Identifying biological themes within lists of genes with EASE

Genome Biology - Tập 4 - Trang 1-18 - 2003
Douglas A Hosack1, Glynn Dennis1, Brad T Sherman1, H Clifford Lane2, Richard A Lempicki1
1Laboratory of Immunopathogenesis and Bioinformatics, Frederick, USA
2Clinical and Molecular Retrovirology Section, Bldg 10, Room 11S-231, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, USA

Tóm tắt

EASE is a customizable software application for rapid biological interpretation of gene lists that result from the analysis of microarray, proteomics, SAGE, and other high-throughput genomic data. The biological themes returned by EASE recapitulate manually determined themes in previously published gene lists and are robust to varying methods of normalization, intensity calculation and statistical selection of genes. EASE is a powerful tool for rapidly converting the results of functional genomics studies from "genes to themes."

Tài liệu tham khảo

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