Formulation and Characterization of Drug Loaded Nonionic Surfactant Vesicles (Niosomes) for Oral Bioavailability Enhancement

Hindawi Limited - Tập 2014 - Trang 1-8 - 2014
Sunil Kamboj1, Vipin Saini1, Suman Bala1
1M.M. College of Pharmacy, Maharishi Markandeshwar University, Mullana, Ambala 133207, Haryana, India.

Tóm tắt

Nonionic surfactant vesicles (niosomes) were formulated with an aim of enhancing the oral bioavailability of tenofovir disoproxil fumarate (TDF), an anti-HIV drug. Niosomes were formulated by conventional thin film hydration technique with different molar ratios of surfactant, cholesterol, and dicetyl phosphate. The formulated niosomes were found spherical in shape, ranging from 2.95 μm to 10.91 μm in size. Vesicles with 1 : 1 : 0.1 ratios of surfactant : cholesterol : dicetyl phosphate with each grade of span were found to have higher entrapment efficiencies, which were further selected forin vitroandin vivostudies. Vesicles formulated with sorbitan monostearate were found to have maximum drug release (99.091%) at the end of 24 hours and followed zero order release kinetics. The results ofin vivostudy revealed that the niosomes significantly enhanced the oral bioavailability of TDF in rats after a dose of 95 mg/kg. The average relative bioavailability of niosomes in relation to plane drug solution was found to be 2.58, indicating more than twofold increase in oral bioavailability of TDF. Significant increase in mean residential time (MRT) was also found, reflecting release retarding efficacy of the vesicles. In conclusion, niosomes could be a promising delivery for TDF with improved oral bioavailability and prolonged release profiles.

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Tài liệu tham khảo

2009, Pakistan Journal of Pharmaceutical Sciences, 22, 27

10.1128/AAC.49.2.680-684.2005

10.1157/13126265

10.1517/17425247.2.3.419

2006, Indian Journal of Pharmaceutical Sciences, 68, 141, 10.4103/0250-474X.25707

10.1080/02652040802055411

2011, Acta Pharmaceutica Sinica B, 1, 208, 10.1016/j.apsb.2011.09.002

2008, International Journal of Pharmaceutical Sciences and Nanotechnology, 1, 1, 10.37285/ijpsn.2008.1.1.1

10.1208/s12249-012-9805-4

10.1208/s12249-010-9480-2

2012, International Journal of Biological and Pharmaceutical Research, 3, 354

2007, AAPS PharmSciTech, 8, E1, 10.1208/pt0804080

2010, Acta Poloniae Pharmaceutica, 67, 217

10.1208/s12249-009-9325-z

2011, Indian Journal of Experimental Biology, 49, 438

10.1016/S0927-7765(03)00080-8

10.4103/0973-8398.76752

10.1016/j.ijpharm.2009.04.020

10.1248/bpb.32.1453

1985, Journal of Pharmacy and Pharmacology, 37, 237, 10.1111/j.2042-7158.1985.tb05051.x

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Hindawi Limited

Tập 2014

1-8

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