Local Inhibition of MicroRNA-24 Improves Reparative Angiogenesis and Left Ventricle Remodeling and Function in Mice With Myocardial Infarction

Rosamond, 2007, Heart disease and stroke statistics–2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee, Circulation, 115, e69, 10.1161/CIRCULATIONAHA.106.179918 Olivetti, 1996, Acute myocardial infarction in humans is associated with activation of programmed myocyte cell death in the surviving portion of the heart, J Mol Cell Cardiol, 28, 2005, 10.1006/jmcc.1996.0193 Anversa, 1998, Apoptosis and myocardial infarction, Basic Res Cardiol, 93, 8, 10.1007/s003950050195 Sutton, 2000, Left ventricular remodeling after myocardial infarction: pathophysiology and therapy, Circulation, 101, 2981, 10.1161/01.CIR.101.25.2981 Krichavsky, 2011, Prevention and recovery of hibernating myocardium by microvascular repair, Circulation, 124, 998, 10.1161/CIRCULATIONAHA.111.047746 Henry, 2003, The VIVA trial: Vascular endothelial growth factor in Ischemia for Vascular Angiogenesis, Circulation, 107, 1359, 10.1161/01.CIR.0000061911.47710.8A Stewart, 2009, VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: results of the NORTHERN trial, Mol Ther, 17, 1109, 10.1038/mt.2009.70 Caporali, 2011, MicroRNA regulation in angiogenesis, Vascul Pharmacol, 55, 79, 10.1016/j.vph.2011.06.006 Bartel, 2009, MicroRNAs: target recognition and regulatory functions, Cell, 136, 215, 10.1016/j.cell.2009.01.002 Friedman, 2009, Most mammalian mRNAs are conserved targets of microRNAs, Genome Res, 19, 92, 10.1101/gr.082701.108 Bonauer, 2009, MicroRNA-92a controls angiogenesis and functional recovery of ischemic tissues in mice, Science, 324, 1710, 10.1126/science.1174381 Fiedler, 2011, MicroRNA-24 regulates vascularity after myocardial infarction, Circulation, 124, 720, 10.1161/CIRCULATIONAHA.111.039008 Wang, 2010, MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury, Circulation, 122, 1308, 10.1161/CIRCULATIONAHA.110.964684 Qian, 2011, miR-24 inhibits apoptosis and represses Bim in mouse cardiomyocytes, J Exp Med, 208, 549, 10.1084/jem.20101547 Wang, 2011, miR-499 regulates mitochondrial dynamics by targeting calcineurin and dynamin-related protein-1, Nat Med, 17, 71, 10.1038/nm.2282 Matkovich, 2010, MicroRNA-133a protects against myocardial fibrosis and modulates electrical repolarization without affecting hypertrophy in pressure-overloaded adult hearts, Circ Res, 106, 166, 10.1161/CIRCRESAHA.109.202176 Hu, 2010, MicroRNA-210 as a novel therapy for treatment of ischemic heart disease, Circulation, 122, S124 van Rooij, 2008, Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis, Proc Natl Acad Sci USA, 105, 13027, 10.1073/pnas.0805038105 Thum, 2008, MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts, Nature, 456, 980, 10.1038/nature07511 Hu, 2011, Novel microRNA prosurvival cocktail for improving engraftment and function of cardiac progenitor cell transplantation, Circulation, 124, S27 Wang, 2012, MicroRNA-24 regulates cardiac fibrosis after myocardial infarction, J Cell Mol Med, 16, 2150, 10.1111/j.1582-4934.2012.01523.x Caporali, 2011, Deregulation of microRNA-503 contributes to diabetes mellitus-induced impairment of endothelial function and reparative angiogenesis after limb ischemia, Circulation, 123, 282, 10.1161/CIRCULATIONAHA.110.952325 Kiriakidou, 2004, A combined computational-experimental approach predicts human microRNA targets, Genes Dev, 18, 1165, 10.1101/gad.1184704 Gill, 2002, Losing heart: the role of apoptosis in heart disease–a novel therapeutic target?, FASEB J, 16, 135, 10.1096/fj.01-0629com Meloni, 2010, Nerve growth factor promotes cardiac repair following myocardial infarction, Circ Res, 106, 1275, 10.1161/CIRCRESAHA.109.210088 Park, 2009, Apoptosis predominates in nonmyocytes in heart failure, Am J Physiol Heart Circ Physiol, 297, H785, 10.1152/ajpheart.00310.2009 Lutgens, 1999, Chronic myocardial infarction in the mouse: cardiac structural and functional changes, Cardiovasc Res, 41, 586, 10.1016/S0008-6363(98)00216-8 Zhao, 2007, Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2, Cell, 129, 303, 10.1016/j.cell.2007.03.030 Zhao, 2005, Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis, Nature, 436, 214, 10.1038/nature03817 Morton, 2008, microRNA-138 modulates cardiac patterning during embryonic development, Proc Natl Acad Sci USA, 105, 17830, 10.1073/pnas.0804673105 Cordes, 2009, MicroRNA regulation of cardiovascular development, Circ Res, 104, 724, 10.1161/CIRCRESAHA.108.192872 Carè, 2007, MicroRNA-133 controls cardiac hypertrophy, Nat Med, 13, 613, 10.1038/nm1582 Eulalio, 2012, Functional screening identifies miRNAs inducing cardiac regeneration, Nature, 492, 376, 10.1038/nature11739 Ebert, 2007, MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells, Nat Methods, 4, 721, 10.1038/nmeth1079 van Rooij, 2012, Developing microRNA therapeutics, Circ Res, 110, 496, 10.1161/CIRCRESAHA.111.247916 Larsson, 2009, Discovery of microvascular miRNAs using public gene expression data: miR-145 is expressed in pericytes and is a regulator of Fli1, Genome Med, 1, 108, 10.1186/gm108 Murohara, 1998, Nitric oxide synthase modulates angiogenesis in response to tissue ischemia, J Clin Invest, 101, 2567, 10.1172/JCI1560 Schrage, 2008, Murine CD146 is widely expressed on endothelial cells and is recognized by the monoclonal antibody ME-9F1, Histochem Cell Biol, 129, 441, 10.1007/s00418-008-0379-x Claycomb, 1998, HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte, Proc Natl Acad Sci USA, 95, 2979, 10.1073/pnas.95.6.2979 Bonci, 2008, The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities, Nat Med, 14, 1271, 10.1038/nm.1880 Sala-Newby, 2003, Metabolic and functional consequences of cytosolic 5’-nucleotidase-IA overexpression in neonatal rat cardiomyocytes, Am J Physiol Heart Circ Physiol, 285, H991, 10.1152/ajpheart.00053.2003