-6896. Dalton GL, Wang YT, Floresco SB, Phillips AG: Disruption of AMPA receptor endocytosis impairs the extinction, but not acquisition of learned fear. Neuropsychopharmacology. 2008, 33: 2416-2426. 10.1038/sj.npp.1301642. Zinebi F, Xie J, Liu J, Russell RT, Gallagher JP, McKernan MG, Shinnick-Gallagher P: NMDA currents and receptor protein are downregulated in the amygdala during maintenance of fear memory. J Neurosci. 2003, 23: 10283-10291. Philpot BD, Sekhar AK, Shouval HZ, Bear MF: Visual experience and deprivation bidirectionally modify the composition and function of NMDA receptors in visual cortex. Neuron. 2001, 29: 157-169. 10.1016/S0896-6273(01)00187-8. Sawtell NB, Frenkel MY, Philpot BD, Nakazawa K, Tonegawa S, Bear MF: NMDA receptor-dependent ocular dominance plasticity in adult visual cortex. Neuron. 2003, 38: 977-985. 10.1016/S0896-6273(03)00323-4. Tongiorgi E, Ferrero F, Cattaneo A, Domenici L: Dark-rearing decreases NR2A N-methyl-D-aspartate receptor subunit in all visual cortical layers. Neuroscience. 2003, 119: 1013-1022. 10.1016/S0306-4522(03)00196-9. Walker DL, Davis M: Amygdala infusions of an NR2B-selective or an NR2A-preferring NMDA receptor antagonist differentially influence fear conditioning and expression in the fear-potentiated startle test. Learn Mem. 2008, 15: 67-74. 10.1101/lm.798908. Wei F, Qiu CS, Kim SJ, Muglia L, Maas JW, Pineda VV, Xu HM, Chen ZF, Storm DR, Muglia LJ, Zhuo M: Genetic elimination of behavioral sensitization in mice lacking calmodulin-stimulated adenylyl cyclases. Neuron. 2002, 36: 713-726. 10.1016/S0896-6273(02)01019-X. Wei F, Wang GD, Kerchner GA, Kim SJ, Xu HM, Chen ZF, Zhuo M: Genetic enhancement of inflammatory pain by forebrain NR2B overexpression. Nat Neurosci. 2001, 4: 164-169. 10.1038/83993. Setou M, Nakagawa T, Seog DH, Hirokawa N: Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science. 2000, 288 (5472): 1796-802. 10.1126/science.288.5472.1796. Wong RW, Setou M, Teng J, Takei Y, Hirokawa N: Overexpression of motor protein KIF17 enhances spatial and working memory in transgenic mice. Proc Natl Acad Sci USA. 2002, 99: 14500-14505. 10.1073/pnas.222371099. Guillaud L, Setou M, Hirokawa N: KIF17 dynamics and regulation of NR2B trafficking in hippocampal neurons. J Neurosci. 2003, 23: 131-140. Liauw J, Wu LJ, Zhuo M: Calcium-stimulated adenylyl cyclases required for long-term potentiation in the anterior cingulate cortex. J Neurophysiol. 2005, 94: 878-882. 10.1152/jn.01205.2004. Toyoda H, Wu LJ, Zhao MG, Xu H, Zhuo M: Time-dependent postsynaptic AMPA GluR1 receptor recruitment in the cingulate synaptic potentiation. Dev Neurobiol. 2007, 67: 498-509. 10.1002/dneu.20380.