A diffusion tensor imaging study of structural dysconnectivity in never-medicated, first-episode schizophrenia

Psychological Medicine - Tập 38 Số 6 - Trang 877-885 - 2008
Vincent C. K. Cheung1, CW Cheung1, Gráinne McAlonan1,2, Yi Deng1, J. G. Wong1, Lawrance Yip3, KS Tai3, Pek‐Lan Khong3,2, Pak C. Sham1,2, Siew E. Chua1,2
1Department of Psychiatry, The University of Hong Kong, Pokfulam, S.A.R.China
2State Key Laboratory for Brain and Cognitive Sciences, The University of Hong Kong, Pokfulam, S.A.R.China
3Department of Radiology, Queen Mary Hospital, Pokfulam, S.A.R.China

Tóm tắt

BackgroundDiffusion tensor imaging (DTI) can be used to investigate cerebral structural connectivity in never-medicated individuals with first-episode schizophrenia.MethodSubjects with first-episode schizophrenia according to DSM-IV-R who had never been exposed to antipsychotic medication (n=25) and healthy controls (n=26) were recruited. Groups were matched for age, gender, best parental socio-economic status and ethnicity. All subjects underwent DTI and structural magnetic resonance imaging (MRI) scans. Voxel-based analysis was performed to investigate brain regions where fractional anisotropy (FA) values differed significantly between groups. A confirmatory region-of-interest (ROI) analysis of FA scores was performed in which regions were placed blind to group membership.ResultsIn patients, FA values significantly lower than those in healthy controls were located in the left fronto-occipital fasciculus, left inferior longitudinal fasciculus, white matter adjacent to right precuneus, splenium of corpus callosum, right posterior limb of internal capsule, white matter adjacent to right substantia nigra, and left cerebral peduncle. ROI analysis of the corpus callosum confirmed that the patient group had significantly lower mean FA values than the controls in the splenium but not in the genu. The intra-class correlation coefficient (ICC) for independent ROI measurements was 0.90 (genu) and 0.90 (splenium). There were no regions where FA values were significantly higher in the patients than in the healthy controls.ConclusionsWidespread structural dysconnectivity, including the subcortical region, is already present in neuroleptic-naive patients in their first episode of illness.

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Psychological Medicine

Tập 38 Số 6

877-885

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